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The Therapeutic Potential of Nanoparticles to Reduce Inflammation in Atherosclerosis
Chronic inflammation is one of the main determinants of atherogenesis. The traditional medications for treatment of atherosclerosis are not very efficient in targeting atherosclerotic inflammation. Most of these drugs are non-selective, anti-inflammatory and immunosuppressive agents that have advers...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769786/ https://www.ncbi.nlm.nih.gov/pubmed/31455044 http://dx.doi.org/10.3390/biom9090416 |
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author | Mahdavi Gorabi, Armita Kiaie, Nasim Reiner, Željko Carbone, Federico Montecucco, Fabrizio Sahebkar, Amirhossein |
author_facet | Mahdavi Gorabi, Armita Kiaie, Nasim Reiner, Željko Carbone, Federico Montecucco, Fabrizio Sahebkar, Amirhossein |
author_sort | Mahdavi Gorabi, Armita |
collection | PubMed |
description | Chronic inflammation is one of the main determinants of atherogenesis. The traditional medications for treatment of atherosclerosis are not very efficient in targeting atherosclerotic inflammation. Most of these drugs are non-selective, anti-inflammatory and immunosuppressive agents that have adverse effects and very limited anti-atherosclerotic effects, which limits their systemic administration. New approaches using nanoparticles have been investigated to specifically deliver therapeutic agents directly on atherosclerotic lesions. The use of drug delivery systems, such as polymeric nanoparticles, liposomes, and carbon nanotubes are attractive strategies, but some limitations exist. For instance, nanoparticles may alter the drug kinetics, based on the pathophysiological mechanisms of the diseases. In this review, we will update pathophysiological evidence for the use of nanoparticles to reduce inflammation and potentially prevent atherogenesis in different experimental models. |
format | Online Article Text |
id | pubmed-6769786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67697862019-10-30 The Therapeutic Potential of Nanoparticles to Reduce Inflammation in Atherosclerosis Mahdavi Gorabi, Armita Kiaie, Nasim Reiner, Željko Carbone, Federico Montecucco, Fabrizio Sahebkar, Amirhossein Biomolecules Review Chronic inflammation is one of the main determinants of atherogenesis. The traditional medications for treatment of atherosclerosis are not very efficient in targeting atherosclerotic inflammation. Most of these drugs are non-selective, anti-inflammatory and immunosuppressive agents that have adverse effects and very limited anti-atherosclerotic effects, which limits their systemic administration. New approaches using nanoparticles have been investigated to specifically deliver therapeutic agents directly on atherosclerotic lesions. The use of drug delivery systems, such as polymeric nanoparticles, liposomes, and carbon nanotubes are attractive strategies, but some limitations exist. For instance, nanoparticles may alter the drug kinetics, based on the pathophysiological mechanisms of the diseases. In this review, we will update pathophysiological evidence for the use of nanoparticles to reduce inflammation and potentially prevent atherogenesis in different experimental models. MDPI 2019-08-26 /pmc/articles/PMC6769786/ /pubmed/31455044 http://dx.doi.org/10.3390/biom9090416 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mahdavi Gorabi, Armita Kiaie, Nasim Reiner, Željko Carbone, Federico Montecucco, Fabrizio Sahebkar, Amirhossein The Therapeutic Potential of Nanoparticles to Reduce Inflammation in Atherosclerosis |
title | The Therapeutic Potential of Nanoparticles to Reduce Inflammation in Atherosclerosis |
title_full | The Therapeutic Potential of Nanoparticles to Reduce Inflammation in Atherosclerosis |
title_fullStr | The Therapeutic Potential of Nanoparticles to Reduce Inflammation in Atherosclerosis |
title_full_unstemmed | The Therapeutic Potential of Nanoparticles to Reduce Inflammation in Atherosclerosis |
title_short | The Therapeutic Potential of Nanoparticles to Reduce Inflammation in Atherosclerosis |
title_sort | therapeutic potential of nanoparticles to reduce inflammation in atherosclerosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769786/ https://www.ncbi.nlm.nih.gov/pubmed/31455044 http://dx.doi.org/10.3390/biom9090416 |
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