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Cerebral Vascular Reactivity in Frail Older Adults with Vascular Cognitive Impairment

Background: Frailty, a state of increased vulnerability, could play a role in the progression of vascular dementia. We aim to describe the changes in cerebrovascular reactivity of older adults with frailty and vascular-type mild cognitive impairment (MCIv). Methods: This was a cross-sectional study....

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Autores principales: Aguilar-Navarro, Sara G., Mimenza-Alvarado, Alberto José, Corona-Sevilla, Isaac, Jiménez-Castillo, Gilberto A., Juárez-Cedillo, Teresa, Ávila-Funes, José Alberto, Román, Gustavo C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770260/
https://www.ncbi.nlm.nih.gov/pubmed/31450572
http://dx.doi.org/10.3390/brainsci9090214
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author Aguilar-Navarro, Sara G.
Mimenza-Alvarado, Alberto José
Corona-Sevilla, Isaac
Jiménez-Castillo, Gilberto A.
Juárez-Cedillo, Teresa
Ávila-Funes, José Alberto
Román, Gustavo C.
author_facet Aguilar-Navarro, Sara G.
Mimenza-Alvarado, Alberto José
Corona-Sevilla, Isaac
Jiménez-Castillo, Gilberto A.
Juárez-Cedillo, Teresa
Ávila-Funes, José Alberto
Román, Gustavo C.
author_sort Aguilar-Navarro, Sara G.
collection PubMed
description Background: Frailty, a state of increased vulnerability, could play a role in the progression of vascular dementia. We aim to describe the changes in cerebrovascular reactivity of older adults with frailty and vascular-type mild cognitive impairment (MCIv). Methods: This was a cross-sectional study. A comprehensive geriatric assessment, neuropsychological evaluation, and transcranial Doppler ultrasound (TCD) was performed on 180 participants who were allocated into four groups: healthy (n = 74), frail (n = 40), MCIv (n = 35), and mixed (frail + MCIv) (n = 31). ANOVA and Kruskal–Wallis tests were used for the analysis of continuous variables with and without normal distribution. Multinomial logistic regression was constructed to identify associated covariates. Results: Subjects in the mixed group, compared to healthy group, were older (75.0 ± 5.9 vs 70.3 ± 5.9 years; p < 0.001), showed lower education (9.3 ± 6.4 vs 12.2 ± 4.0 years; p = 0.054), greater frequency of diabetes (42% vs 12%; p = 0.005), worse cognitive performance (z = −0.81 ± 0.94), and reduced left medial-cerebral artery cerebrovascular reactivity (0.43 ± 0.42 cm/s). The mixed group was associated with age (odds ratio (OR) 1.16, 95% Confidence Interval (CI) = 1.06–1.27; p < 0.001), diabetes (OR 6.28, 1.81–21.84; p = 0.004), and Geriatric Depression Scale (GDS) score (OR 1.34, 95% CI = 1.09–1.67; p = 0.007). Conclusions: Frailty among older adults was associated with worse cognitive performance, diabetes, and decreased cerebral blood flow.
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spelling pubmed-67702602019-10-30 Cerebral Vascular Reactivity in Frail Older Adults with Vascular Cognitive Impairment Aguilar-Navarro, Sara G. Mimenza-Alvarado, Alberto José Corona-Sevilla, Isaac Jiménez-Castillo, Gilberto A. Juárez-Cedillo, Teresa Ávila-Funes, José Alberto Román, Gustavo C. Brain Sci Article Background: Frailty, a state of increased vulnerability, could play a role in the progression of vascular dementia. We aim to describe the changes in cerebrovascular reactivity of older adults with frailty and vascular-type mild cognitive impairment (MCIv). Methods: This was a cross-sectional study. A comprehensive geriatric assessment, neuropsychological evaluation, and transcranial Doppler ultrasound (TCD) was performed on 180 participants who were allocated into four groups: healthy (n = 74), frail (n = 40), MCIv (n = 35), and mixed (frail + MCIv) (n = 31). ANOVA and Kruskal–Wallis tests were used for the analysis of continuous variables with and without normal distribution. Multinomial logistic regression was constructed to identify associated covariates. Results: Subjects in the mixed group, compared to healthy group, were older (75.0 ± 5.9 vs 70.3 ± 5.9 years; p < 0.001), showed lower education (9.3 ± 6.4 vs 12.2 ± 4.0 years; p = 0.054), greater frequency of diabetes (42% vs 12%; p = 0.005), worse cognitive performance (z = −0.81 ± 0.94), and reduced left medial-cerebral artery cerebrovascular reactivity (0.43 ± 0.42 cm/s). The mixed group was associated with age (odds ratio (OR) 1.16, 95% Confidence Interval (CI) = 1.06–1.27; p < 0.001), diabetes (OR 6.28, 1.81–21.84; p = 0.004), and Geriatric Depression Scale (GDS) score (OR 1.34, 95% CI = 1.09–1.67; p = 0.007). Conclusions: Frailty among older adults was associated with worse cognitive performance, diabetes, and decreased cerebral blood flow. MDPI 2019-08-24 /pmc/articles/PMC6770260/ /pubmed/31450572 http://dx.doi.org/10.3390/brainsci9090214 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aguilar-Navarro, Sara G.
Mimenza-Alvarado, Alberto José
Corona-Sevilla, Isaac
Jiménez-Castillo, Gilberto A.
Juárez-Cedillo, Teresa
Ávila-Funes, José Alberto
Román, Gustavo C.
Cerebral Vascular Reactivity in Frail Older Adults with Vascular Cognitive Impairment
title Cerebral Vascular Reactivity in Frail Older Adults with Vascular Cognitive Impairment
title_full Cerebral Vascular Reactivity in Frail Older Adults with Vascular Cognitive Impairment
title_fullStr Cerebral Vascular Reactivity in Frail Older Adults with Vascular Cognitive Impairment
title_full_unstemmed Cerebral Vascular Reactivity in Frail Older Adults with Vascular Cognitive Impairment
title_short Cerebral Vascular Reactivity in Frail Older Adults with Vascular Cognitive Impairment
title_sort cerebral vascular reactivity in frail older adults with vascular cognitive impairment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770260/
https://www.ncbi.nlm.nih.gov/pubmed/31450572
http://dx.doi.org/10.3390/brainsci9090214
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