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Insights into the Secretome of Mesenchymal Stem Cells and Its Potential Applications

Mesenchymal stem cells (MSCs) have regenerative, immunoregulatory properties and can be easily isolated and expanded in vitro. Despite being a powerful tool for clinical applications, they present limitations in terms of delivery, safety, and variability of therapeutic response. Interestingly, the M...

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Detalles Bibliográficos
Autores principales: Eleuteri, Sharon, Fierabracci, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770239/
https://www.ncbi.nlm.nih.gov/pubmed/31533317
http://dx.doi.org/10.3390/ijms20184597
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author Eleuteri, Sharon
Fierabracci, Alessandra
author_facet Eleuteri, Sharon
Fierabracci, Alessandra
author_sort Eleuteri, Sharon
collection PubMed
description Mesenchymal stem cells (MSCs) have regenerative, immunoregulatory properties and can be easily isolated and expanded in vitro. Despite being a powerful tool for clinical applications, they present limitations in terms of delivery, safety, and variability of therapeutic response. Interestingly, the MSC secretome composed by cytokines, chemokines, growth factors, proteins, and extracellular vesicles, could represent a valid alternative to their use. It is noteworthy that MSC-derived extracellular vesicles (MSC-EVs) have the same effect and could be advantageous compared to the parental cells because of their specific miRNAs load. MiRNAs could be useful both in diagnostic procedures such as “liquid biopsy” to identify early pathologies and in the therapeutic field. Not only are MSC-EVs’ preservation, transfer, and production easier, but their administration is also safer, hence some clinical trials are ongoing. However, much effort is required to improve the characterization of EVs to avoid artifacts and guarantee reproducibility of the studies.
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spelling pubmed-67702392019-10-30 Insights into the Secretome of Mesenchymal Stem Cells and Its Potential Applications Eleuteri, Sharon Fierabracci, Alessandra Int J Mol Sci Review Mesenchymal stem cells (MSCs) have regenerative, immunoregulatory properties and can be easily isolated and expanded in vitro. Despite being a powerful tool for clinical applications, they present limitations in terms of delivery, safety, and variability of therapeutic response. Interestingly, the MSC secretome composed by cytokines, chemokines, growth factors, proteins, and extracellular vesicles, could represent a valid alternative to their use. It is noteworthy that MSC-derived extracellular vesicles (MSC-EVs) have the same effect and could be advantageous compared to the parental cells because of their specific miRNAs load. MiRNAs could be useful both in diagnostic procedures such as “liquid biopsy” to identify early pathologies and in the therapeutic field. Not only are MSC-EVs’ preservation, transfer, and production easier, but their administration is also safer, hence some clinical trials are ongoing. However, much effort is required to improve the characterization of EVs to avoid artifacts and guarantee reproducibility of the studies. MDPI 2019-09-17 /pmc/articles/PMC6770239/ /pubmed/31533317 http://dx.doi.org/10.3390/ijms20184597 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Eleuteri, Sharon
Fierabracci, Alessandra
Insights into the Secretome of Mesenchymal Stem Cells and Its Potential Applications
title Insights into the Secretome of Mesenchymal Stem Cells and Its Potential Applications
title_full Insights into the Secretome of Mesenchymal Stem Cells and Its Potential Applications
title_fullStr Insights into the Secretome of Mesenchymal Stem Cells and Its Potential Applications
title_full_unstemmed Insights into the Secretome of Mesenchymal Stem Cells and Its Potential Applications
title_short Insights into the Secretome of Mesenchymal Stem Cells and Its Potential Applications
title_sort insights into the secretome of mesenchymal stem cells and its potential applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770239/
https://www.ncbi.nlm.nih.gov/pubmed/31533317
http://dx.doi.org/10.3390/ijms20184597
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