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NK Cell Hyporesponsiveness: More Is Not Always Better

Natural Killer (NK) cells are a type of cytotoxic lymphocytes that play an important role in the innate immune system. They are of particular interest for their role in elimination of intracellular pathogens, viral infection and tumor cells. As such, numerous strategies are being investigated in ord...

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Detalles Bibliográficos
Autores principales: Frutoso, Marie, Mortier, Erwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770168/
https://www.ncbi.nlm.nih.gov/pubmed/31547251
http://dx.doi.org/10.3390/ijms20184514
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author Frutoso, Marie
Mortier, Erwan
author_facet Frutoso, Marie
Mortier, Erwan
author_sort Frutoso, Marie
collection PubMed
description Natural Killer (NK) cells are a type of cytotoxic lymphocytes that play an important role in the innate immune system. They are of particular interest for their role in elimination of intracellular pathogens, viral infection and tumor cells. As such, numerous strategies are being investigated in order to potentiate their functions. One of these techniques aims at promoting the function of their activating receptors. However, different observations have revealed that providing activation signals could actually be counterproductive and lead to NK cells’ hyporesponsiveness. This phenomenon can occur during the NK cell education process, under pathological conditions, but also after treatment with different agents, including cytokines, that are promising tools to boost NK cell function. In this review, we aim to highlight the different circumstances where NK cells become hyporesponsive and the methods that could be used to restore their functionality.
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spelling pubmed-67701682019-10-30 NK Cell Hyporesponsiveness: More Is Not Always Better Frutoso, Marie Mortier, Erwan Int J Mol Sci Review Natural Killer (NK) cells are a type of cytotoxic lymphocytes that play an important role in the innate immune system. They are of particular interest for their role in elimination of intracellular pathogens, viral infection and tumor cells. As such, numerous strategies are being investigated in order to potentiate their functions. One of these techniques aims at promoting the function of their activating receptors. However, different observations have revealed that providing activation signals could actually be counterproductive and lead to NK cells’ hyporesponsiveness. This phenomenon can occur during the NK cell education process, under pathological conditions, but also after treatment with different agents, including cytokines, that are promising tools to boost NK cell function. In this review, we aim to highlight the different circumstances where NK cells become hyporesponsive and the methods that could be used to restore their functionality. MDPI 2019-09-12 /pmc/articles/PMC6770168/ /pubmed/31547251 http://dx.doi.org/10.3390/ijms20184514 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Frutoso, Marie
Mortier, Erwan
NK Cell Hyporesponsiveness: More Is Not Always Better
title NK Cell Hyporesponsiveness: More Is Not Always Better
title_full NK Cell Hyporesponsiveness: More Is Not Always Better
title_fullStr NK Cell Hyporesponsiveness: More Is Not Always Better
title_full_unstemmed NK Cell Hyporesponsiveness: More Is Not Always Better
title_short NK Cell Hyporesponsiveness: More Is Not Always Better
title_sort nk cell hyporesponsiveness: more is not always better
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770168/
https://www.ncbi.nlm.nih.gov/pubmed/31547251
http://dx.doi.org/10.3390/ijms20184514
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