PKR Promotes Oxidative Stress and Apoptosis of Human Articular Chondrocytes by Causing Mitochondrial Dysfunction through p38 MAPK Activation—PKR Activation Causes Apoptosis in Human Chondrocytes

Osteoarthritis (OA) is one of the most common types of arthritis in the elderly people. It has been known that chondrocyte apoptosis occurs in OA cartilage; however, the detailed molecular mechanism remains unclear. In the current study, we aimed to elucidate the role of double-stranded RNA-dependen...

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Detalles Bibliográficos
Autores principales: Ma, Ching-Hou, Wu, Chin-Hsien, Jou, I-Ming, Tu, Yuan-Kun, Hung, Ching-Hsia, Chou, Wan-Ching, Chang, Yun-Ching, Hsieh, Pei-Ling, Tsai, Kun-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769915/
https://www.ncbi.nlm.nih.gov/pubmed/31484360
http://dx.doi.org/10.3390/antiox8090370

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