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Chinese Herbal Medicine Ganoderma tsugae Displays Potential Anti-Cancer Efficacy on Metastatic Prostate Cancer Cells
Resistance to the current therapies is the main clinical challenge in the treatment of lethal metastatic prostate cancer (mPCa). Developing novel therapeutic approaches with effective regimes and minimal side effects for this fatal disease remain a priority in prostate cancer study. In the present s...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770323/ https://www.ncbi.nlm.nih.gov/pubmed/31500366 http://dx.doi.org/10.3390/ijms20184418 |
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author | Huang, Wen-Chin Chang, Meng-Shiun Huang, Shih-Yin Tsai, Ching-Ju Kuo, Pin-Hung Chang, Han-Wen Huang, Sheng-Teng Kuo, Chao-Lin Lee, Shou-Lun Kao, Ming-Ching |
author_facet | Huang, Wen-Chin Chang, Meng-Shiun Huang, Shih-Yin Tsai, Ching-Ju Kuo, Pin-Hung Chang, Han-Wen Huang, Sheng-Teng Kuo, Chao-Lin Lee, Shou-Lun Kao, Ming-Ching |
author_sort | Huang, Wen-Chin |
collection | PubMed |
description | Resistance to the current therapies is the main clinical challenge in the treatment of lethal metastatic prostate cancer (mPCa). Developing novel therapeutic approaches with effective regimes and minimal side effects for this fatal disease remain a priority in prostate cancer study. In the present study, we demonstrated that a traditional Chinese medicine, quality-assured Ganoderma tsugae ethanol extract (GTEE), significantly suppressed cell growth and metastatic capability and caused cell cycle arrest through decreasing expression of cyclins in mPCa cells, PC-3 and DU145 cells. GTEE also induced caspase-dependent apoptosis in mPCa cells. We further showed the potent therapeutic efficacy of GTEE by inhibiting subcutaneous PC-3 tumor growth in a xenograft model. The in vitro and in vivo efficacies on mPCa cells were due to blockade of the PI3K/Akt and MAPK/ERK signaling pathways associated with cancer cell growth, survival and apoptosis. These preclinical data provide the molecular basis for a new potential therapeutic approach toward the treatment of lethal prostate cancer progression. |
format | Online Article Text |
id | pubmed-6770323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67703232019-10-30 Chinese Herbal Medicine Ganoderma tsugae Displays Potential Anti-Cancer Efficacy on Metastatic Prostate Cancer Cells Huang, Wen-Chin Chang, Meng-Shiun Huang, Shih-Yin Tsai, Ching-Ju Kuo, Pin-Hung Chang, Han-Wen Huang, Sheng-Teng Kuo, Chao-Lin Lee, Shou-Lun Kao, Ming-Ching Int J Mol Sci Article Resistance to the current therapies is the main clinical challenge in the treatment of lethal metastatic prostate cancer (mPCa). Developing novel therapeutic approaches with effective regimes and minimal side effects for this fatal disease remain a priority in prostate cancer study. In the present study, we demonstrated that a traditional Chinese medicine, quality-assured Ganoderma tsugae ethanol extract (GTEE), significantly suppressed cell growth and metastatic capability and caused cell cycle arrest through decreasing expression of cyclins in mPCa cells, PC-3 and DU145 cells. GTEE also induced caspase-dependent apoptosis in mPCa cells. We further showed the potent therapeutic efficacy of GTEE by inhibiting subcutaneous PC-3 tumor growth in a xenograft model. The in vitro and in vivo efficacies on mPCa cells were due to blockade of the PI3K/Akt and MAPK/ERK signaling pathways associated with cancer cell growth, survival and apoptosis. These preclinical data provide the molecular basis for a new potential therapeutic approach toward the treatment of lethal prostate cancer progression. MDPI 2019-09-08 /pmc/articles/PMC6770323/ /pubmed/31500366 http://dx.doi.org/10.3390/ijms20184418 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Huang, Wen-Chin Chang, Meng-Shiun Huang, Shih-Yin Tsai, Ching-Ju Kuo, Pin-Hung Chang, Han-Wen Huang, Sheng-Teng Kuo, Chao-Lin Lee, Shou-Lun Kao, Ming-Ching Chinese Herbal Medicine Ganoderma tsugae Displays Potential Anti-Cancer Efficacy on Metastatic Prostate Cancer Cells |
title | Chinese Herbal Medicine Ganoderma tsugae Displays Potential Anti-Cancer Efficacy on Metastatic Prostate Cancer Cells |
title_full | Chinese Herbal Medicine Ganoderma tsugae Displays Potential Anti-Cancer Efficacy on Metastatic Prostate Cancer Cells |
title_fullStr | Chinese Herbal Medicine Ganoderma tsugae Displays Potential Anti-Cancer Efficacy on Metastatic Prostate Cancer Cells |
title_full_unstemmed | Chinese Herbal Medicine Ganoderma tsugae Displays Potential Anti-Cancer Efficacy on Metastatic Prostate Cancer Cells |
title_short | Chinese Herbal Medicine Ganoderma tsugae Displays Potential Anti-Cancer Efficacy on Metastatic Prostate Cancer Cells |
title_sort | chinese herbal medicine ganoderma tsugae displays potential anti-cancer efficacy on metastatic prostate cancer cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770323/ https://www.ncbi.nlm.nih.gov/pubmed/31500366 http://dx.doi.org/10.3390/ijms20184418 |
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