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Highlights in Resistance Mechanism Pathways for Combination Therapy
Combination chemotherapy has been a mainstay in cancer treatment for the last 60 years. Although the mechanisms of action and signaling pathways affected by most treatments with single antineoplastic agents might be relatively well understood, most combinations remain poorly understood. This review...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770082/ https://www.ncbi.nlm.nih.gov/pubmed/31480389 http://dx.doi.org/10.3390/cells8091013 |
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author | Delou, João M. A. Souza, Alana S. O. Souza, Leonel C. M. Borges, Helena L. |
author_facet | Delou, João M. A. Souza, Alana S. O. Souza, Leonel C. M. Borges, Helena L. |
author_sort | Delou, João M. A. |
collection | PubMed |
description | Combination chemotherapy has been a mainstay in cancer treatment for the last 60 years. Although the mechanisms of action and signaling pathways affected by most treatments with single antineoplastic agents might be relatively well understood, most combinations remain poorly understood. This review presents the most common alterations of signaling pathways in response to cytotoxic and targeted anticancer drug treatments, with a discussion of how the knowledge of signaling pathways might support and orient the development of innovative strategies for anticancer combination therapy. The ultimate goal is to highlight possible strategies of chemotherapy combinations based on the signaling pathways associated with the resistance mechanisms against anticancer drugs to maximize the selective induction of cancer cell death. We consider this review an extensive compilation of updated known information on chemotherapy resistance mechanisms to promote new combination therapies to be to discussed and tested. |
format | Online Article Text |
id | pubmed-6770082 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67700822019-10-30 Highlights in Resistance Mechanism Pathways for Combination Therapy Delou, João M. A. Souza, Alana S. O. Souza, Leonel C. M. Borges, Helena L. Cells Review Combination chemotherapy has been a mainstay in cancer treatment for the last 60 years. Although the mechanisms of action and signaling pathways affected by most treatments with single antineoplastic agents might be relatively well understood, most combinations remain poorly understood. This review presents the most common alterations of signaling pathways in response to cytotoxic and targeted anticancer drug treatments, with a discussion of how the knowledge of signaling pathways might support and orient the development of innovative strategies for anticancer combination therapy. The ultimate goal is to highlight possible strategies of chemotherapy combinations based on the signaling pathways associated with the resistance mechanisms against anticancer drugs to maximize the selective induction of cancer cell death. We consider this review an extensive compilation of updated known information on chemotherapy resistance mechanisms to promote new combination therapies to be to discussed and tested. MDPI 2019-08-30 /pmc/articles/PMC6770082/ /pubmed/31480389 http://dx.doi.org/10.3390/cells8091013 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Delou, João M. A. Souza, Alana S. O. Souza, Leonel C. M. Borges, Helena L. Highlights in Resistance Mechanism Pathways for Combination Therapy |
title | Highlights in Resistance Mechanism Pathways for Combination Therapy |
title_full | Highlights in Resistance Mechanism Pathways for Combination Therapy |
title_fullStr | Highlights in Resistance Mechanism Pathways for Combination Therapy |
title_full_unstemmed | Highlights in Resistance Mechanism Pathways for Combination Therapy |
title_short | Highlights in Resistance Mechanism Pathways for Combination Therapy |
title_sort | highlights in resistance mechanism pathways for combination therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770082/ https://www.ncbi.nlm.nih.gov/pubmed/31480389 http://dx.doi.org/10.3390/cells8091013 |
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