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Effectiveness of Non-Animal Chondroitin Sulfate Supplementation in the Treatment of Moderate Knee Osteoarthritis in a Group of Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Study

Osteoarthritis (OA) is the most common form of arthritis in the world and is characterized by pain, various disabilities and loss of quality of life. Chondroitin sulfate (CS) is recommended as first-line therapy. CS of non-animal origin is of great interest for safety and sustainability reasons. Thi...

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Autores principales: Rondanelli, Mariangela, Braschi, Valentina, Gasparri, Clara, Nichetti, Mara, Faliva, Milena Anna, Peroni, Gabriella, Naso, Maurizio, Iannello, Giancarlo, Spadaccini, Daniele, Miraglia, Niccolò, Putignano, Pietro, Alalwan, Tariq A., Perna, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769794/
https://www.ncbi.nlm.nih.gov/pubmed/31470599
http://dx.doi.org/10.3390/nu11092027
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author Rondanelli, Mariangela
Braschi, Valentina
Gasparri, Clara
Nichetti, Mara
Faliva, Milena Anna
Peroni, Gabriella
Naso, Maurizio
Iannello, Giancarlo
Spadaccini, Daniele
Miraglia, Niccolò
Putignano, Pietro
Alalwan, Tariq A.
Perna, Simone
author_facet Rondanelli, Mariangela
Braschi, Valentina
Gasparri, Clara
Nichetti, Mara
Faliva, Milena Anna
Peroni, Gabriella
Naso, Maurizio
Iannello, Giancarlo
Spadaccini, Daniele
Miraglia, Niccolò
Putignano, Pietro
Alalwan, Tariq A.
Perna, Simone
author_sort Rondanelli, Mariangela
collection PubMed
description Osteoarthritis (OA) is the most common form of arthritis in the world and is characterized by pain, various disabilities and loss of quality of life. Chondroitin sulfate (CS) is recommended as first-line therapy. CS of non-animal origin is of great interest for safety and sustainability reasons. This study aims to investigate the anti-inflammatory effects, anti-pain and ability-enhancement of a short-term supplementation with non-animal CS in overweight subjects with OA. In a randomized, double-blind, placebo-controlled pilot study, 60 overweight adults with symptomatic OA were allocated to consume 600 mg of non-animal CS (n = 30) or a placebo (n = 30) daily for 12 consecutive weeks. The assessment of knee-pain, quality of life, related inflammation markers and body composition was performed at 0, 4 and 12 weeks. The Tegner Lysholm Knee Scoring (TLKS) scale of the experimental group showed a statistically significant increase (+10.64 points; confidence interval (95% confidence interval (CI) 5.57; 15.70; p < 0.01), while the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score decreased (−12.24 points; CI 95% −16.01; −8.38; p < 0.01). The results also showed a decrease in the C-reactive protein (CRP) level (−0.14 mg/dL, CI 95% −0.26; −0.04; p < 0.01) and erythrocyte sedimentation rate (ESR) level (−5.01 mm/h, CI 95% −9.18; −0.84, p < 0.01) as well as the visual analogue scale (VAS) score in both knees. In conclusion, this pilot study demonstrates the effectiveness of non-animal CS supplementation in overweight subjects with knee OA in improving knee function, pain and inflammation markers.
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spelling pubmed-67697942019-10-30 Effectiveness of Non-Animal Chondroitin Sulfate Supplementation in the Treatment of Moderate Knee Osteoarthritis in a Group of Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Study Rondanelli, Mariangela Braschi, Valentina Gasparri, Clara Nichetti, Mara Faliva, Milena Anna Peroni, Gabriella Naso, Maurizio Iannello, Giancarlo Spadaccini, Daniele Miraglia, Niccolò Putignano, Pietro Alalwan, Tariq A. Perna, Simone Nutrients Article Osteoarthritis (OA) is the most common form of arthritis in the world and is characterized by pain, various disabilities and loss of quality of life. Chondroitin sulfate (CS) is recommended as first-line therapy. CS of non-animal origin is of great interest for safety and sustainability reasons. This study aims to investigate the anti-inflammatory effects, anti-pain and ability-enhancement of a short-term supplementation with non-animal CS in overweight subjects with OA. In a randomized, double-blind, placebo-controlled pilot study, 60 overweight adults with symptomatic OA were allocated to consume 600 mg of non-animal CS (n = 30) or a placebo (n = 30) daily for 12 consecutive weeks. The assessment of knee-pain, quality of life, related inflammation markers and body composition was performed at 0, 4 and 12 weeks. The Tegner Lysholm Knee Scoring (TLKS) scale of the experimental group showed a statistically significant increase (+10.64 points; confidence interval (95% confidence interval (CI) 5.57; 15.70; p < 0.01), while the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score decreased (−12.24 points; CI 95% −16.01; −8.38; p < 0.01). The results also showed a decrease in the C-reactive protein (CRP) level (−0.14 mg/dL, CI 95% −0.26; −0.04; p < 0.01) and erythrocyte sedimentation rate (ESR) level (−5.01 mm/h, CI 95% −9.18; −0.84, p < 0.01) as well as the visual analogue scale (VAS) score in both knees. In conclusion, this pilot study demonstrates the effectiveness of non-animal CS supplementation in overweight subjects with knee OA in improving knee function, pain and inflammation markers. MDPI 2019-08-29 /pmc/articles/PMC6769794/ /pubmed/31470599 http://dx.doi.org/10.3390/nu11092027 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rondanelli, Mariangela
Braschi, Valentina
Gasparri, Clara
Nichetti, Mara
Faliva, Milena Anna
Peroni, Gabriella
Naso, Maurizio
Iannello, Giancarlo
Spadaccini, Daniele
Miraglia, Niccolò
Putignano, Pietro
Alalwan, Tariq A.
Perna, Simone
Effectiveness of Non-Animal Chondroitin Sulfate Supplementation in the Treatment of Moderate Knee Osteoarthritis in a Group of Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
title Effectiveness of Non-Animal Chondroitin Sulfate Supplementation in the Treatment of Moderate Knee Osteoarthritis in a Group of Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
title_full Effectiveness of Non-Animal Chondroitin Sulfate Supplementation in the Treatment of Moderate Knee Osteoarthritis in a Group of Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
title_fullStr Effectiveness of Non-Animal Chondroitin Sulfate Supplementation in the Treatment of Moderate Knee Osteoarthritis in a Group of Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
title_full_unstemmed Effectiveness of Non-Animal Chondroitin Sulfate Supplementation in the Treatment of Moderate Knee Osteoarthritis in a Group of Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
title_short Effectiveness of Non-Animal Chondroitin Sulfate Supplementation in the Treatment of Moderate Knee Osteoarthritis in a Group of Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
title_sort effectiveness of non-animal chondroitin sulfate supplementation in the treatment of moderate knee osteoarthritis in a group of overweight subjects: a randomized, double-blind, placebo-controlled pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769794/
https://www.ncbi.nlm.nih.gov/pubmed/31470599
http://dx.doi.org/10.3390/nu11092027
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