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Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins

(1) Background: Zinc is an essential micronutrient and zinc deficiency is associated with immune dysfunction. The neonatal immune system is immature, and therefore an optimal neonatal zinc status may be important. The aim of this study was to investigate the possible association between neonatal who...

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Autores principales: Kyvsgaard, Julie Nyholm, Ellervik, Christina, Lindkvist, Emilie Bundgaard, Pipper, Christian Bressen, Pociot, Flemming, Svensson, Jannet, Thorsen, Steffen Ullitz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769600/
https://www.ncbi.nlm.nih.gov/pubmed/31443415
http://dx.doi.org/10.3390/nu11091980
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author Kyvsgaard, Julie Nyholm
Ellervik, Christina
Lindkvist, Emilie Bundgaard
Pipper, Christian Bressen
Pociot, Flemming
Svensson, Jannet
Thorsen, Steffen Ullitz
author_facet Kyvsgaard, Julie Nyholm
Ellervik, Christina
Lindkvist, Emilie Bundgaard
Pipper, Christian Bressen
Pociot, Flemming
Svensson, Jannet
Thorsen, Steffen Ullitz
author_sort Kyvsgaard, Julie Nyholm
collection PubMed
description (1) Background: Zinc is an essential micronutrient and zinc deficiency is associated with immune dysfunction. The neonatal immune system is immature, and therefore an optimal neonatal zinc status may be important. The aim of this study was to investigate the possible association between neonatal whole blood (WB)-Zinc content and several immune markers. (2) Methods: In total, 398 healthy newborns (199 who later developed type 1 diabetes and 199 controls) from the Danish Newborn Screening Biobank had neonatal dried blood spots (NDBS) analyzed for WB-Zinc content and (i) cytokines: Interleukin (IL)-1β, IL-4, IL-6, IL-8, IL-10, IL-12 (p70), interferon gamma, tumor necrosis factor alpha, and transforming growth factor beta; (ii) adipokines: leptin and adiponectin; (iii) other immune response proteins: C-reactive protein (CRP), and mannose-binding lectin (MBL), and soluble triggering receptors expressed on myeloid cells1 (sTREM-1). WB-Zinc content was determined using laser ablation inductively coupled plasma mass spectrometry. For each analyte, the relative change in mean level was modelled by a robust log-normal model regression. (3) Results: No association was found between WB-Zinc content and all the immune response markers in either the unadjusted or adjusted models overall or when stratifying by case status. (4) Conclusions: In healthy Danish neonates, WB-Zinc content was not associated with cytokines, adipokines, CRP, MBL or sTREM, which does not indicate a strong immunological function of neonatal zinc status.
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spelling pubmed-67696002019-10-30 Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins Kyvsgaard, Julie Nyholm Ellervik, Christina Lindkvist, Emilie Bundgaard Pipper, Christian Bressen Pociot, Flemming Svensson, Jannet Thorsen, Steffen Ullitz Nutrients Article (1) Background: Zinc is an essential micronutrient and zinc deficiency is associated with immune dysfunction. The neonatal immune system is immature, and therefore an optimal neonatal zinc status may be important. The aim of this study was to investigate the possible association between neonatal whole blood (WB)-Zinc content and several immune markers. (2) Methods: In total, 398 healthy newborns (199 who later developed type 1 diabetes and 199 controls) from the Danish Newborn Screening Biobank had neonatal dried blood spots (NDBS) analyzed for WB-Zinc content and (i) cytokines: Interleukin (IL)-1β, IL-4, IL-6, IL-8, IL-10, IL-12 (p70), interferon gamma, tumor necrosis factor alpha, and transforming growth factor beta; (ii) adipokines: leptin and adiponectin; (iii) other immune response proteins: C-reactive protein (CRP), and mannose-binding lectin (MBL), and soluble triggering receptors expressed on myeloid cells1 (sTREM-1). WB-Zinc content was determined using laser ablation inductively coupled plasma mass spectrometry. For each analyte, the relative change in mean level was modelled by a robust log-normal model regression. (3) Results: No association was found between WB-Zinc content and all the immune response markers in either the unadjusted or adjusted models overall or when stratifying by case status. (4) Conclusions: In healthy Danish neonates, WB-Zinc content was not associated with cytokines, adipokines, CRP, MBL or sTREM, which does not indicate a strong immunological function of neonatal zinc status. MDPI 2019-08-22 /pmc/articles/PMC6769600/ /pubmed/31443415 http://dx.doi.org/10.3390/nu11091980 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kyvsgaard, Julie Nyholm
Ellervik, Christina
Lindkvist, Emilie Bundgaard
Pipper, Christian Bressen
Pociot, Flemming
Svensson, Jannet
Thorsen, Steffen Ullitz
Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins
title Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins
title_full Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins
title_fullStr Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins
title_full_unstemmed Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins
title_short Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins
title_sort perinatal whole blood zinc status and cytokines, adipokines, and other immune response proteins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769600/
https://www.ncbi.nlm.nih.gov/pubmed/31443415
http://dx.doi.org/10.3390/nu11091980
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