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Interdisciplinary Weight Loss and Lifestyle Intervention for Obstructive Sleep Apnoea in Adults: Rationale, Design and Methodology of the INTERAPNEA Study

Obesity is a major risk factor for obstructive sleep apnoea (OSA), the most common sleep-disordered breathing related to neurocognitive and metabolic syndromes, type II diabetes, and cardiovascular diseases. Although strongly recommended for this condition, there are no studies on the effectiveness...

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Autores principales: Carneiro-Barrera, Almudena, Amaro-Gahete, Francisco J., Díaz-Román, Amparo, Guillén-Riquelme, Alejandro, Jurado-Fasoli, Lucas, Sáez-Roca, Germán, Martín-Carrasco, Carlos, Ruiz, Jonatan R., Buela-Casal, Gualberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770131/
https://www.ncbi.nlm.nih.gov/pubmed/31540168
http://dx.doi.org/10.3390/nu11092227
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author Carneiro-Barrera, Almudena
Amaro-Gahete, Francisco J.
Díaz-Román, Amparo
Guillén-Riquelme, Alejandro
Jurado-Fasoli, Lucas
Sáez-Roca, Germán
Martín-Carrasco, Carlos
Ruiz, Jonatan R.
Buela-Casal, Gualberto
author_facet Carneiro-Barrera, Almudena
Amaro-Gahete, Francisco J.
Díaz-Román, Amparo
Guillén-Riquelme, Alejandro
Jurado-Fasoli, Lucas
Sáez-Roca, Germán
Martín-Carrasco, Carlos
Ruiz, Jonatan R.
Buela-Casal, Gualberto
author_sort Carneiro-Barrera, Almudena
collection PubMed
description Obesity is a major risk factor for obstructive sleep apnoea (OSA), the most common sleep-disordered breathing related to neurocognitive and metabolic syndromes, type II diabetes, and cardiovascular diseases. Although strongly recommended for this condition, there are no studies on the effectiveness of an interdisciplinary weight loss and lifestyle intervention including nutrition, exercise, sleep hygiene, and smoking and alcohol cessation. INTERAPNEA is a randomised controlled trial with a two-arm parallel design aimed at determining the effects of an interdisciplinary tailored weight loss and lifestyle intervention on OSA outcomes. The study will include 84 males aged 18–65 with a body mass index of ≥25 kg/m(2) and severe to moderate OSA randomly assigned to usual care (i.e., continuous positive airway pressure), or interdisciplinary weight loss and lifestyle intervention combined with usual care. Outcomes will be measured at baseline, intervention end-point, and six-month post-intervention, including apnoea-hypopnoea index (primary outcome), other neurophysical and cardiorespiratory polysomnographic outcomes, sleep quality, daily functioning and mood, body weight and composition, physical fitness, blood biomarkers, health-related quality of life, and cost-effectiveness. INTERAPNEA may serve to establish a cost-effective treatment not only for the improvement of OSA and its vast and severe comorbidities, but also for a potential remission of this condition.
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spelling pubmed-67701312019-10-30 Interdisciplinary Weight Loss and Lifestyle Intervention for Obstructive Sleep Apnoea in Adults: Rationale, Design and Methodology of the INTERAPNEA Study Carneiro-Barrera, Almudena Amaro-Gahete, Francisco J. Díaz-Román, Amparo Guillén-Riquelme, Alejandro Jurado-Fasoli, Lucas Sáez-Roca, Germán Martín-Carrasco, Carlos Ruiz, Jonatan R. Buela-Casal, Gualberto Nutrients Article Obesity is a major risk factor for obstructive sleep apnoea (OSA), the most common sleep-disordered breathing related to neurocognitive and metabolic syndromes, type II diabetes, and cardiovascular diseases. Although strongly recommended for this condition, there are no studies on the effectiveness of an interdisciplinary weight loss and lifestyle intervention including nutrition, exercise, sleep hygiene, and smoking and alcohol cessation. INTERAPNEA is a randomised controlled trial with a two-arm parallel design aimed at determining the effects of an interdisciplinary tailored weight loss and lifestyle intervention on OSA outcomes. The study will include 84 males aged 18–65 with a body mass index of ≥25 kg/m(2) and severe to moderate OSA randomly assigned to usual care (i.e., continuous positive airway pressure), or interdisciplinary weight loss and lifestyle intervention combined with usual care. Outcomes will be measured at baseline, intervention end-point, and six-month post-intervention, including apnoea-hypopnoea index (primary outcome), other neurophysical and cardiorespiratory polysomnographic outcomes, sleep quality, daily functioning and mood, body weight and composition, physical fitness, blood biomarkers, health-related quality of life, and cost-effectiveness. INTERAPNEA may serve to establish a cost-effective treatment not only for the improvement of OSA and its vast and severe comorbidities, but also for a potential remission of this condition. MDPI 2019-09-15 /pmc/articles/PMC6770131/ /pubmed/31540168 http://dx.doi.org/10.3390/nu11092227 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Carneiro-Barrera, Almudena
Amaro-Gahete, Francisco J.
Díaz-Román, Amparo
Guillén-Riquelme, Alejandro
Jurado-Fasoli, Lucas
Sáez-Roca, Germán
Martín-Carrasco, Carlos
Ruiz, Jonatan R.
Buela-Casal, Gualberto
Interdisciplinary Weight Loss and Lifestyle Intervention for Obstructive Sleep Apnoea in Adults: Rationale, Design and Methodology of the INTERAPNEA Study
title Interdisciplinary Weight Loss and Lifestyle Intervention for Obstructive Sleep Apnoea in Adults: Rationale, Design and Methodology of the INTERAPNEA Study
title_full Interdisciplinary Weight Loss and Lifestyle Intervention for Obstructive Sleep Apnoea in Adults: Rationale, Design and Methodology of the INTERAPNEA Study
title_fullStr Interdisciplinary Weight Loss and Lifestyle Intervention for Obstructive Sleep Apnoea in Adults: Rationale, Design and Methodology of the INTERAPNEA Study
title_full_unstemmed Interdisciplinary Weight Loss and Lifestyle Intervention for Obstructive Sleep Apnoea in Adults: Rationale, Design and Methodology of the INTERAPNEA Study
title_short Interdisciplinary Weight Loss and Lifestyle Intervention for Obstructive Sleep Apnoea in Adults: Rationale, Design and Methodology of the INTERAPNEA Study
title_sort interdisciplinary weight loss and lifestyle intervention for obstructive sleep apnoea in adults: rationale, design and methodology of the interapnea study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770131/
https://www.ncbi.nlm.nih.gov/pubmed/31540168
http://dx.doi.org/10.3390/nu11092227
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