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Diffuse Lung Metastases in EGFR-Mutant Non-Small Cell Lung Cancer

Diffuse lung metastases have been reported in non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. The purpose of our study was to compare the incidence of diffuse lung metastases in EGFR-mutant NSCLC and EGFR-wild type NSCLC and to assess other imaging fea...

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Autores principales: Digumarthy, Subba R., Mendoza, Dexter P., Padole, Atul, Chen, Tianqi, Peterson, P. Gabriel, Piotrowska, Zofia, Sequist, Lecia V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769768/
https://www.ncbi.nlm.nih.gov/pubmed/31540242
http://dx.doi.org/10.3390/cancers11091360
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author Digumarthy, Subba R.
Mendoza, Dexter P.
Padole, Atul
Chen, Tianqi
Peterson, P. Gabriel
Piotrowska, Zofia
Sequist, Lecia V.
author_facet Digumarthy, Subba R.
Mendoza, Dexter P.
Padole, Atul
Chen, Tianqi
Peterson, P. Gabriel
Piotrowska, Zofia
Sequist, Lecia V.
author_sort Digumarthy, Subba R.
collection PubMed
description Diffuse lung metastases have been reported in non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. The purpose of our study was to compare the incidence of diffuse lung metastases in EGFR-mutant NSCLC and EGFR-wild type NSCLC and to assess other imaging features that may be associated with diffuse lung metastases in EGFR-mutant NSCLC. Two radiologists retrospectively reviewed pre-treatment imaging of metastatic NSCLC cases with known EGFR mutation status. We assessed the imaging features of the primary tumor and patterns of metastases. The cohort consisted of 217 patients (117 EGFR-mutant, 100 EGFR wild-type). Diffuse lung metastasis was significantly more common in EGFR-mutant NSCLC compared with wild-type (18% vs. 3%, p < 0.01). Among the EGFR-mutant group, diffuse lung metastases were inversely correlated with the presence of a nodule greater than 6 mm other than the primary lung lesion (OR: 0.13, 95% CI: 0.04–0.41, p < 0.01). EGFR mutations in NSCLC are associated with increased frequency of diffuse lung metastases. The presence of diffuse lung metastases in EGFR-mutant NSCLC is also associated with a decreased presence of other larger discrete lung metastases. EGFR mutations in NSCLC should be suspected in the setting of a dominant primary lung mass associated with diffuse lung metastases.
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spelling pubmed-67697682019-10-30 Diffuse Lung Metastases in EGFR-Mutant Non-Small Cell Lung Cancer Digumarthy, Subba R. Mendoza, Dexter P. Padole, Atul Chen, Tianqi Peterson, P. Gabriel Piotrowska, Zofia Sequist, Lecia V. Cancers (Basel) Article Diffuse lung metastases have been reported in non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. The purpose of our study was to compare the incidence of diffuse lung metastases in EGFR-mutant NSCLC and EGFR-wild type NSCLC and to assess other imaging features that may be associated with diffuse lung metastases in EGFR-mutant NSCLC. Two radiologists retrospectively reviewed pre-treatment imaging of metastatic NSCLC cases with known EGFR mutation status. We assessed the imaging features of the primary tumor and patterns of metastases. The cohort consisted of 217 patients (117 EGFR-mutant, 100 EGFR wild-type). Diffuse lung metastasis was significantly more common in EGFR-mutant NSCLC compared with wild-type (18% vs. 3%, p < 0.01). Among the EGFR-mutant group, diffuse lung metastases were inversely correlated with the presence of a nodule greater than 6 mm other than the primary lung lesion (OR: 0.13, 95% CI: 0.04–0.41, p < 0.01). EGFR mutations in NSCLC are associated with increased frequency of diffuse lung metastases. The presence of diffuse lung metastases in EGFR-mutant NSCLC is also associated with a decreased presence of other larger discrete lung metastases. EGFR mutations in NSCLC should be suspected in the setting of a dominant primary lung mass associated with diffuse lung metastases. MDPI 2019-09-13 /pmc/articles/PMC6769768/ /pubmed/31540242 http://dx.doi.org/10.3390/cancers11091360 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Digumarthy, Subba R.
Mendoza, Dexter P.
Padole, Atul
Chen, Tianqi
Peterson, P. Gabriel
Piotrowska, Zofia
Sequist, Lecia V.
Diffuse Lung Metastases in EGFR-Mutant Non-Small Cell Lung Cancer
title Diffuse Lung Metastases in EGFR-Mutant Non-Small Cell Lung Cancer
title_full Diffuse Lung Metastases in EGFR-Mutant Non-Small Cell Lung Cancer
title_fullStr Diffuse Lung Metastases in EGFR-Mutant Non-Small Cell Lung Cancer
title_full_unstemmed Diffuse Lung Metastases in EGFR-Mutant Non-Small Cell Lung Cancer
title_short Diffuse Lung Metastases in EGFR-Mutant Non-Small Cell Lung Cancer
title_sort diffuse lung metastases in egfr-mutant non-small cell lung cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769768/
https://www.ncbi.nlm.nih.gov/pubmed/31540242
http://dx.doi.org/10.3390/cancers11091360
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