Cargando…

Animal Models of Undernutrition and Enteropathy as Tools for Assessment of Nutritional Intervention

Undernutrition is a major public health problem leading to 1 in 5 of all deaths in children under 5 years. Undernutrition leads to growth stunting and/or wasting and is often associated with environmental enteric dysfunction (EED). EED mechanisms leading to growth failure include intestinal hyperper...

Descripción completa

Detalles Bibliográficos
Autores principales: Salameh, Emmeline, Morel, Fanny B., Zeilani, Mamane, Déchelotte, Pierre, Marion-Letellier, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770013/
https://www.ncbi.nlm.nih.gov/pubmed/31527523
http://dx.doi.org/10.3390/nu11092233
_version_ 1783455371890786304
author Salameh, Emmeline
Morel, Fanny B.
Zeilani, Mamane
Déchelotte, Pierre
Marion-Letellier, Rachel
author_facet Salameh, Emmeline
Morel, Fanny B.
Zeilani, Mamane
Déchelotte, Pierre
Marion-Letellier, Rachel
author_sort Salameh, Emmeline
collection PubMed
description Undernutrition is a major public health problem leading to 1 in 5 of all deaths in children under 5 years. Undernutrition leads to growth stunting and/or wasting and is often associated with environmental enteric dysfunction (EED). EED mechanisms leading to growth failure include intestinal hyperpermeability, villus blunting, malabsorption and gut inflammation. As non-invasive methods for investigating gut function in undernourished children are limited, pre-clinical models are relevant to elucidating the pathophysiological processes involved in undernutrition and EED, and to identifying novel therapeutic strategies. In many published models, undernutrition was induced using protein or micronutrient deficient diets, but these experimental models were not associated with EED. Enteropathy models mainly used gastrointestinal injury triggers. These models are presented in this review. We found only a few studies investigating the combination of undernutrition and enteropathy. This highlights the need for further developments to establish an experimental model reproducing the impact of undernutrition and enteropathy on growth, intestinal hyperpermeability and inflammation, that could be suitable for preclinical evaluation of innovative therapeutic intervention.
format Online
Article
Text
id pubmed-6770013
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-67700132019-10-30 Animal Models of Undernutrition and Enteropathy as Tools for Assessment of Nutritional Intervention Salameh, Emmeline Morel, Fanny B. Zeilani, Mamane Déchelotte, Pierre Marion-Letellier, Rachel Nutrients Review Undernutrition is a major public health problem leading to 1 in 5 of all deaths in children under 5 years. Undernutrition leads to growth stunting and/or wasting and is often associated with environmental enteric dysfunction (EED). EED mechanisms leading to growth failure include intestinal hyperpermeability, villus blunting, malabsorption and gut inflammation. As non-invasive methods for investigating gut function in undernourished children are limited, pre-clinical models are relevant to elucidating the pathophysiological processes involved in undernutrition and EED, and to identifying novel therapeutic strategies. In many published models, undernutrition was induced using protein or micronutrient deficient diets, but these experimental models were not associated with EED. Enteropathy models mainly used gastrointestinal injury triggers. These models are presented in this review. We found only a few studies investigating the combination of undernutrition and enteropathy. This highlights the need for further developments to establish an experimental model reproducing the impact of undernutrition and enteropathy on growth, intestinal hyperpermeability and inflammation, that could be suitable for preclinical evaluation of innovative therapeutic intervention. MDPI 2019-09-16 /pmc/articles/PMC6770013/ /pubmed/31527523 http://dx.doi.org/10.3390/nu11092233 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Salameh, Emmeline
Morel, Fanny B.
Zeilani, Mamane
Déchelotte, Pierre
Marion-Letellier, Rachel
Animal Models of Undernutrition and Enteropathy as Tools for Assessment of Nutritional Intervention
title Animal Models of Undernutrition and Enteropathy as Tools for Assessment of Nutritional Intervention
title_full Animal Models of Undernutrition and Enteropathy as Tools for Assessment of Nutritional Intervention
title_fullStr Animal Models of Undernutrition and Enteropathy as Tools for Assessment of Nutritional Intervention
title_full_unstemmed Animal Models of Undernutrition and Enteropathy as Tools for Assessment of Nutritional Intervention
title_short Animal Models of Undernutrition and Enteropathy as Tools for Assessment of Nutritional Intervention
title_sort animal models of undernutrition and enteropathy as tools for assessment of nutritional intervention
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770013/
https://www.ncbi.nlm.nih.gov/pubmed/31527523
http://dx.doi.org/10.3390/nu11092233
work_keys_str_mv AT salamehemmeline animalmodelsofundernutritionandenteropathyastoolsforassessmentofnutritionalintervention
AT morelfannyb animalmodelsofundernutritionandenteropathyastoolsforassessmentofnutritionalintervention
AT zeilanimamane animalmodelsofundernutritionandenteropathyastoolsforassessmentofnutritionalintervention
AT dechelottepierre animalmodelsofundernutritionandenteropathyastoolsforassessmentofnutritionalintervention
AT marionletellierrachel animalmodelsofundernutritionandenteropathyastoolsforassessmentofnutritionalintervention