Twist1 Inactivation in Dmp1-Expressing Cells Increases Bone Mass but Does Not Affect the Anabolic Response to Sclerostin Neutralization

Wnt signaling plays a major role in bone metabolism. Advances in our understanding of secreted regulators of Wnt have yielded several therapeutic targets to stimulate osteoanabolism—the most promising of which is the Wnt inhibitor sclerostin. Sclerostin antibody recently gained approval for clinical...

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Detalles Bibliográficos
Autores principales: Lewis, Karl J., Choi, Roy B-J, Pemberton, Emily Z., Bullock, Whitney A., Firulli, Anthony B., Robling, Alexander G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769567/
https://www.ncbi.nlm.nih.gov/pubmed/31505764
http://dx.doi.org/10.3390/ijms20184427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769567/
https://www.ncbi.nlm.nih.gov/pubmed/31505764
http://dx.doi.org/10.3390/ijms20184427

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