Epigenetic Regulation of p21(cip1/waf1) in Human Cancer

p21(cip1/waf1) is a central regulator of cell cycle control and survival. While mutations are rare, it is commonly dysregulated in several human cancers due to epigenetic mechanisms influencing its transcriptional control. These mechanisms include promoter hypermethylation as well as additional path...

Descripción completa

Detalles Bibliográficos
Autores principales: Ocker, Matthias, Al Bitar, Samar, Monteiro, Ana Carolina, Gali-Muhtasib, Hala, Schneider-Stock, Regine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769618/
https://www.ncbi.nlm.nih.gov/pubmed/31514410
http://dx.doi.org/10.3390/cancers11091343
Descripción
Sumario:p21(cip1/waf1) is a central regulator of cell cycle control and survival. While mutations are rare, it is commonly dysregulated in several human cancers due to epigenetic mechanisms influencing its transcriptional control. These mechanisms include promoter hypermethylation as well as additional pathways such as histone acetylation or methylation. The epigenetic regulators include writers, such as DNA methyltransferases (DNMTs); histone acetyltransferases (HATs) and histone lysine methyltransferases; erasers, such as histone deacetylases (HDACs); histone lysine demethylases [e.g., the Lysine Demethylase (KDM) family]; DNA hydroxylases; readers, such as the methyl-CpG-binding proteins (MBPs); and bromodomain-containing proteins, including the bromo- and extraterminal domain (BET) family. We further discuss the roles that long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) play in the epigenetic control of p21(cip1/waf1) expression and its function in human cancers.

Ejemplares similares