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Targeting the Mitochondrial Pyruvate Carrier for Neuroprotection
The mitochondrial pyruvate carriers mediate pyruvate import into the mitochondria, which is key to the sustenance of the tricarboxylic cycle and oxidative phosphorylation. However, inhibition of mitochondria pyruvate carrier-mediated pyruvate transport was recently shown to be beneficial in experime...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770198/ https://www.ncbi.nlm.nih.gov/pubmed/31540439 http://dx.doi.org/10.3390/brainsci9090238 |
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author | Tang, Bor Luen |
author_facet | Tang, Bor Luen |
author_sort | Tang, Bor Luen |
collection | PubMed |
description | The mitochondrial pyruvate carriers mediate pyruvate import into the mitochondria, which is key to the sustenance of the tricarboxylic cycle and oxidative phosphorylation. However, inhibition of mitochondria pyruvate carrier-mediated pyruvate transport was recently shown to be beneficial in experimental models of neurotoxicity pertaining to the context of Parkinson’s disease, and is also protective against excitotoxic neuronal death. These findings attested to the metabolic adaptability of neurons resulting from MPC inhibition, a phenomenon that has also been shown in other tissue types. In this short review, I discuss the mechanism and potential feasibility of mitochondrial pyruvate carrier inhibition as a neuroprotective strategy in neuronal injury and neurodegenerative diseases. |
format | Online Article Text |
id | pubmed-6770198 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67701982019-10-30 Targeting the Mitochondrial Pyruvate Carrier for Neuroprotection Tang, Bor Luen Brain Sci Review The mitochondrial pyruvate carriers mediate pyruvate import into the mitochondria, which is key to the sustenance of the tricarboxylic cycle and oxidative phosphorylation. However, inhibition of mitochondria pyruvate carrier-mediated pyruvate transport was recently shown to be beneficial in experimental models of neurotoxicity pertaining to the context of Parkinson’s disease, and is also protective against excitotoxic neuronal death. These findings attested to the metabolic adaptability of neurons resulting from MPC inhibition, a phenomenon that has also been shown in other tissue types. In this short review, I discuss the mechanism and potential feasibility of mitochondrial pyruvate carrier inhibition as a neuroprotective strategy in neuronal injury and neurodegenerative diseases. MDPI 2019-09-18 /pmc/articles/PMC6770198/ /pubmed/31540439 http://dx.doi.org/10.3390/brainsci9090238 Text en © 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tang, Bor Luen Targeting the Mitochondrial Pyruvate Carrier for Neuroprotection |
title | Targeting the Mitochondrial Pyruvate Carrier for Neuroprotection |
title_full | Targeting the Mitochondrial Pyruvate Carrier for Neuroprotection |
title_fullStr | Targeting the Mitochondrial Pyruvate Carrier for Neuroprotection |
title_full_unstemmed | Targeting the Mitochondrial Pyruvate Carrier for Neuroprotection |
title_short | Targeting the Mitochondrial Pyruvate Carrier for Neuroprotection |
title_sort | targeting the mitochondrial pyruvate carrier for neuroprotection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770198/ https://www.ncbi.nlm.nih.gov/pubmed/31540439 http://dx.doi.org/10.3390/brainsci9090238 |
work_keys_str_mv | AT tangborluen targetingthemitochondrialpyruvatecarrierforneuroprotection |