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Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas

Hearing preservation is a major goal in the treatment of neurofibromatosis type 2 (NF2) associated vestibular schwannoma (VS), particularly in children and adolescents. In this study, we retrospectively reviewed hearing and volumetry data sets of 39 operated tumors (ears) in 23 patients under the ag...

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Autores principales: Gugel, Isabel, Grimm, Florian, Liebsch, Marina, Zipfel, Julian, Teuber, Christian, Kluwe, Lan, Mautner, Victor-Felix, Tatagiba, Marcos, Schuhmann, Martin Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770212/
https://www.ncbi.nlm.nih.gov/pubmed/31527541
http://dx.doi.org/10.3390/cancers11091376
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author Gugel, Isabel
Grimm, Florian
Liebsch, Marina
Zipfel, Julian
Teuber, Christian
Kluwe, Lan
Mautner, Victor-Felix
Tatagiba, Marcos
Schuhmann, Martin Ulrich
author_facet Gugel, Isabel
Grimm, Florian
Liebsch, Marina
Zipfel, Julian
Teuber, Christian
Kluwe, Lan
Mautner, Victor-Felix
Tatagiba, Marcos
Schuhmann, Martin Ulrich
author_sort Gugel, Isabel
collection PubMed
description Hearing preservation is a major goal in the treatment of neurofibromatosis type 2 (NF2) associated vestibular schwannoma (VS), particularly in children and adolescents. In this study, we retrospectively reviewed hearing and volumetry data sets of 39 operated tumors (ears) in 23 patients under the age of 25 and in a follow-up period of 21 to 167 months. Hearing data over a compatible period on 20 other tumors, which did not receive surgery due to their less aggressive nature, were included for comparison. Surgery was carried out via a retrosigmoid approach with the brainstem auditory evoked potential (BAEP) guide. Immediately after surgery, functional hearing was maintained in 82% of ears. Average hearing scores were better in the non-surgery ears. However, the hearing scores in both groups worsened gradually with a similar dynamic during the 42-month postoperative follow-up period. No accelerated impairment of hearing was evident for the operated cases. Rather, the gap between the two hearing deterioration lines tended to close at the end of the follow-up period. Our result suggested that the BAEP-guided surgery did not cause additional hearing deterioration in the long-term and seemed to slow down hearing deterioration of those tumors that were initially more aggressive.
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spelling pubmed-67702122019-10-30 Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas Gugel, Isabel Grimm, Florian Liebsch, Marina Zipfel, Julian Teuber, Christian Kluwe, Lan Mautner, Victor-Felix Tatagiba, Marcos Schuhmann, Martin Ulrich Cancers (Basel) Article Hearing preservation is a major goal in the treatment of neurofibromatosis type 2 (NF2) associated vestibular schwannoma (VS), particularly in children and adolescents. In this study, we retrospectively reviewed hearing and volumetry data sets of 39 operated tumors (ears) in 23 patients under the age of 25 and in a follow-up period of 21 to 167 months. Hearing data over a compatible period on 20 other tumors, which did not receive surgery due to their less aggressive nature, were included for comparison. Surgery was carried out via a retrosigmoid approach with the brainstem auditory evoked potential (BAEP) guide. Immediately after surgery, functional hearing was maintained in 82% of ears. Average hearing scores were better in the non-surgery ears. However, the hearing scores in both groups worsened gradually with a similar dynamic during the 42-month postoperative follow-up period. No accelerated impairment of hearing was evident for the operated cases. Rather, the gap between the two hearing deterioration lines tended to close at the end of the follow-up period. Our result suggested that the BAEP-guided surgery did not cause additional hearing deterioration in the long-term and seemed to slow down hearing deterioration of those tumors that were initially more aggressive. MDPI 2019-09-16 /pmc/articles/PMC6770212/ /pubmed/31527541 http://dx.doi.org/10.3390/cancers11091376 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gugel, Isabel
Grimm, Florian
Liebsch, Marina
Zipfel, Julian
Teuber, Christian
Kluwe, Lan
Mautner, Victor-Felix
Tatagiba, Marcos
Schuhmann, Martin Ulrich
Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas
title Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas
title_full Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas
title_fullStr Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas
title_full_unstemmed Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas
title_short Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas
title_sort impact of surgery on long-term results of hearing in neurofibromatosis type-2 associated vestibular schwannomas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770212/
https://www.ncbi.nlm.nih.gov/pubmed/31527541
http://dx.doi.org/10.3390/cancers11091376
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