Cargando…
Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins
(1) Background: Zinc is an essential micronutrient and zinc deficiency is associated with immune dysfunction. The neonatal immune system is immature, and therefore an optimal neonatal zinc status may be important. The aim of this study was to investigate the possible association between neonatal who...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769600/ https://www.ncbi.nlm.nih.gov/pubmed/31443415 http://dx.doi.org/10.3390/nu11091980 |
_version_ | 1783455275419697152 |
---|---|
author | Kyvsgaard, Julie Nyholm Ellervik, Christina Lindkvist, Emilie Bundgaard Pipper, Christian Bressen Pociot, Flemming Svensson, Jannet Thorsen, Steffen Ullitz |
author_facet | Kyvsgaard, Julie Nyholm Ellervik, Christina Lindkvist, Emilie Bundgaard Pipper, Christian Bressen Pociot, Flemming Svensson, Jannet Thorsen, Steffen Ullitz |
author_sort | Kyvsgaard, Julie Nyholm |
collection | PubMed |
description | (1) Background: Zinc is an essential micronutrient and zinc deficiency is associated with immune dysfunction. The neonatal immune system is immature, and therefore an optimal neonatal zinc status may be important. The aim of this study was to investigate the possible association between neonatal whole blood (WB)-Zinc content and several immune markers. (2) Methods: In total, 398 healthy newborns (199 who later developed type 1 diabetes and 199 controls) from the Danish Newborn Screening Biobank had neonatal dried blood spots (NDBS) analyzed for WB-Zinc content and (i) cytokines: Interleukin (IL)-1β, IL-4, IL-6, IL-8, IL-10, IL-12 (p70), interferon gamma, tumor necrosis factor alpha, and transforming growth factor beta; (ii) adipokines: leptin and adiponectin; (iii) other immune response proteins: C-reactive protein (CRP), and mannose-binding lectin (MBL), and soluble triggering receptors expressed on myeloid cells1 (sTREM-1). WB-Zinc content was determined using laser ablation inductively coupled plasma mass spectrometry. For each analyte, the relative change in mean level was modelled by a robust log-normal model regression. (3) Results: No association was found between WB-Zinc content and all the immune response markers in either the unadjusted or adjusted models overall or when stratifying by case status. (4) Conclusions: In healthy Danish neonates, WB-Zinc content was not associated with cytokines, adipokines, CRP, MBL or sTREM, which does not indicate a strong immunological function of neonatal zinc status. |
format | Online Article Text |
id | pubmed-6769600 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67696002019-10-30 Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins Kyvsgaard, Julie Nyholm Ellervik, Christina Lindkvist, Emilie Bundgaard Pipper, Christian Bressen Pociot, Flemming Svensson, Jannet Thorsen, Steffen Ullitz Nutrients Article (1) Background: Zinc is an essential micronutrient and zinc deficiency is associated with immune dysfunction. The neonatal immune system is immature, and therefore an optimal neonatal zinc status may be important. The aim of this study was to investigate the possible association between neonatal whole blood (WB)-Zinc content and several immune markers. (2) Methods: In total, 398 healthy newborns (199 who later developed type 1 diabetes and 199 controls) from the Danish Newborn Screening Biobank had neonatal dried blood spots (NDBS) analyzed for WB-Zinc content and (i) cytokines: Interleukin (IL)-1β, IL-4, IL-6, IL-8, IL-10, IL-12 (p70), interferon gamma, tumor necrosis factor alpha, and transforming growth factor beta; (ii) adipokines: leptin and adiponectin; (iii) other immune response proteins: C-reactive protein (CRP), and mannose-binding lectin (MBL), and soluble triggering receptors expressed on myeloid cells1 (sTREM-1). WB-Zinc content was determined using laser ablation inductively coupled plasma mass spectrometry. For each analyte, the relative change in mean level was modelled by a robust log-normal model regression. (3) Results: No association was found between WB-Zinc content and all the immune response markers in either the unadjusted or adjusted models overall or when stratifying by case status. (4) Conclusions: In healthy Danish neonates, WB-Zinc content was not associated with cytokines, adipokines, CRP, MBL or sTREM, which does not indicate a strong immunological function of neonatal zinc status. MDPI 2019-08-22 /pmc/articles/PMC6769600/ /pubmed/31443415 http://dx.doi.org/10.3390/nu11091980 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kyvsgaard, Julie Nyholm Ellervik, Christina Lindkvist, Emilie Bundgaard Pipper, Christian Bressen Pociot, Flemming Svensson, Jannet Thorsen, Steffen Ullitz Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins |
title | Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins |
title_full | Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins |
title_fullStr | Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins |
title_full_unstemmed | Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins |
title_short | Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins |
title_sort | perinatal whole blood zinc status and cytokines, adipokines, and other immune response proteins |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769600/ https://www.ncbi.nlm.nih.gov/pubmed/31443415 http://dx.doi.org/10.3390/nu11091980 |
work_keys_str_mv | AT kyvsgaardjulienyholm perinatalwholebloodzincstatusandcytokinesadipokinesandotherimmuneresponseproteins AT ellervikchristina perinatalwholebloodzincstatusandcytokinesadipokinesandotherimmuneresponseproteins AT lindkvistemiliebundgaard perinatalwholebloodzincstatusandcytokinesadipokinesandotherimmuneresponseproteins AT pipperchristianbressen perinatalwholebloodzincstatusandcytokinesadipokinesandotherimmuneresponseproteins AT pociotflemming perinatalwholebloodzincstatusandcytokinesadipokinesandotherimmuneresponseproteins AT svenssonjannet perinatalwholebloodzincstatusandcytokinesadipokinesandotherimmuneresponseproteins AT thorsensteffenullitz perinatalwholebloodzincstatusandcytokinesadipokinesandotherimmuneresponseproteins |