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Selenium-Binding Protein 1 Indicates Myocardial Stress and Risk for Adverse Outcome in Cardiac Surgery

Selenium-binding protein 1 (SELENBP1) is an intracellular protein that has been detected in the circulation in response to myocardial infarction. Hypoxia and cardiac surgery affect selenoprotein expression and selenium (Se) status. For this reason, we decided to analyze circulating SELENBP1 concentr...

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Autores principales: Kühn-Heid, Ellen C. D., Kühn, Eike C., Ney, Julia, Wendt, Sebastian, Seelig, Julian, Schwiebert, Christian, Minich, Waldemar B., Stoppe, Christian, Schomburg, Lutz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769850/
https://www.ncbi.nlm.nih.gov/pubmed/31450690
http://dx.doi.org/10.3390/nu11092005
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author Kühn-Heid, Ellen C. D.
Kühn, Eike C.
Ney, Julia
Wendt, Sebastian
Seelig, Julian
Schwiebert, Christian
Minich, Waldemar B.
Stoppe, Christian
Schomburg, Lutz
author_facet Kühn-Heid, Ellen C. D.
Kühn, Eike C.
Ney, Julia
Wendt, Sebastian
Seelig, Julian
Schwiebert, Christian
Minich, Waldemar B.
Stoppe, Christian
Schomburg, Lutz
author_sort Kühn-Heid, Ellen C. D.
collection PubMed
description Selenium-binding protein 1 (SELENBP1) is an intracellular protein that has been detected in the circulation in response to myocardial infarction. Hypoxia and cardiac surgery affect selenoprotein expression and selenium (Se) status. For this reason, we decided to analyze circulating SELENBP1 concentrations in patients (n = 75) necessitating cardioplegia and a cardiopulmonary bypass (CPB) during the course of the cardiac surgery. Serum samples were collected at seven time-points spanning the full surgical process. SELENBP1 was quantified by a highly sensitive newly developed immunological assay. Serum concentrations of SELENBP1 increased markedly during the intervention and showed a positive association with the duration of ischemia (ρ = 0.6, p < 0.0001). Elevated serum SELENBP1 concentrations at 1 h after arrival at the intensive care unit (post-surgery) were predictive to identify patients at risk of adverse outcome (death, bradycardia or cerebral ischemia, “endpoint 1”; OR 29.9, CI 3.3–268.8, p = 0.00027). Circulating SELENBP1 during intervention (2 min after reperfusion or 15 min after weaning from the CPB) correlated positively with an established marker of myocardial infarction (CK-MB) measured after the intervention (each with ρ = 0.5, p < 0.0001). We concluded that serum concentrations of SELENBP1 were strongly associated with cardiac arrest and the duration of myocardial ischemia already early during surgery, thereby constituting a novel and promising quantitative marker for myocardial hypoxia, with a high potential to improve diagnostics and prediction in combination with the established clinical parameters.
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spelling pubmed-67698502019-10-30 Selenium-Binding Protein 1 Indicates Myocardial Stress and Risk for Adverse Outcome in Cardiac Surgery Kühn-Heid, Ellen C. D. Kühn, Eike C. Ney, Julia Wendt, Sebastian Seelig, Julian Schwiebert, Christian Minich, Waldemar B. Stoppe, Christian Schomburg, Lutz Nutrients Article Selenium-binding protein 1 (SELENBP1) is an intracellular protein that has been detected in the circulation in response to myocardial infarction. Hypoxia and cardiac surgery affect selenoprotein expression and selenium (Se) status. For this reason, we decided to analyze circulating SELENBP1 concentrations in patients (n = 75) necessitating cardioplegia and a cardiopulmonary bypass (CPB) during the course of the cardiac surgery. Serum samples were collected at seven time-points spanning the full surgical process. SELENBP1 was quantified by a highly sensitive newly developed immunological assay. Serum concentrations of SELENBP1 increased markedly during the intervention and showed a positive association with the duration of ischemia (ρ = 0.6, p < 0.0001). Elevated serum SELENBP1 concentrations at 1 h after arrival at the intensive care unit (post-surgery) were predictive to identify patients at risk of adverse outcome (death, bradycardia or cerebral ischemia, “endpoint 1”; OR 29.9, CI 3.3–268.8, p = 0.00027). Circulating SELENBP1 during intervention (2 min after reperfusion or 15 min after weaning from the CPB) correlated positively with an established marker of myocardial infarction (CK-MB) measured after the intervention (each with ρ = 0.5, p < 0.0001). We concluded that serum concentrations of SELENBP1 were strongly associated with cardiac arrest and the duration of myocardial ischemia already early during surgery, thereby constituting a novel and promising quantitative marker for myocardial hypoxia, with a high potential to improve diagnostics and prediction in combination with the established clinical parameters. MDPI 2019-08-25 /pmc/articles/PMC6769850/ /pubmed/31450690 http://dx.doi.org/10.3390/nu11092005 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kühn-Heid, Ellen C. D.
Kühn, Eike C.
Ney, Julia
Wendt, Sebastian
Seelig, Julian
Schwiebert, Christian
Minich, Waldemar B.
Stoppe, Christian
Schomburg, Lutz
Selenium-Binding Protein 1 Indicates Myocardial Stress and Risk for Adverse Outcome in Cardiac Surgery
title Selenium-Binding Protein 1 Indicates Myocardial Stress and Risk for Adverse Outcome in Cardiac Surgery
title_full Selenium-Binding Protein 1 Indicates Myocardial Stress and Risk for Adverse Outcome in Cardiac Surgery
title_fullStr Selenium-Binding Protein 1 Indicates Myocardial Stress and Risk for Adverse Outcome in Cardiac Surgery
title_full_unstemmed Selenium-Binding Protein 1 Indicates Myocardial Stress and Risk for Adverse Outcome in Cardiac Surgery
title_short Selenium-Binding Protein 1 Indicates Myocardial Stress and Risk for Adverse Outcome in Cardiac Surgery
title_sort selenium-binding protein 1 indicates myocardial stress and risk for adverse outcome in cardiac surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769850/
https://www.ncbi.nlm.nih.gov/pubmed/31450690
http://dx.doi.org/10.3390/nu11092005
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