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Comparison of Models for Tumor Recurrence after Liver Transplantation for the Patients with Hepatocellular Carcinoma: A Multicenter Long-Term Follow-Up Study

Background and Aims: Several models have been developed to predict tumor the recurrence of hepatocellular carcinoma (HCC) after liver transplantation besides the conventional Milan criteria (MC), including the MoRAL score. This study aimed to compare the prognostication power of the MoRAL score to m...

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Autores principales: Chang, Young, Cho, Yuri, Lee, Jeong-Hoon, Lee, Yun Bin, Cho, Eun Ju, Yu, Su Jong, Sinn, Dong Hyun, Kim, Bo Hyun, Kim, Seoung Hoon, Yi, Nam-Joon, Lee, Kwang-Woong, Kim, Jong Man, Park, Joong-Won, Kim, Yoon Jun, Yoon, Jung-Hwan, Joh, Jae-Won, Suh, Kyung-Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769632/
https://www.ncbi.nlm.nih.gov/pubmed/31484287
http://dx.doi.org/10.3390/cancers11091295
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author Chang, Young
Cho, Yuri
Lee, Jeong-Hoon
Lee, Yun Bin
Cho, Eun Ju
Yu, Su Jong
Sinn, Dong Hyun
Kim, Bo Hyun
Kim, Seoung Hoon
Yi, Nam-Joon
Lee, Kwang-Woong
Kim, Jong Man
Park, Joong-Won
Kim, Yoon Jun
Yoon, Jung-Hwan
Joh, Jae-Won
Suh, Kyung-Suk
author_facet Chang, Young
Cho, Yuri
Lee, Jeong-Hoon
Lee, Yun Bin
Cho, Eun Ju
Yu, Su Jong
Sinn, Dong Hyun
Kim, Bo Hyun
Kim, Seoung Hoon
Yi, Nam-Joon
Lee, Kwang-Woong
Kim, Jong Man
Park, Joong-Won
Kim, Yoon Jun
Yoon, Jung-Hwan
Joh, Jae-Won
Suh, Kyung-Suk
author_sort Chang, Young
collection PubMed
description Background and Aims: Several models have been developed to predict tumor the recurrence of hepatocellular carcinoma (HCC) after liver transplantation besides the conventional Milan criteria (MC), including the MoRAL score. This study aimed to compare the prognostication power of the MoRAL score to most models designed so far in the Eastern and Western countries. Methods: This study included 564 patients who underwent living donor liver transplantation (LDLT) in three large-volume hospitals in Korea. The primary and secondary endpoints were time-to-recurrence, and overall survival (OS), respectively. The performance of the MoRAL score was compared with those of other various Liver transplantation (LT) criteria, including the Milan criteria, University of California San Francisco (UCSF) criteria, up-to-seven criteria, Kyoto criteria, AFP model, total tumor volume/AFP criteria, Metroticket 2.0 model, and Weill Cornell Medical College group model. Results: The median follow-up duration was 78.1 months. Among all models assessed, the MoRAL score showed the best discrimination function for predicting the risk of tumor recurrence after LT, with c-index of 0.78, compared to other models (all p < 0.001). The MoRAL score also represented the best calibration function by Hosmer-Lemeshow test (p = 0.15). Especially in the beyond-MC sub-cohort, the MoRAL score predicted tumor recurrence (c-index, 0.80) and overall survival (OS) (c-index, 0.70) significantly better than any other models (all p < 0.001). When the MoRAL score was low (<314.8), the five-year cumulative risks of tumor recurrence and death were excellent in beyond-MC (27.8%, and 20.5%, respectively) and within-MC (16.3%, and 21.1%, respectively) sub-cohorts. Conclusions: The MoRAL score provides the most refined prognostication for predicting HCC recurrence after LDLT.
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spelling pubmed-67696322019-10-30 Comparison of Models for Tumor Recurrence after Liver Transplantation for the Patients with Hepatocellular Carcinoma: A Multicenter Long-Term Follow-Up Study Chang, Young Cho, Yuri Lee, Jeong-Hoon Lee, Yun Bin Cho, Eun Ju Yu, Su Jong Sinn, Dong Hyun Kim, Bo Hyun Kim, Seoung Hoon Yi, Nam-Joon Lee, Kwang-Woong Kim, Jong Man Park, Joong-Won Kim, Yoon Jun Yoon, Jung-Hwan Joh, Jae-Won Suh, Kyung-Suk Cancers (Basel) Article Background and Aims: Several models have been developed to predict tumor the recurrence of hepatocellular carcinoma (HCC) after liver transplantation besides the conventional Milan criteria (MC), including the MoRAL score. This study aimed to compare the prognostication power of the MoRAL score to most models designed so far in the Eastern and Western countries. Methods: This study included 564 patients who underwent living donor liver transplantation (LDLT) in three large-volume hospitals in Korea. The primary and secondary endpoints were time-to-recurrence, and overall survival (OS), respectively. The performance of the MoRAL score was compared with those of other various Liver transplantation (LT) criteria, including the Milan criteria, University of California San Francisco (UCSF) criteria, up-to-seven criteria, Kyoto criteria, AFP model, total tumor volume/AFP criteria, Metroticket 2.0 model, and Weill Cornell Medical College group model. Results: The median follow-up duration was 78.1 months. Among all models assessed, the MoRAL score showed the best discrimination function for predicting the risk of tumor recurrence after LT, with c-index of 0.78, compared to other models (all p < 0.001). The MoRAL score also represented the best calibration function by Hosmer-Lemeshow test (p = 0.15). Especially in the beyond-MC sub-cohort, the MoRAL score predicted tumor recurrence (c-index, 0.80) and overall survival (OS) (c-index, 0.70) significantly better than any other models (all p < 0.001). When the MoRAL score was low (<314.8), the five-year cumulative risks of tumor recurrence and death were excellent in beyond-MC (27.8%, and 20.5%, respectively) and within-MC (16.3%, and 21.1%, respectively) sub-cohorts. Conclusions: The MoRAL score provides the most refined prognostication for predicting HCC recurrence after LDLT. MDPI 2019-09-03 /pmc/articles/PMC6769632/ /pubmed/31484287 http://dx.doi.org/10.3390/cancers11091295 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chang, Young
Cho, Yuri
Lee, Jeong-Hoon
Lee, Yun Bin
Cho, Eun Ju
Yu, Su Jong
Sinn, Dong Hyun
Kim, Bo Hyun
Kim, Seoung Hoon
Yi, Nam-Joon
Lee, Kwang-Woong
Kim, Jong Man
Park, Joong-Won
Kim, Yoon Jun
Yoon, Jung-Hwan
Joh, Jae-Won
Suh, Kyung-Suk
Comparison of Models for Tumor Recurrence after Liver Transplantation for the Patients with Hepatocellular Carcinoma: A Multicenter Long-Term Follow-Up Study
title Comparison of Models for Tumor Recurrence after Liver Transplantation for the Patients with Hepatocellular Carcinoma: A Multicenter Long-Term Follow-Up Study
title_full Comparison of Models for Tumor Recurrence after Liver Transplantation for the Patients with Hepatocellular Carcinoma: A Multicenter Long-Term Follow-Up Study
title_fullStr Comparison of Models for Tumor Recurrence after Liver Transplantation for the Patients with Hepatocellular Carcinoma: A Multicenter Long-Term Follow-Up Study
title_full_unstemmed Comparison of Models for Tumor Recurrence after Liver Transplantation for the Patients with Hepatocellular Carcinoma: A Multicenter Long-Term Follow-Up Study
title_short Comparison of Models for Tumor Recurrence after Liver Transplantation for the Patients with Hepatocellular Carcinoma: A Multicenter Long-Term Follow-Up Study
title_sort comparison of models for tumor recurrence after liver transplantation for the patients with hepatocellular carcinoma: a multicenter long-term follow-up study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769632/
https://www.ncbi.nlm.nih.gov/pubmed/31484287
http://dx.doi.org/10.3390/cancers11091295
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