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Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis

We recently observed reduced autophagy in Crohn’s disease patients and an anti-inflammatory effect of autophagy stimulation in murine colitis, but both anti- and pro-fibrotic effects are associated with autophagy stimulation in different tissues, and fibrosis is a frequent complication of Crohn’s di...

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Autores principales: Cosin-Roger, Jesus, Canet, Francisco, Macias-Ceja, Dulce C., Gisbert-Ferrándiz, Laura, Ortiz-Masiá, Dolores, Esplugues, Juan V., Alós, Rafael, Navarro, Francisco, Barrachina, María D., Calatayud, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770118/
https://www.ncbi.nlm.nih.gov/pubmed/31540207
http://dx.doi.org/10.3390/cells8091078
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author Cosin-Roger, Jesus
Canet, Francisco
Macias-Ceja, Dulce C.
Gisbert-Ferrándiz, Laura
Ortiz-Masiá, Dolores
Esplugues, Juan V.
Alós, Rafael
Navarro, Francisco
Barrachina, María D.
Calatayud, Sara
author_facet Cosin-Roger, Jesus
Canet, Francisco
Macias-Ceja, Dulce C.
Gisbert-Ferrándiz, Laura
Ortiz-Masiá, Dolores
Esplugues, Juan V.
Alós, Rafael
Navarro, Francisco
Barrachina, María D.
Calatayud, Sara
author_sort Cosin-Roger, Jesus
collection PubMed
description We recently observed reduced autophagy in Crohn’s disease patients and an anti-inflammatory effect of autophagy stimulation in murine colitis, but both anti- and pro-fibrotic effects are associated with autophagy stimulation in different tissues, and fibrosis is a frequent complication of Crohn’s disease. Thus, we analyzed the effects of pharmacological modulation of autophagy in a murine model of intestinal fibrosis and detected that autophagy inhibition aggravates, while autophagy stimulation prevents, fibrosis. These effects are associated with changes in inflammation and in collagen degradation in primary fibroblasts. Thus, pharmacological stimulation of autophagy may be useful against intestinal fibrosis.
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spelling pubmed-67701182019-10-30 Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis Cosin-Roger, Jesus Canet, Francisco Macias-Ceja, Dulce C. Gisbert-Ferrándiz, Laura Ortiz-Masiá, Dolores Esplugues, Juan V. Alós, Rafael Navarro, Francisco Barrachina, María D. Calatayud, Sara Cells Brief Report We recently observed reduced autophagy in Crohn’s disease patients and an anti-inflammatory effect of autophagy stimulation in murine colitis, but both anti- and pro-fibrotic effects are associated with autophagy stimulation in different tissues, and fibrosis is a frequent complication of Crohn’s disease. Thus, we analyzed the effects of pharmacological modulation of autophagy in a murine model of intestinal fibrosis and detected that autophagy inhibition aggravates, while autophagy stimulation prevents, fibrosis. These effects are associated with changes in inflammation and in collagen degradation in primary fibroblasts. Thus, pharmacological stimulation of autophagy may be useful against intestinal fibrosis. MDPI 2019-09-13 /pmc/articles/PMC6770118/ /pubmed/31540207 http://dx.doi.org/10.3390/cells8091078 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Cosin-Roger, Jesus
Canet, Francisco
Macias-Ceja, Dulce C.
Gisbert-Ferrándiz, Laura
Ortiz-Masiá, Dolores
Esplugues, Juan V.
Alós, Rafael
Navarro, Francisco
Barrachina, María D.
Calatayud, Sara
Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis
title Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis
title_full Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis
title_fullStr Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis
title_full_unstemmed Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis
title_short Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis
title_sort autophagy stimulation as a potential strategy against intestinal fibrosis
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770118/
https://www.ncbi.nlm.nih.gov/pubmed/31540207
http://dx.doi.org/10.3390/cells8091078
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