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Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment
TGFβ (transforming growth factor-beta) is a pleotropic cytokine with contrasting effects in cancer. In normal tissue and early tumours, TGFβ acts as a tumour suppressor, limiting proliferation and inducing apoptosis. However, these effects are eventually abrogated by the loss or inactivation of down...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769837/ https://www.ncbi.nlm.nih.gov/pubmed/31438626 http://dx.doi.org/10.3390/cancers11091221 |