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Loosening of Side-Chain Packing Associated with Perturbations in Peripheral Dynamics Induced by the D76N Mutation of β(2)-Microglobulin Revealed by Pressure-NMR and Molecular Dynamic Simulations
β(2)-Microglobulin (β(2)m) is the causative protein of dialysis-related amyloidosis, and its D76N variant is less stable and more prone to aggregation. Since their crystal structures are indistinguishable from each other, enhanced amyloidogenicity induced by the mutation may be attributed to changes...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769805/ https://www.ncbi.nlm.nih.gov/pubmed/31527472 http://dx.doi.org/10.3390/biom9090491 |