Cargando…
Activation of Kv7 Potassium Channels Inhibits Intracellular Ca(2+) Increases Triggered By TRPV1-Mediated Pain-Inducing Stimuli in F11 Immortalized Sensory Neurons
Kv7.2-Kv7.5 channels mediate the M-current (I(KM)), a K(+)-selective current regulating neuronal excitability and representing an attractive target for pharmacological therapy against hyperexcitability diseases such as pain. Kv7 channels interact functionally with transient receptor potential vanill...
Autores principales: | Ambrosino, Paolo, Soldovieri, Maria Virginia, Di Zazzo, Erika, Paventi, Gianluca, Iannotti, Fabio Arturo, Mosca, Ilaria, Miceli, Francesco, Franco, Cristina, Canzoniero, Lorella Maria Teresa, Taglialatela, Maurizio |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769798/ https://www.ncbi.nlm.nih.gov/pubmed/31487785 http://dx.doi.org/10.3390/ijms20184322 |
Ejemplares similares
-
Epileptic Encephalopathy In A Patient With A Novel Variant In The Kv7.2 S(2) Transmembrane Segment: Clinical, Genetic, and Functional Features
por: Soldovieri, Maria Virginia, et al.
Publicado: (2019) -
Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine
por: Barrese, Vincenzo, et al.
Publicado: (2010) -
Early-onset epileptic encephalopathy caused by a reduced sensitivity of Kv7.2 potassium channels to phosphatidylinositol 4,5-bisphosphate
por: Soldovieri, Maria Virginia, et al.
Publicado: (2016) -
Differential Regulation of PI(4,5)P(2) Sensitivity of Kv7.2 and Kv7.3 Channels by Calmodulin
por: Gomis-Perez, Carolina, et al.
Publicado: (2017) -
The Voltage-Sensing Domain of K(v)7.2 Channels as a Molecular Target for Epilepsy-Causing Mutations and Anticonvulsants
por: Miceli, Francesco, et al.
Publicado: (2011)