Cargando…
Prognostic Factors for Event-Free Survival in Pediatric Patients with Hepatoblastoma Based on the 2017 PRETEXT and CHIC-HS Systems
This study aimed to evaluate the prognostic value of variables used in the 2017 PRE-Treatment EXTent of tumor (PRETEXT) system and the Children’s Hepatic tumors International Collaboration-Hepatoblastoma Stratification (CHIC-HS) system in pediatric patients with hepatoblastoma. A retrospective analy...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769992/ https://www.ncbi.nlm.nih.gov/pubmed/31540387 http://dx.doi.org/10.3390/cancers11091387 |
_version_ | 1783455366963527680 |
---|---|
author | Yoon, Hee Mang Hwang, Jisun Kim, Kyung Won Namgoong, Jung-Man Kim, Dae Yeon Koh, Kyung-Nam Kim, Hyery Cho, Young Ah |
author_facet | Yoon, Hee Mang Hwang, Jisun Kim, Kyung Won Namgoong, Jung-Man Kim, Dae Yeon Koh, Kyung-Nam Kim, Hyery Cho, Young Ah |
author_sort | Yoon, Hee Mang |
collection | PubMed |
description | This study aimed to evaluate the prognostic value of variables used in the 2017 PRE-Treatment EXTent of tumor (PRETEXT) system and the Children’s Hepatic tumors International Collaboration-Hepatoblastoma Stratification (CHIC-HS) system in pediatric patients with hepatoblastoma. A retrospective analysis of data from the pediatric hepatoblastoma registry of a tertiary referral center was conducted to evaluate the clinical and imaging variables (annotation factors) of the PRETEXT staging system. The primary outcome was event-free survival (EFS). Data from 84 patients (mean age: 2.9 ± 3.5 years) identified between 1998 and 2017 were included. Univariable Cox proportional hazards analysis revealed that PRETEXT annotation factors P (portal vein involvement), F (multifocality of tumor), and M (distant metastasis) showed a significant negative association with EFS. Multivariable Cox proportional hazard analysis showed that factor F was the strongest predictor (HR (hazard ratio), 2.908; 95% CI (confidence interval), 1.061–7.972; p = 0.038), whereas factor M showed borderline significance (HR, 2.416; 95% CI, 0.918–6.354; p = 0.074). The prediction model based on F and M (F + M) showed good performance to predict EFS (C-statistic, 0.734; 95% CI, 0.612–0.854). In conclusion, the PRETEXT annotation factor F was the strongest predictor of EFS, and the F + M model showed good performance to predict EFS in pediatric patients with hepatoblastoma. |
format | Online Article Text |
id | pubmed-6769992 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67699922019-10-30 Prognostic Factors for Event-Free Survival in Pediatric Patients with Hepatoblastoma Based on the 2017 PRETEXT and CHIC-HS Systems Yoon, Hee Mang Hwang, Jisun Kim, Kyung Won Namgoong, Jung-Man Kim, Dae Yeon Koh, Kyung-Nam Kim, Hyery Cho, Young Ah Cancers (Basel) Article This study aimed to evaluate the prognostic value of variables used in the 2017 PRE-Treatment EXTent of tumor (PRETEXT) system and the Children’s Hepatic tumors International Collaboration-Hepatoblastoma Stratification (CHIC-HS) system in pediatric patients with hepatoblastoma. A retrospective analysis of data from the pediatric hepatoblastoma registry of a tertiary referral center was conducted to evaluate the clinical and imaging variables (annotation factors) of the PRETEXT staging system. The primary outcome was event-free survival (EFS). Data from 84 patients (mean age: 2.9 ± 3.5 years) identified between 1998 and 2017 were included. Univariable Cox proportional hazards analysis revealed that PRETEXT annotation factors P (portal vein involvement), F (multifocality of tumor), and M (distant metastasis) showed a significant negative association with EFS. Multivariable Cox proportional hazard analysis showed that factor F was the strongest predictor (HR (hazard ratio), 2.908; 95% CI (confidence interval), 1.061–7.972; p = 0.038), whereas factor M showed borderline significance (HR, 2.416; 95% CI, 0.918–6.354; p = 0.074). The prediction model based on F and M (F + M) showed good performance to predict EFS (C-statistic, 0.734; 95% CI, 0.612–0.854). In conclusion, the PRETEXT annotation factor F was the strongest predictor of EFS, and the F + M model showed good performance to predict EFS in pediatric patients with hepatoblastoma. MDPI 2019-09-18 /pmc/articles/PMC6769992/ /pubmed/31540387 http://dx.doi.org/10.3390/cancers11091387 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yoon, Hee Mang Hwang, Jisun Kim, Kyung Won Namgoong, Jung-Man Kim, Dae Yeon Koh, Kyung-Nam Kim, Hyery Cho, Young Ah Prognostic Factors for Event-Free Survival in Pediatric Patients with Hepatoblastoma Based on the 2017 PRETEXT and CHIC-HS Systems |
title | Prognostic Factors for Event-Free Survival in Pediatric Patients with Hepatoblastoma Based on the 2017 PRETEXT and CHIC-HS Systems |
title_full | Prognostic Factors for Event-Free Survival in Pediatric Patients with Hepatoblastoma Based on the 2017 PRETEXT and CHIC-HS Systems |
title_fullStr | Prognostic Factors for Event-Free Survival in Pediatric Patients with Hepatoblastoma Based on the 2017 PRETEXT and CHIC-HS Systems |
title_full_unstemmed | Prognostic Factors for Event-Free Survival in Pediatric Patients with Hepatoblastoma Based on the 2017 PRETEXT and CHIC-HS Systems |
title_short | Prognostic Factors for Event-Free Survival in Pediatric Patients with Hepatoblastoma Based on the 2017 PRETEXT and CHIC-HS Systems |
title_sort | prognostic factors for event-free survival in pediatric patients with hepatoblastoma based on the 2017 pretext and chic-hs systems |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769992/ https://www.ncbi.nlm.nih.gov/pubmed/31540387 http://dx.doi.org/10.3390/cancers11091387 |
work_keys_str_mv | AT yoonheemang prognosticfactorsforeventfreesurvivalinpediatricpatientswithhepatoblastomabasedonthe2017pretextandchichssystems AT hwangjisun prognosticfactorsforeventfreesurvivalinpediatricpatientswithhepatoblastomabasedonthe2017pretextandchichssystems AT kimkyungwon prognosticfactorsforeventfreesurvivalinpediatricpatientswithhepatoblastomabasedonthe2017pretextandchichssystems AT namgoongjungman prognosticfactorsforeventfreesurvivalinpediatricpatientswithhepatoblastomabasedonthe2017pretextandchichssystems AT kimdaeyeon prognosticfactorsforeventfreesurvivalinpediatricpatientswithhepatoblastomabasedonthe2017pretextandchichssystems AT kohkyungnam prognosticfactorsforeventfreesurvivalinpediatricpatientswithhepatoblastomabasedonthe2017pretextandchichssystems AT kimhyery prognosticfactorsforeventfreesurvivalinpediatricpatientswithhepatoblastomabasedonthe2017pretextandchichssystems AT choyoungah prognosticfactorsforeventfreesurvivalinpediatricpatientswithhepatoblastomabasedonthe2017pretextandchichssystems |