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The Epidemiology of Bloodstream Infections and Antimicrobial Susceptibility Patterns: A Nine-Year Retrospective Study at St. Dominic Hospital, Akwatia, Ghana

BACKGROUND: Bloodstream infections are among the top causes of morbidity and mortality in people of all ages, especially in immunocompromised patients in sub-Saharan Africa. This study aimed at describing the epidemiology of bloodstream infections and antimicrobial susceptibility pattern over a nine...

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Autores principales: Deku, John Gameli, Dakorah, Mavis Puopelle, Lokpo, Sylvester Yao, Orish, Verner N., Ussher, Francis Abeku, Kpene, Godsway Edem, Angmorkie Eshun, Vida, Agyei, Eunice, Attivor, Waldermer, Osei-Yeboah, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770298/
https://www.ncbi.nlm.nih.gov/pubmed/31641359
http://dx.doi.org/10.1155/2019/6750864
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author Deku, John Gameli
Dakorah, Mavis Puopelle
Lokpo, Sylvester Yao
Orish, Verner N.
Ussher, Francis Abeku
Kpene, Godsway Edem
Angmorkie Eshun, Vida
Agyei, Eunice
Attivor, Waldermer
Osei-Yeboah, James
author_facet Deku, John Gameli
Dakorah, Mavis Puopelle
Lokpo, Sylvester Yao
Orish, Verner N.
Ussher, Francis Abeku
Kpene, Godsway Edem
Angmorkie Eshun, Vida
Agyei, Eunice
Attivor, Waldermer
Osei-Yeboah, James
author_sort Deku, John Gameli
collection PubMed
description BACKGROUND: Bloodstream infections are among the top causes of morbidity and mortality in people of all ages, especially in immunocompromised patients in sub-Saharan Africa. This study aimed at describing the epidemiology of bloodstream infections and antimicrobial susceptibility pattern over a nine-year period at St. Dominic Hospital, Akwatia, in the Eastern Region of Ghana. METHOD: This study retrospectively analysed data from 4,489 patients who were referred to the Laboratory Department for blood culture and sensitivity testing from January 2009 to December 2017. Sociodemographic data included age, gender, and patients' department. Blood culture results were retrieved from archival records in the laboratory. The authorities of St. Dominic Hospital granted approval for the study. RESULTS: The incidence of bloodstream infection over the 9 years was 51.4 positive cultures per 100,000 hospital attendance. Staphylococcus aureus was the leading causative agent of bacteraemia for the first two scalar years (2009–2011 (38.9%) and 2012–2014 (42.2%)) while coagulase-negative staphylococcus (CoNS) (50.5%) was predominant for the last scalar year (2015–2017), followed by Staphylococcus aureus (169/587 (28.8%)). The highest incidence of bloodstream infections was recorded in the wet seasons (months of May (8.9 per 10,000 persons) and October (10.1 per 10,000 persons)). The bacterial isolates demonstrated high resistance to tetracyclines (390/531 (73.4%)), penicillins (1282/1669 (76.8%)), and sulphonamides (450/499 (90.2%)). CONCLUSION: Bloodstream infection and antimicrobial resistance are high in patients seeking healthcare in Akwatia. This therefore calls for concerted efforts aimed at reducing the incidence in the study area.
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spelling pubmed-67702982019-10-22 The Epidemiology of Bloodstream Infections and Antimicrobial Susceptibility Patterns: A Nine-Year Retrospective Study at St. Dominic Hospital, Akwatia, Ghana Deku, John Gameli Dakorah, Mavis Puopelle Lokpo, Sylvester Yao Orish, Verner N. Ussher, Francis Abeku Kpene, Godsway Edem Angmorkie Eshun, Vida Agyei, Eunice Attivor, Waldermer Osei-Yeboah, James J Trop Med Research Article BACKGROUND: Bloodstream infections are among the top causes of morbidity and mortality in people of all ages, especially in immunocompromised patients in sub-Saharan Africa. This study aimed at describing the epidemiology of bloodstream infections and antimicrobial susceptibility pattern over a nine-year period at St. Dominic Hospital, Akwatia, in the Eastern Region of Ghana. METHOD: This study retrospectively analysed data from 4,489 patients who were referred to the Laboratory Department for blood culture and sensitivity testing from January 2009 to December 2017. Sociodemographic data included age, gender, and patients' department. Blood culture results were retrieved from archival records in the laboratory. The authorities of St. Dominic Hospital granted approval for the study. RESULTS: The incidence of bloodstream infection over the 9 years was 51.4 positive cultures per 100,000 hospital attendance. Staphylococcus aureus was the leading causative agent of bacteraemia for the first two scalar years (2009–2011 (38.9%) and 2012–2014 (42.2%)) while coagulase-negative staphylococcus (CoNS) (50.5%) was predominant for the last scalar year (2015–2017), followed by Staphylococcus aureus (169/587 (28.8%)). The highest incidence of bloodstream infections was recorded in the wet seasons (months of May (8.9 per 10,000 persons) and October (10.1 per 10,000 persons)). The bacterial isolates demonstrated high resistance to tetracyclines (390/531 (73.4%)), penicillins (1282/1669 (76.8%)), and sulphonamides (450/499 (90.2%)). CONCLUSION: Bloodstream infection and antimicrobial resistance are high in patients seeking healthcare in Akwatia. This therefore calls for concerted efforts aimed at reducing the incidence in the study area. Hindawi 2019-09-19 /pmc/articles/PMC6770298/ /pubmed/31641359 http://dx.doi.org/10.1155/2019/6750864 Text en Copyright © 2019 John Gameli Deku et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Deku, John Gameli
Dakorah, Mavis Puopelle
Lokpo, Sylvester Yao
Orish, Verner N.
Ussher, Francis Abeku
Kpene, Godsway Edem
Angmorkie Eshun, Vida
Agyei, Eunice
Attivor, Waldermer
Osei-Yeboah, James
The Epidemiology of Bloodstream Infections and Antimicrobial Susceptibility Patterns: A Nine-Year Retrospective Study at St. Dominic Hospital, Akwatia, Ghana
title The Epidemiology of Bloodstream Infections and Antimicrobial Susceptibility Patterns: A Nine-Year Retrospective Study at St. Dominic Hospital, Akwatia, Ghana
title_full The Epidemiology of Bloodstream Infections and Antimicrobial Susceptibility Patterns: A Nine-Year Retrospective Study at St. Dominic Hospital, Akwatia, Ghana
title_fullStr The Epidemiology of Bloodstream Infections and Antimicrobial Susceptibility Patterns: A Nine-Year Retrospective Study at St. Dominic Hospital, Akwatia, Ghana
title_full_unstemmed The Epidemiology of Bloodstream Infections and Antimicrobial Susceptibility Patterns: A Nine-Year Retrospective Study at St. Dominic Hospital, Akwatia, Ghana
title_short The Epidemiology of Bloodstream Infections and Antimicrobial Susceptibility Patterns: A Nine-Year Retrospective Study at St. Dominic Hospital, Akwatia, Ghana
title_sort epidemiology of bloodstream infections and antimicrobial susceptibility patterns: a nine-year retrospective study at st. dominic hospital, akwatia, ghana
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770298/
https://www.ncbi.nlm.nih.gov/pubmed/31641359
http://dx.doi.org/10.1155/2019/6750864
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