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Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System
The stilbenoids, a group of naturally occurring phenolic compounds, are found in a variety of plants, including some berries that are used as food or for medicinal purposes. They are known to be beneficial for human health as anti-inflammatory, chemopreventive, and antioxidative agents. We have inve...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770161/ https://www.ncbi.nlm.nih.gov/pubmed/31505897 http://dx.doi.org/10.3390/biom9090468 |
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author | Treml, Jakub Leláková, Veronika Šmejkal, Karel Paulíčková, Tereza Labuda, Šimon Granica, Sebastian Havlík, Jaroslav Jankovská, Dagmar Padrtová, Tereza Hošek, Jan |
author_facet | Treml, Jakub Leláková, Veronika Šmejkal, Karel Paulíčková, Tereza Labuda, Šimon Granica, Sebastian Havlík, Jaroslav Jankovská, Dagmar Padrtová, Tereza Hošek, Jan |
author_sort | Treml, Jakub |
collection | PubMed |
description | The stilbenoids, a group of naturally occurring phenolic compounds, are found in a variety of plants, including some berries that are used as food or for medicinal purposes. They are known to be beneficial for human health as anti-inflammatory, chemopreventive, and antioxidative agents. We have investigated a group of 19 stilbenoid substances in vitro using a cellular model of THP-1 macrophage-like cells and pyocyanin-induced oxidative stress to evaluate their antioxidant or pro-oxidant properties. Then we have determined any effects that they might have on the expression of the enzymes catalase, glutathione peroxidase, and heme oxygenase-1, and their effects on the activation of Nrf2. The experimental results showed that these stilbenoids could affect the formation of reactive oxygen species in a cellular model, producing either an antioxidative or pro-oxidative effect, depending on the structure pinostilbene (2) worked as a pro-oxidant and also decreased expression of catalase in the cell culture. Piceatannol (4) had shown reactive oxygen species (ROS) scavenging activity, whereas isorhapontigenin (18) had a mild direct antioxidant effect and activated Nrf2-antioxidant response element (ARE) system and elevated expression of Nrf2 and catalase. Their effects shown on cells in vitro warrant their further study in vivo. |
format | Online Article Text |
id | pubmed-6770161 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67701612019-10-30 Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System Treml, Jakub Leláková, Veronika Šmejkal, Karel Paulíčková, Tereza Labuda, Šimon Granica, Sebastian Havlík, Jaroslav Jankovská, Dagmar Padrtová, Tereza Hošek, Jan Biomolecules Article The stilbenoids, a group of naturally occurring phenolic compounds, are found in a variety of plants, including some berries that are used as food or for medicinal purposes. They are known to be beneficial for human health as anti-inflammatory, chemopreventive, and antioxidative agents. We have investigated a group of 19 stilbenoid substances in vitro using a cellular model of THP-1 macrophage-like cells and pyocyanin-induced oxidative stress to evaluate their antioxidant or pro-oxidant properties. Then we have determined any effects that they might have on the expression of the enzymes catalase, glutathione peroxidase, and heme oxygenase-1, and their effects on the activation of Nrf2. The experimental results showed that these stilbenoids could affect the formation of reactive oxygen species in a cellular model, producing either an antioxidative or pro-oxidative effect, depending on the structure pinostilbene (2) worked as a pro-oxidant and also decreased expression of catalase in the cell culture. Piceatannol (4) had shown reactive oxygen species (ROS) scavenging activity, whereas isorhapontigenin (18) had a mild direct antioxidant effect and activated Nrf2-antioxidant response element (ARE) system and elevated expression of Nrf2 and catalase. Their effects shown on cells in vitro warrant their further study in vivo. MDPI 2019-09-09 /pmc/articles/PMC6770161/ /pubmed/31505897 http://dx.doi.org/10.3390/biom9090468 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Treml, Jakub Leláková, Veronika Šmejkal, Karel Paulíčková, Tereza Labuda, Šimon Granica, Sebastian Havlík, Jaroslav Jankovská, Dagmar Padrtová, Tereza Hošek, Jan Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System |
title | Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System |
title_full | Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System |
title_fullStr | Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System |
title_full_unstemmed | Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System |
title_short | Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System |
title_sort | antioxidant activity of selected stilbenoid derivatives in a cellular model system |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770161/ https://www.ncbi.nlm.nih.gov/pubmed/31505897 http://dx.doi.org/10.3390/biom9090468 |
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