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Targeting the Mitochondrial Pyruvate Carrier for Neuroprotection

The mitochondrial pyruvate carriers mediate pyruvate import into the mitochondria, which is key to the sustenance of the tricarboxylic cycle and oxidative phosphorylation. However, inhibition of mitochondria pyruvate carrier-mediated pyruvate transport was recently shown to be beneficial in experime...

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Detalles Bibliográficos
Autor principal: Tang, Bor Luen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770198/
https://www.ncbi.nlm.nih.gov/pubmed/31540439
http://dx.doi.org/10.3390/brainsci9090238
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author Tang, Bor Luen
author_facet Tang, Bor Luen
author_sort Tang, Bor Luen
collection PubMed
description The mitochondrial pyruvate carriers mediate pyruvate import into the mitochondria, which is key to the sustenance of the tricarboxylic cycle and oxidative phosphorylation. However, inhibition of mitochondria pyruvate carrier-mediated pyruvate transport was recently shown to be beneficial in experimental models of neurotoxicity pertaining to the context of Parkinson’s disease, and is also protective against excitotoxic neuronal death. These findings attested to the metabolic adaptability of neurons resulting from MPC inhibition, a phenomenon that has also been shown in other tissue types. In this short review, I discuss the mechanism and potential feasibility of mitochondrial pyruvate carrier inhibition as a neuroprotective strategy in neuronal injury and neurodegenerative diseases.
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spelling pubmed-67701982019-10-30 Targeting the Mitochondrial Pyruvate Carrier for Neuroprotection Tang, Bor Luen Brain Sci Review The mitochondrial pyruvate carriers mediate pyruvate import into the mitochondria, which is key to the sustenance of the tricarboxylic cycle and oxidative phosphorylation. However, inhibition of mitochondria pyruvate carrier-mediated pyruvate transport was recently shown to be beneficial in experimental models of neurotoxicity pertaining to the context of Parkinson’s disease, and is also protective against excitotoxic neuronal death. These findings attested to the metabolic adaptability of neurons resulting from MPC inhibition, a phenomenon that has also been shown in other tissue types. In this short review, I discuss the mechanism and potential feasibility of mitochondrial pyruvate carrier inhibition as a neuroprotective strategy in neuronal injury and neurodegenerative diseases. MDPI 2019-09-18 /pmc/articles/PMC6770198/ /pubmed/31540439 http://dx.doi.org/10.3390/brainsci9090238 Text en © 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tang, Bor Luen
Targeting the Mitochondrial Pyruvate Carrier for Neuroprotection
title Targeting the Mitochondrial Pyruvate Carrier for Neuroprotection
title_full Targeting the Mitochondrial Pyruvate Carrier for Neuroprotection
title_fullStr Targeting the Mitochondrial Pyruvate Carrier for Neuroprotection
title_full_unstemmed Targeting the Mitochondrial Pyruvate Carrier for Neuroprotection
title_short Targeting the Mitochondrial Pyruvate Carrier for Neuroprotection
title_sort targeting the mitochondrial pyruvate carrier for neuroprotection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770198/
https://www.ncbi.nlm.nih.gov/pubmed/31540439
http://dx.doi.org/10.3390/brainsci9090238
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