Cargando…
Animal Models of Undernutrition and Enteropathy as Tools for Assessment of Nutritional Intervention
Undernutrition is a major public health problem leading to 1 in 5 of all deaths in children under 5 years. Undernutrition leads to growth stunting and/or wasting and is often associated with environmental enteric dysfunction (EED). EED mechanisms leading to growth failure include intestinal hyperper...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770013/ https://www.ncbi.nlm.nih.gov/pubmed/31527523 http://dx.doi.org/10.3390/nu11092233 |
_version_ | 1783455371890786304 |
---|---|
author | Salameh, Emmeline Morel, Fanny B. Zeilani, Mamane Déchelotte, Pierre Marion-Letellier, Rachel |
author_facet | Salameh, Emmeline Morel, Fanny B. Zeilani, Mamane Déchelotte, Pierre Marion-Letellier, Rachel |
author_sort | Salameh, Emmeline |
collection | PubMed |
description | Undernutrition is a major public health problem leading to 1 in 5 of all deaths in children under 5 years. Undernutrition leads to growth stunting and/or wasting and is often associated with environmental enteric dysfunction (EED). EED mechanisms leading to growth failure include intestinal hyperpermeability, villus blunting, malabsorption and gut inflammation. As non-invasive methods for investigating gut function in undernourished children are limited, pre-clinical models are relevant to elucidating the pathophysiological processes involved in undernutrition and EED, and to identifying novel therapeutic strategies. In many published models, undernutrition was induced using protein or micronutrient deficient diets, but these experimental models were not associated with EED. Enteropathy models mainly used gastrointestinal injury triggers. These models are presented in this review. We found only a few studies investigating the combination of undernutrition and enteropathy. This highlights the need for further developments to establish an experimental model reproducing the impact of undernutrition and enteropathy on growth, intestinal hyperpermeability and inflammation, that could be suitable for preclinical evaluation of innovative therapeutic intervention. |
format | Online Article Text |
id | pubmed-6770013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67700132019-10-30 Animal Models of Undernutrition and Enteropathy as Tools for Assessment of Nutritional Intervention Salameh, Emmeline Morel, Fanny B. Zeilani, Mamane Déchelotte, Pierre Marion-Letellier, Rachel Nutrients Review Undernutrition is a major public health problem leading to 1 in 5 of all deaths in children under 5 years. Undernutrition leads to growth stunting and/or wasting and is often associated with environmental enteric dysfunction (EED). EED mechanisms leading to growth failure include intestinal hyperpermeability, villus blunting, malabsorption and gut inflammation. As non-invasive methods for investigating gut function in undernourished children are limited, pre-clinical models are relevant to elucidating the pathophysiological processes involved in undernutrition and EED, and to identifying novel therapeutic strategies. In many published models, undernutrition was induced using protein or micronutrient deficient diets, but these experimental models were not associated with EED. Enteropathy models mainly used gastrointestinal injury triggers. These models are presented in this review. We found only a few studies investigating the combination of undernutrition and enteropathy. This highlights the need for further developments to establish an experimental model reproducing the impact of undernutrition and enteropathy on growth, intestinal hyperpermeability and inflammation, that could be suitable for preclinical evaluation of innovative therapeutic intervention. MDPI 2019-09-16 /pmc/articles/PMC6770013/ /pubmed/31527523 http://dx.doi.org/10.3390/nu11092233 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Salameh, Emmeline Morel, Fanny B. Zeilani, Mamane Déchelotte, Pierre Marion-Letellier, Rachel Animal Models of Undernutrition and Enteropathy as Tools for Assessment of Nutritional Intervention |
title | Animal Models of Undernutrition and Enteropathy as Tools for Assessment of Nutritional Intervention |
title_full | Animal Models of Undernutrition and Enteropathy as Tools for Assessment of Nutritional Intervention |
title_fullStr | Animal Models of Undernutrition and Enteropathy as Tools for Assessment of Nutritional Intervention |
title_full_unstemmed | Animal Models of Undernutrition and Enteropathy as Tools for Assessment of Nutritional Intervention |
title_short | Animal Models of Undernutrition and Enteropathy as Tools for Assessment of Nutritional Intervention |
title_sort | animal models of undernutrition and enteropathy as tools for assessment of nutritional intervention |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770013/ https://www.ncbi.nlm.nih.gov/pubmed/31527523 http://dx.doi.org/10.3390/nu11092233 |
work_keys_str_mv | AT salamehemmeline animalmodelsofundernutritionandenteropathyastoolsforassessmentofnutritionalintervention AT morelfannyb animalmodelsofundernutritionandenteropathyastoolsforassessmentofnutritionalintervention AT zeilanimamane animalmodelsofundernutritionandenteropathyastoolsforassessmentofnutritionalintervention AT dechelottepierre animalmodelsofundernutritionandenteropathyastoolsforassessmentofnutritionalintervention AT marionletellierrachel animalmodelsofundernutritionandenteropathyastoolsforassessmentofnutritionalintervention |