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The Effect of 12 Weeks of β-Hydroxy-β-Methyl-Butyrate Supplementation after Liver Transplantation: A Pilot Randomized Controlled Study

Sarcopenia is a frequent complication in liver transplant (LT) recipients. β-hydroxy-β-methyl-butyrate (HMB) has the potential to increase muscle-performance and tropism. Our study aims at evaluating the effect on muscle mass and functioning, and the safety of 12 weeks of HMB supplementation in pati...

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Autores principales: Lattanzi, Barbara, Giusto, Michela, Albanese, Carlina, Mennini, Gianluca, D’Ambrosio, Daria, Farcomeni, Alessio, Ginanni Corradini, Stefano, Rossi, Massimo, Merli, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769827/
https://www.ncbi.nlm.nih.gov/pubmed/31546969
http://dx.doi.org/10.3390/nu11092259
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author Lattanzi, Barbara
Giusto, Michela
Albanese, Carlina
Mennini, Gianluca
D’Ambrosio, Daria
Farcomeni, Alessio
Ginanni Corradini, Stefano
Rossi, Massimo
Merli, Manuela
author_facet Lattanzi, Barbara
Giusto, Michela
Albanese, Carlina
Mennini, Gianluca
D’Ambrosio, Daria
Farcomeni, Alessio
Ginanni Corradini, Stefano
Rossi, Massimo
Merli, Manuela
author_sort Lattanzi, Barbara
collection PubMed
description Sarcopenia is a frequent complication in liver transplant (LT) recipients. β-hydroxy-β-methyl-butyrate (HMB) has the potential to increase muscle-performance and tropism. Our study aims at evaluating the effect on muscle mass and functioning, and the safety of 12 weeks of HMB supplementation in patients after LT. This is a pilot, randomized study. Male patients undergoing LT were randomly assigned to the HMB or control group. A diet interview, anthropometry and body composition by dual energy X-ray absorptiometry (DEXA) were performed at enrollment (T0), after 12 weeks (T1) and after 12 months (T12). Twenty-two liver transplant male patients were enrolled in the study: 12 in the HMB group and 10 as the control group. At enrollment, demographic, clinical and nutritional data were similar. According to the appendicular skeletal muscle index, sarcopenia was present in 50% of patients. The appendix skeletal muscle mass index (ASMI) showed a significant increase at T1 and T12 in HMB patients, but not in controls. The mid-arm muscle-circumference and hand grip strength also increased at T1 and T12 versus T0 only in the HMB group. No side effects were reported in either group. The study showed a positive effect of HMB in the recovery of muscle mass and strength after LT. HMB supplement in patients after LT was safe and well tolerated.
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spelling pubmed-67698272019-10-30 The Effect of 12 Weeks of β-Hydroxy-β-Methyl-Butyrate Supplementation after Liver Transplantation: A Pilot Randomized Controlled Study Lattanzi, Barbara Giusto, Michela Albanese, Carlina Mennini, Gianluca D’Ambrosio, Daria Farcomeni, Alessio Ginanni Corradini, Stefano Rossi, Massimo Merli, Manuela Nutrients Article Sarcopenia is a frequent complication in liver transplant (LT) recipients. β-hydroxy-β-methyl-butyrate (HMB) has the potential to increase muscle-performance and tropism. Our study aims at evaluating the effect on muscle mass and functioning, and the safety of 12 weeks of HMB supplementation in patients after LT. This is a pilot, randomized study. Male patients undergoing LT were randomly assigned to the HMB or control group. A diet interview, anthropometry and body composition by dual energy X-ray absorptiometry (DEXA) were performed at enrollment (T0), after 12 weeks (T1) and after 12 months (T12). Twenty-two liver transplant male patients were enrolled in the study: 12 in the HMB group and 10 as the control group. At enrollment, demographic, clinical and nutritional data were similar. According to the appendicular skeletal muscle index, sarcopenia was present in 50% of patients. The appendix skeletal muscle mass index (ASMI) showed a significant increase at T1 and T12 in HMB patients, but not in controls. The mid-arm muscle-circumference and hand grip strength also increased at T1 and T12 versus T0 only in the HMB group. No side effects were reported in either group. The study showed a positive effect of HMB in the recovery of muscle mass and strength after LT. HMB supplement in patients after LT was safe and well tolerated. MDPI 2019-09-19 /pmc/articles/PMC6769827/ /pubmed/31546969 http://dx.doi.org/10.3390/nu11092259 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lattanzi, Barbara
Giusto, Michela
Albanese, Carlina
Mennini, Gianluca
D’Ambrosio, Daria
Farcomeni, Alessio
Ginanni Corradini, Stefano
Rossi, Massimo
Merli, Manuela
The Effect of 12 Weeks of β-Hydroxy-β-Methyl-Butyrate Supplementation after Liver Transplantation: A Pilot Randomized Controlled Study
title The Effect of 12 Weeks of β-Hydroxy-β-Methyl-Butyrate Supplementation after Liver Transplantation: A Pilot Randomized Controlled Study
title_full The Effect of 12 Weeks of β-Hydroxy-β-Methyl-Butyrate Supplementation after Liver Transplantation: A Pilot Randomized Controlled Study
title_fullStr The Effect of 12 Weeks of β-Hydroxy-β-Methyl-Butyrate Supplementation after Liver Transplantation: A Pilot Randomized Controlled Study
title_full_unstemmed The Effect of 12 Weeks of β-Hydroxy-β-Methyl-Butyrate Supplementation after Liver Transplantation: A Pilot Randomized Controlled Study
title_short The Effect of 12 Weeks of β-Hydroxy-β-Methyl-Butyrate Supplementation after Liver Transplantation: A Pilot Randomized Controlled Study
title_sort effect of 12 weeks of β-hydroxy-β-methyl-butyrate supplementation after liver transplantation: a pilot randomized controlled study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769827/
https://www.ncbi.nlm.nih.gov/pubmed/31546969
http://dx.doi.org/10.3390/nu11092259
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