Cargando…

Cyclosporin A Increases Mitochondrial Buffering of Calcium: An Additional Mechanism in Delaying Mitochondrial Permeability Transition Pore Opening

Regulation of mitochondrial free Ca(2+) is critically important for cellular homeostasis. An increase in mitochondrial matrix free Ca(2+) concentration ([Ca(2+)](m)) predisposes mitochondria to opening of the permeability transition pore (mPTP). Opening of the pore can be delayed by cyclosporin A (C...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mishra, Jyotsna, Davani, Ariea J., Natarajan, Gayathri K., Kwok, Wai-Meng, Stowe, David F., Camara, Amadou K.S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770067/ https://www.ncbi.nlm.nih.gov/pubmed/31500337 http://dx.doi.org/10.3390/cells8091052

Ejemplares similares

LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling
por: Natarajan, Gayathri K., et al.
Publicado: (2021)

Total Matrix Ca(2+) Modulates Ca(2+) Efflux via the Ca(2+)/H(+) Exchanger in Cardiac Mitochondria
por: Natarajan, Gayathri K., et al.
Publicado: (2020)

Hypothermia Prevents Cardiac Dysfunction during Acute Ischemia Reperfusion by Maintaining Mitochondrial Bioenergetics and by Promoting Hexokinase II Binding to Mitochondria
por: Sun, Jie, et al.
Publicado: (2022)

Differential effects of buffer pH on Ca(2+)-induced ROS emission with inhibited mitochondrial complexes I and III
por: Lindsay, Daniel P., et al.
Publicado: (2015)

Infarct size reduction by cyclosporine A at reperfusion involves inhibition of the mitochondrial permeability transition pore but does not improve mitochondrial respiration
por: Gedik, Nilguen, et al.
Publicado: (2013)

Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II
por: Haloi, Nandan, et al.
Publicado: (2021)

PPARγ-Independent Side Effects of Thiazolidinediones on Mitochondrial Redox State in Rat Isolated Hearts
por: Riess, Matthias L., et al.
Publicado: (2020)

Editorial: Mitochondrial Exchangers and Transporters in Cell Survival and Death
por: Kwok, Wai-Meng, et al.
Publicado: (2021)

Mitochondrial Approaches to Protect Against Cardiac Ischemia and Reperfusion Injury
por: Camara, Amadou K. S., et al.
Publicado: (2011)

Mitochondrial Cyclosporine A-Independent Palmitate/Ca(2+)-Induced Permeability Transition Pore (PA-mPT Pore) and Its Role in Mitochondrial Function and Protection against Calcium Overload and Glutamate Toxicity
por: Mironova, Galina D., et al.
Publicado: (2021)

Regulation of mitochondrial permeability transition pore by PINK1
por: Giaime, Emilie, et al.
Publicado: (2012)

The mitochondrial permeability transition pore: a mystery solved?
por: Bernardi, Paolo
Publicado: (2013)

Dual dynamics of mitochondrial permeability transition pore opening
por: Wacquier, Benjamin, et al.
Publicado: (2020)

The mitochondrial permeability transition pore is a dispensable element for mitochondrial calcium efflux
por: De Marchi, Elena, et al.
Publicado: (2014)

The Reduction in the Mitochondrial Membrane Potential in Aging: The Role of the Mitochondrial Permeability Transition Pore
por: Rottenberg, Hagai
Publicado: (2023)

Knockout of VDAC1 in H9c2 Cells Promotes Oxidative Stress-Induced Cell Apoptosis through Decreased Mitochondrial Hexokinase II Binding and Enhanced Glycolytic Stress
por: Yang, Meiying, et al.
Publicado: (2020)

Nanoparticle-Mediated Targeting of Cyclosporine A Enhances Cardioprotection Against Ischemia-Reperfusion Injury Through Inhibition of Mitochondrial Permeability Transition Pore Opening
por: Ikeda, Gentaro, et al.
Publicado: (2016)

The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore
por: Rottenberg, Hagai, et al.
Publicado: (2017)

The mitochondrial permeability transition pore activates the mitochondrial unfolded protein response and promotes aging
por: Angeli, Suzanne, et al.
Publicado: (2021)

The roles of phosphate and the phosphate carrier in the mitochondrial permeability transition pore
por: Varanyuwatana, Pinadda, et al.
Publicado: (2012)

Regulation of the mitochondrial permeability transition pore and its effects on aging
por: Pellegrino-Coppola, Damiano
Publicado: (2020)

Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease
por: Pérez, María José, et al.
Publicado: (2018)

Modulation of mitochondrial ion transport by inorganic polyphosphate - essential role in mitochondrial permeability transition pore
por: Baev, Artyom Y., et al.
Publicado: (2016)

Mitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injury
por: Agarwal, Bhawana, et al.
Publicado: (2014)

Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease
por: Quintanilla, Rodrigo A, et al.
Publicado: (2013)

The mitochondrial permeability transition pore and its adaptive responses in tumor cells
por: Rasola, Andrea, et al.
Publicado: (2014)

Other bricks for the correct construction of the mitochondrial permeability transition pore complex
por: Morciano, Giampaolo, et al.
Publicado: (2017)

Involvement of Multidrug Resistance Modulators in the Regulation of the Mitochondrial Permeability Transition Pore
por: Fedotcheva, Tatiana, et al.
Publicado: (2022)

Investigating the Mitochondrial Permeability Transition Pore in Disease Phenotypes and Drug Screening
por: Bhosale, Gauri, et al.
Publicado: (2019)

The Haves and Have-Nots: The Mitochondrial Permeability Transition Pore across Species
por: Frigo, Elena, et al.
Publicado: (2023)

Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target
por: Camara, Amadou K. S., et al.
Publicado: (2017)

Inorganic polyphosphate is a potent activator of the mitochondrial permeability transition pore in cardiac myocytes
por: Seidlmayer, Lea K., et al.
Publicado: (2012)

Mitochondrial permeability transition pore as a selective target for anti-cancer therapy
por: Suh, Dong H., et al.
Publicado: (2013)

The P66Shc/Mitochondrial Permeability Transition Pore Pathway Determines Neurodegeneration
por: Savino, Costanza, et al.
Publicado: (2013)

Commentary: SPG7 is an essential and conserved component of the mitochondrial permeability transition pore
por: Bernardi, Paolo, et al.
Publicado: (2015)

The mitochondrial permeability transition pore: Molecular nature and role as a target in cardioprotection
por: Bernardi, Paolo, et al.
Publicado: (2015)

Inhibition of mitochondrial permeability transition pore restores the cardioprotection by postconditioning in diabetic hearts
por: Najafi, Moslem, et al.
Publicado: (2014)

The Mitochondrial Permeability Transition Pore and Cancer: Molecular Mechanisms Involved in Cell Death
por: Bonora, Massimo, et al.
Publicado: (2014)

Mitochondrial DNA Mutations Cause Disease, Apoptosis, and Permeability Transition Pore Dysfunction
por: Justin, L. Mott, et al.
Publicado: (2001)

Targeting the mitochondrial permeability transition pore in traumatic central nervous system injury
por: Springer, Joe E., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_da2cr3i2p2277tene8nr90n2m9