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Raw Garlic Consumption and Risk of Liver Cancer: A Population-Based Case-Control Study in Eastern China

Although the major risk factors for liver cancer have been established, preventive factors for liver cancer have not been fully explored. We evaluated the association between raw garlic consumption and liver cancer in a large population-based case-control study in Eastern China. The study was conduc...

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Autores principales: Liu, Xing, Baecker, Aileen, Wu, Ming, Zhou, Jin-Yi, Yang, Jie, Han, Ren-Qiang, Wang, Pei-Hua, Liu, Ai-Min, Gu, Xiaoping, Zhang, Xiao-Feng, Wang, Xu-Shan, Su, Ming, Hu, Xu, Sun, Zheng, Li, Gang, Jin, Zi-Yi, Jung, Su Yon, Mu, Lina, He, Na, Lu, Qing-Yi, Li, Liming, Zhao, Jin-Kou, Zhang, Zuo-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769938/
https://www.ncbi.nlm.nih.gov/pubmed/31480423
http://dx.doi.org/10.3390/nu11092038
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author Liu, Xing
Baecker, Aileen
Wu, Ming
Zhou, Jin-Yi
Yang, Jie
Han, Ren-Qiang
Wang, Pei-Hua
Liu, Ai-Min
Gu, Xiaoping
Zhang, Xiao-Feng
Wang, Xu-Shan
Su, Ming
Hu, Xu
Sun, Zheng
Li, Gang
Jin, Zi-Yi
Jung, Su Yon
Mu, Lina
He, Na
Lu, Qing-Yi
Li, Liming
Zhao, Jin-Kou
Zhang, Zuo-Feng
author_facet Liu, Xing
Baecker, Aileen
Wu, Ming
Zhou, Jin-Yi
Yang, Jie
Han, Ren-Qiang
Wang, Pei-Hua
Liu, Ai-Min
Gu, Xiaoping
Zhang, Xiao-Feng
Wang, Xu-Shan
Su, Ming
Hu, Xu
Sun, Zheng
Li, Gang
Jin, Zi-Yi
Jung, Su Yon
Mu, Lina
He, Na
Lu, Qing-Yi
Li, Liming
Zhao, Jin-Kou
Zhang, Zuo-Feng
author_sort Liu, Xing
collection PubMed
description Although the major risk factors for liver cancer have been established, preventive factors for liver cancer have not been fully explored. We evaluated the association between raw garlic consumption and liver cancer in a large population-based case-control study in Eastern China. The study was conducted in Jiangsu, China, from 2003 to 2010. A total of 2011 incident liver cancer cases and 7933 randomly selected population-controls were interviewed. Epidemiological data including raw garlic intake and other exposures were collected, and serum markers of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection were assayed. Overall, eating raw garlic twice or more per week was inversely associated with liver cancer, with an adjusted odds ratio (aOR) of 0.77 (95% confidence interval (CI): 0.62–0.96) compared to those ingesting no raw garlic or less than twice per week. In stratified analyses, high intake of raw garlic was inversely associated with liver cancer among Hepatitis B surface antigen (HBsAg) negative individuals, frequent alcohol drinkers, those having history of eating mold-contaminated food or drinking raw water, and those without family history of liver cancer. Marginal interactions on an additive scale were observed between low raw garlic intake and HBsAg positivity (attributable proportion due to interaction (AP) = 0.31, 95% CI: -0.01–0.62) and heavy alcohol drinking (AP = 0.28, 95% CI: 0.00–0.57). Raw garlic consumption is inversely associated with liver cancer. Such an association shed some light on the potential etiologic role of garlic intake on liver cancer, which in turn might provide a possible dietary intervention to reduce liver cancer in Chinese population.
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spelling pubmed-67699382019-10-30 Raw Garlic Consumption and Risk of Liver Cancer: A Population-Based Case-Control Study in Eastern China Liu, Xing Baecker, Aileen Wu, Ming Zhou, Jin-Yi Yang, Jie Han, Ren-Qiang Wang, Pei-Hua Liu, Ai-Min Gu, Xiaoping Zhang, Xiao-Feng Wang, Xu-Shan Su, Ming Hu, Xu Sun, Zheng Li, Gang Jin, Zi-Yi Jung, Su Yon Mu, Lina He, Na Lu, Qing-Yi Li, Liming Zhao, Jin-Kou Zhang, Zuo-Feng Nutrients Article Although the major risk factors for liver cancer have been established, preventive factors for liver cancer have not been fully explored. We evaluated the association between raw garlic consumption and liver cancer in a large population-based case-control study in Eastern China. The study was conducted in Jiangsu, China, from 2003 to 2010. A total of 2011 incident liver cancer cases and 7933 randomly selected population-controls were interviewed. Epidemiological data including raw garlic intake and other exposures were collected, and serum markers of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection were assayed. Overall, eating raw garlic twice or more per week was inversely associated with liver cancer, with an adjusted odds ratio (aOR) of 0.77 (95% confidence interval (CI): 0.62–0.96) compared to those ingesting no raw garlic or less than twice per week. In stratified analyses, high intake of raw garlic was inversely associated with liver cancer among Hepatitis B surface antigen (HBsAg) negative individuals, frequent alcohol drinkers, those having history of eating mold-contaminated food or drinking raw water, and those without family history of liver cancer. Marginal interactions on an additive scale were observed between low raw garlic intake and HBsAg positivity (attributable proportion due to interaction (AP) = 0.31, 95% CI: -0.01–0.62) and heavy alcohol drinking (AP = 0.28, 95% CI: 0.00–0.57). Raw garlic consumption is inversely associated with liver cancer. Such an association shed some light on the potential etiologic role of garlic intake on liver cancer, which in turn might provide a possible dietary intervention to reduce liver cancer in Chinese population. MDPI 2019-08-31 /pmc/articles/PMC6769938/ /pubmed/31480423 http://dx.doi.org/10.3390/nu11092038 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Xing
Baecker, Aileen
Wu, Ming
Zhou, Jin-Yi
Yang, Jie
Han, Ren-Qiang
Wang, Pei-Hua
Liu, Ai-Min
Gu, Xiaoping
Zhang, Xiao-Feng
Wang, Xu-Shan
Su, Ming
Hu, Xu
Sun, Zheng
Li, Gang
Jin, Zi-Yi
Jung, Su Yon
Mu, Lina
He, Na
Lu, Qing-Yi
Li, Liming
Zhao, Jin-Kou
Zhang, Zuo-Feng
Raw Garlic Consumption and Risk of Liver Cancer: A Population-Based Case-Control Study in Eastern China
title Raw Garlic Consumption and Risk of Liver Cancer: A Population-Based Case-Control Study in Eastern China
title_full Raw Garlic Consumption and Risk of Liver Cancer: A Population-Based Case-Control Study in Eastern China
title_fullStr Raw Garlic Consumption and Risk of Liver Cancer: A Population-Based Case-Control Study in Eastern China
title_full_unstemmed Raw Garlic Consumption and Risk of Liver Cancer: A Population-Based Case-Control Study in Eastern China
title_short Raw Garlic Consumption and Risk of Liver Cancer: A Population-Based Case-Control Study in Eastern China
title_sort raw garlic consumption and risk of liver cancer: a population-based case-control study in eastern china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769938/
https://www.ncbi.nlm.nih.gov/pubmed/31480423
http://dx.doi.org/10.3390/nu11092038
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