Cargando…
Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis
We recently observed reduced autophagy in Crohn’s disease patients and an anti-inflammatory effect of autophagy stimulation in murine colitis, but both anti- and pro-fibrotic effects are associated with autophagy stimulation in different tissues, and fibrosis is a frequent complication of Crohn’s di...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770118/ https://www.ncbi.nlm.nih.gov/pubmed/31540207 http://dx.doi.org/10.3390/cells8091078 |
_version_ | 1783455396597334016 |
---|---|
author | Cosin-Roger, Jesus Canet, Francisco Macias-Ceja, Dulce C. Gisbert-Ferrándiz, Laura Ortiz-Masiá, Dolores Esplugues, Juan V. Alós, Rafael Navarro, Francisco Barrachina, María D. Calatayud, Sara |
author_facet | Cosin-Roger, Jesus Canet, Francisco Macias-Ceja, Dulce C. Gisbert-Ferrándiz, Laura Ortiz-Masiá, Dolores Esplugues, Juan V. Alós, Rafael Navarro, Francisco Barrachina, María D. Calatayud, Sara |
author_sort | Cosin-Roger, Jesus |
collection | PubMed |
description | We recently observed reduced autophagy in Crohn’s disease patients and an anti-inflammatory effect of autophagy stimulation in murine colitis, but both anti- and pro-fibrotic effects are associated with autophagy stimulation in different tissues, and fibrosis is a frequent complication of Crohn’s disease. Thus, we analyzed the effects of pharmacological modulation of autophagy in a murine model of intestinal fibrosis and detected that autophagy inhibition aggravates, while autophagy stimulation prevents, fibrosis. These effects are associated with changes in inflammation and in collagen degradation in primary fibroblasts. Thus, pharmacological stimulation of autophagy may be useful against intestinal fibrosis. |
format | Online Article Text |
id | pubmed-6770118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67701182019-10-30 Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis Cosin-Roger, Jesus Canet, Francisco Macias-Ceja, Dulce C. Gisbert-Ferrándiz, Laura Ortiz-Masiá, Dolores Esplugues, Juan V. Alós, Rafael Navarro, Francisco Barrachina, María D. Calatayud, Sara Cells Brief Report We recently observed reduced autophagy in Crohn’s disease patients and an anti-inflammatory effect of autophagy stimulation in murine colitis, but both anti- and pro-fibrotic effects are associated with autophagy stimulation in different tissues, and fibrosis is a frequent complication of Crohn’s disease. Thus, we analyzed the effects of pharmacological modulation of autophagy in a murine model of intestinal fibrosis and detected that autophagy inhibition aggravates, while autophagy stimulation prevents, fibrosis. These effects are associated with changes in inflammation and in collagen degradation in primary fibroblasts. Thus, pharmacological stimulation of autophagy may be useful against intestinal fibrosis. MDPI 2019-09-13 /pmc/articles/PMC6770118/ /pubmed/31540207 http://dx.doi.org/10.3390/cells8091078 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Cosin-Roger, Jesus Canet, Francisco Macias-Ceja, Dulce C. Gisbert-Ferrándiz, Laura Ortiz-Masiá, Dolores Esplugues, Juan V. Alós, Rafael Navarro, Francisco Barrachina, María D. Calatayud, Sara Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis |
title | Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis |
title_full | Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis |
title_fullStr | Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis |
title_full_unstemmed | Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis |
title_short | Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis |
title_sort | autophagy stimulation as a potential strategy against intestinal fibrosis |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770118/ https://www.ncbi.nlm.nih.gov/pubmed/31540207 http://dx.doi.org/10.3390/cells8091078 |
work_keys_str_mv | AT cosinrogerjesus autophagystimulationasapotentialstrategyagainstintestinalfibrosis AT canetfrancisco autophagystimulationasapotentialstrategyagainstintestinalfibrosis AT maciascejadulcec autophagystimulationasapotentialstrategyagainstintestinalfibrosis AT gisbertferrandizlaura autophagystimulationasapotentialstrategyagainstintestinalfibrosis AT ortizmasiadolores autophagystimulationasapotentialstrategyagainstintestinalfibrosis AT espluguesjuanv autophagystimulationasapotentialstrategyagainstintestinalfibrosis AT alosrafael autophagystimulationasapotentialstrategyagainstintestinalfibrosis AT navarrofrancisco autophagystimulationasapotentialstrategyagainstintestinalfibrosis AT barrachinamariad autophagystimulationasapotentialstrategyagainstintestinalfibrosis AT calatayudsara autophagystimulationasapotentialstrategyagainstintestinalfibrosis |