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Predicting cardiac electrical response to sodium-channel blockade and Brugada syndrome using polygenic risk scores

AIMS: Sodium-channel blockers (SCBs) are associated with arrhythmia, but variability of cardiac electrical response remains unexplained. We sought to identify predictors of ajmaline-induced PR and QRS changes and Type I Brugada syndrome (BrS) electrocardiogram (ECG). METHODS AND RESULTS: In 1368 pat...

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Detalles Bibliográficos
Autores principales:	Tadros, Rafik, Tan, Hanno L, el Mathari, Sulayman, Kors, Jan A, Postema, Pieter G, Lahrouchi, Najim, Beekman, Leander, Radivojkov-Blagojevic, Milena, Amin, Ahmad S, Meitinger, Thomas, Tanck, Michael W, Wilde, Arthur A, Bezzina, Connie R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Clinical Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769824/ https://www.ncbi.nlm.nih.gov/pubmed/31504448 http://dx.doi.org/10.1093/eurheartj/ehz435

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