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Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly
Aging is accompanied with increased frailty and comorbidities, which is potentially associated with microbiome perturbations. Dietary fibers could contribute to healthy aging by beneficially impacting gut microbiota and metabolite profiles. We aimed to compare young adults with elderly and investiga...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770243/ https://www.ncbi.nlm.nih.gov/pubmed/31547291 http://dx.doi.org/10.3390/nu11092193 |
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author | An, Ran Wilms, Ellen Smolinska, Agnieszka Hermes, Gerben D.A. Masclee, Ad A.M. de Vos, Paul Schols, Henk A. van Schooten, Frederik J. Smidt, Hauke Jonkers, Daisy M.A.E. Zoetendal, Erwin G. Troost, Freddy J. |
author_facet | An, Ran Wilms, Ellen Smolinska, Agnieszka Hermes, Gerben D.A. Masclee, Ad A.M. de Vos, Paul Schols, Henk A. van Schooten, Frederik J. Smidt, Hauke Jonkers, Daisy M.A.E. Zoetendal, Erwin G. Troost, Freddy J. |
author_sort | An, Ran |
collection | PubMed |
description | Aging is accompanied with increased frailty and comorbidities, which is potentially associated with microbiome perturbations. Dietary fibers could contribute to healthy aging by beneficially impacting gut microbiota and metabolite profiles. We aimed to compare young adults with elderly and investigate the effect of pectin supplementation on fecal microbiota composition, short chain fatty acids (SCFAs), and exhaled volatile organic compounds (VOCs) while using a randomized, double-blind, placebo-controlled parallel design. Fifty-two young adults and 48 elderly consumed 15 g/day sugar beet pectin or maltodextrin for four weeks. Fecal and exhaled breath samples were collected before and after the intervention period. Fecal samples were used for microbiota profiling by 16S rRNA gene amplicon sequencing, and for analysis of SCFAs by gas chromatography (GC). Breath was used for VOC analysis by GC-tof-MS. Young adults and elderly showed similar fecal SCFA and exhaled VOC profiles. Additionally, fecal microbiota profiles were similar, with five genera significantly different in relative abundance. Pectin supplementation did not significantly alter fecal microbiota, SCFA or exhaled VOC profiles in elderly or young adults. In conclusion, aside from some minor differences in microbial composition, healthy elderly and young adults showed comparable fecal microbiota composition and activity, which were not altered by pectin supplementation. |
format | Online Article Text |
id | pubmed-6770243 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67702432019-10-30 Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly An, Ran Wilms, Ellen Smolinska, Agnieszka Hermes, Gerben D.A. Masclee, Ad A.M. de Vos, Paul Schols, Henk A. van Schooten, Frederik J. Smidt, Hauke Jonkers, Daisy M.A.E. Zoetendal, Erwin G. Troost, Freddy J. Nutrients Article Aging is accompanied with increased frailty and comorbidities, which is potentially associated with microbiome perturbations. Dietary fibers could contribute to healthy aging by beneficially impacting gut microbiota and metabolite profiles. We aimed to compare young adults with elderly and investigate the effect of pectin supplementation on fecal microbiota composition, short chain fatty acids (SCFAs), and exhaled volatile organic compounds (VOCs) while using a randomized, double-blind, placebo-controlled parallel design. Fifty-two young adults and 48 elderly consumed 15 g/day sugar beet pectin or maltodextrin for four weeks. Fecal and exhaled breath samples were collected before and after the intervention period. Fecal samples were used for microbiota profiling by 16S rRNA gene amplicon sequencing, and for analysis of SCFAs by gas chromatography (GC). Breath was used for VOC analysis by GC-tof-MS. Young adults and elderly showed similar fecal SCFA and exhaled VOC profiles. Additionally, fecal microbiota profiles were similar, with five genera significantly different in relative abundance. Pectin supplementation did not significantly alter fecal microbiota, SCFA or exhaled VOC profiles in elderly or young adults. In conclusion, aside from some minor differences in microbial composition, healthy elderly and young adults showed comparable fecal microbiota composition and activity, which were not altered by pectin supplementation. MDPI 2019-09-12 /pmc/articles/PMC6770243/ /pubmed/31547291 http://dx.doi.org/10.3390/nu11092193 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article An, Ran Wilms, Ellen Smolinska, Agnieszka Hermes, Gerben D.A. Masclee, Ad A.M. de Vos, Paul Schols, Henk A. van Schooten, Frederik J. Smidt, Hauke Jonkers, Daisy M.A.E. Zoetendal, Erwin G. Troost, Freddy J. Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly |
title | Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly |
title_full | Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly |
title_fullStr | Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly |
title_full_unstemmed | Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly |
title_short | Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly |
title_sort | sugar beet pectin supplementation did not alter profiles of fecal microbiota and exhaled breath in healthy young adults and healthy elderly |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770243/ https://www.ncbi.nlm.nih.gov/pubmed/31547291 http://dx.doi.org/10.3390/nu11092193 |
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