Cargando…
Advances in Molecular Biology and Targeted Therapy of Mantle Cell Lymphoma
Mantle cell lymphoma (MCL) is a heterogeneous malignancy with a broad spectrum of clinical behavior from indolent to highly aggressive cases. Despite the fact that MCL remains in most cases incurable by currently applied immunochemotherapy, our increasing knowledge on the biology of MCL in the last...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770169/ https://www.ncbi.nlm.nih.gov/pubmed/31500350 http://dx.doi.org/10.3390/ijms20184417 |
_version_ | 1783455408618209280 |
---|---|
author | Klener, Pavel |
author_facet | Klener, Pavel |
author_sort | Klener, Pavel |
collection | PubMed |
description | Mantle cell lymphoma (MCL) is a heterogeneous malignancy with a broad spectrum of clinical behavior from indolent to highly aggressive cases. Despite the fact that MCL remains in most cases incurable by currently applied immunochemotherapy, our increasing knowledge on the biology of MCL in the last two decades has led to the design, testing, and approval of several innovative agents that dramatically changed the treatment landscape for MCL patients. Most importantly, the implementation of new drugs and novel treatment algorithms into clinical practice has successfully translated into improved outcomes of MCL patients not only in the clinical trials, but also in real life. This review focuses on recent advances in our understanding of the pathogenesis of MCL, and provides a brief survey of currently used treatment options with special focus on mode of action of selected innovative anti-lymphoma molecules. Finally, it outlines future perspectives of patient management with progressive shift from generally applied immunotherapy toward risk-stratified, patient-tailored protocols that would implement innovative agents and/or procedures with the ultimate goal to eradicate the lymphoma and cure the patient. |
format | Online Article Text |
id | pubmed-6770169 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67701692019-10-30 Advances in Molecular Biology and Targeted Therapy of Mantle Cell Lymphoma Klener, Pavel Int J Mol Sci Review Mantle cell lymphoma (MCL) is a heterogeneous malignancy with a broad spectrum of clinical behavior from indolent to highly aggressive cases. Despite the fact that MCL remains in most cases incurable by currently applied immunochemotherapy, our increasing knowledge on the biology of MCL in the last two decades has led to the design, testing, and approval of several innovative agents that dramatically changed the treatment landscape for MCL patients. Most importantly, the implementation of new drugs and novel treatment algorithms into clinical practice has successfully translated into improved outcomes of MCL patients not only in the clinical trials, but also in real life. This review focuses on recent advances in our understanding of the pathogenesis of MCL, and provides a brief survey of currently used treatment options with special focus on mode of action of selected innovative anti-lymphoma molecules. Finally, it outlines future perspectives of patient management with progressive shift from generally applied immunotherapy toward risk-stratified, patient-tailored protocols that would implement innovative agents and/or procedures with the ultimate goal to eradicate the lymphoma and cure the patient. MDPI 2019-09-08 /pmc/articles/PMC6770169/ /pubmed/31500350 http://dx.doi.org/10.3390/ijms20184417 Text en © 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Klener, Pavel Advances in Molecular Biology and Targeted Therapy of Mantle Cell Lymphoma |
title | Advances in Molecular Biology and Targeted Therapy of Mantle Cell Lymphoma |
title_full | Advances in Molecular Biology and Targeted Therapy of Mantle Cell Lymphoma |
title_fullStr | Advances in Molecular Biology and Targeted Therapy of Mantle Cell Lymphoma |
title_full_unstemmed | Advances in Molecular Biology and Targeted Therapy of Mantle Cell Lymphoma |
title_short | Advances in Molecular Biology and Targeted Therapy of Mantle Cell Lymphoma |
title_sort | advances in molecular biology and targeted therapy of mantle cell lymphoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770169/ https://www.ncbi.nlm.nih.gov/pubmed/31500350 http://dx.doi.org/10.3390/ijms20184417 |
work_keys_str_mv | AT klenerpavel advancesinmolecularbiologyandtargetedtherapyofmantlecelllymphoma |