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(18)F-Facbc in Prostate Cancer: A Systematic Review and Meta-Analysis

Trans-1-amino-3-(18)F-fluorocyclobutanecarboxylic-acid (anti-[(18)F]-FACBC) has been approved for the detection of prostate cancer (PCa) in patients with elevated prostate-specific-antigen following prior treatment. This review and meta-analysis aimed to investigate the diagnostic performance of (18...

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Autores principales: Laudicella, Riccardo, Albano, Domenico, Alongi, Pierpaolo, Argiroffi, Giovanni, Bauckneht, Matteo, Baldari, Sergio, Bertagna, Francesco, Boero, Michele, De Vincentis, Giuseppe, Del Sole, Angelo, Rubini, Giuseppe, Fantechi, Lorenzo, Frantellizzi, Viviana, Ganduscio, Gloria, Guglielmo, Priscilla, Nappi, Anna Giulia, Evangelista, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769578/
https://www.ncbi.nlm.nih.gov/pubmed/31514479
http://dx.doi.org/10.3390/cancers11091348
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author Laudicella, Riccardo
Albano, Domenico
Alongi, Pierpaolo
Argiroffi, Giovanni
Bauckneht, Matteo
Baldari, Sergio
Bertagna, Francesco
Boero, Michele
De Vincentis, Giuseppe
Del Sole, Angelo
Rubini, Giuseppe
Fantechi, Lorenzo
Frantellizzi, Viviana
Ganduscio, Gloria
Guglielmo, Priscilla
Nappi, Anna Giulia
Evangelista, Laura
author_facet Laudicella, Riccardo
Albano, Domenico
Alongi, Pierpaolo
Argiroffi, Giovanni
Bauckneht, Matteo
Baldari, Sergio
Bertagna, Francesco
Boero, Michele
De Vincentis, Giuseppe
Del Sole, Angelo
Rubini, Giuseppe
Fantechi, Lorenzo
Frantellizzi, Viviana
Ganduscio, Gloria
Guglielmo, Priscilla
Nappi, Anna Giulia
Evangelista, Laura
author_sort Laudicella, Riccardo
collection PubMed
description Trans-1-amino-3-(18)F-fluorocyclobutanecarboxylic-acid (anti-[(18)F]-FACBC) has been approved for the detection of prostate cancer (PCa) in patients with elevated prostate-specific-antigen following prior treatment. This review and meta-analysis aimed to investigate the diagnostic performance of (18)F-FACBC positron emission tomography/computed-tomography (PET/CT) in the detection of primary/recurrent PCa. A bibliographic search was performed including several databases, using the following terms: “FACBC”/“fluciclovine” AND “prostate cancer”/“prostate” AND “PET”/“Positron Emission Tomography”. Fifteen and 9 studies were included in the systematic reviews and meta-analysis, respectively. At patient-based analysis, the pooled sensitivity and specificity of (18)F-FACBC-PET/CT for the assessment of PCa were 86.3% and 75.9%, respectively. The pooled diagnostic odds-ratio value was 16.453, with heterogeneity of 30%. At the regional-based-analysis, the pooled sensitivity of (18)F-FACBC-PET/CT for the evaluation of primary/recurrent disease in the prostatic bed was higher than in the extra-prostatic regions (90.4% vs. 76.5%, respectively); conversely, the pooled specificity was higher for the evaluation of extra-prostatic region than the prostatic bed (89% vs. 45%, respectively). (18)F-FACBC-PET/CT seems to be promising in recurrent PCa, particularly for the evaluation of the prostatic bed. Additional studies to evaluate its utility in clinical routine are mandatory.
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spelling pubmed-67695782019-10-30 (18)F-Facbc in Prostate Cancer: A Systematic Review and Meta-Analysis Laudicella, Riccardo Albano, Domenico Alongi, Pierpaolo Argiroffi, Giovanni Bauckneht, Matteo Baldari, Sergio Bertagna, Francesco Boero, Michele De Vincentis, Giuseppe Del Sole, Angelo Rubini, Giuseppe Fantechi, Lorenzo Frantellizzi, Viviana Ganduscio, Gloria Guglielmo, Priscilla Nappi, Anna Giulia Evangelista, Laura Cancers (Basel) Review Trans-1-amino-3-(18)F-fluorocyclobutanecarboxylic-acid (anti-[(18)F]-FACBC) has been approved for the detection of prostate cancer (PCa) in patients with elevated prostate-specific-antigen following prior treatment. This review and meta-analysis aimed to investigate the diagnostic performance of (18)F-FACBC positron emission tomography/computed-tomography (PET/CT) in the detection of primary/recurrent PCa. A bibliographic search was performed including several databases, using the following terms: “FACBC”/“fluciclovine” AND “prostate cancer”/“prostate” AND “PET”/“Positron Emission Tomography”. Fifteen and 9 studies were included in the systematic reviews and meta-analysis, respectively. At patient-based analysis, the pooled sensitivity and specificity of (18)F-FACBC-PET/CT for the assessment of PCa were 86.3% and 75.9%, respectively. The pooled diagnostic odds-ratio value was 16.453, with heterogeneity of 30%. At the regional-based-analysis, the pooled sensitivity of (18)F-FACBC-PET/CT for the evaluation of primary/recurrent disease in the prostatic bed was higher than in the extra-prostatic regions (90.4% vs. 76.5%, respectively); conversely, the pooled specificity was higher for the evaluation of extra-prostatic region than the prostatic bed (89% vs. 45%, respectively). (18)F-FACBC-PET/CT seems to be promising in recurrent PCa, particularly for the evaluation of the prostatic bed. Additional studies to evaluate its utility in clinical routine are mandatory. MDPI 2019-09-11 /pmc/articles/PMC6769578/ /pubmed/31514479 http://dx.doi.org/10.3390/cancers11091348 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Laudicella, Riccardo
Albano, Domenico
Alongi, Pierpaolo
Argiroffi, Giovanni
Bauckneht, Matteo
Baldari, Sergio
Bertagna, Francesco
Boero, Michele
De Vincentis, Giuseppe
Del Sole, Angelo
Rubini, Giuseppe
Fantechi, Lorenzo
Frantellizzi, Viviana
Ganduscio, Gloria
Guglielmo, Priscilla
Nappi, Anna Giulia
Evangelista, Laura
(18)F-Facbc in Prostate Cancer: A Systematic Review and Meta-Analysis
title (18)F-Facbc in Prostate Cancer: A Systematic Review and Meta-Analysis
title_full (18)F-Facbc in Prostate Cancer: A Systematic Review and Meta-Analysis
title_fullStr (18)F-Facbc in Prostate Cancer: A Systematic Review and Meta-Analysis
title_full_unstemmed (18)F-Facbc in Prostate Cancer: A Systematic Review and Meta-Analysis
title_short (18)F-Facbc in Prostate Cancer: A Systematic Review and Meta-Analysis
title_sort (18)f-facbc in prostate cancer: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769578/
https://www.ncbi.nlm.nih.gov/pubmed/31514479
http://dx.doi.org/10.3390/cancers11091348
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