Targeting Autophagy by MPT0L145, a Highly Potent PIK3C3 Inhibitor, Provides Synergistic Interaction to Targeted or Chemotherapeutic Agents in Cancer Cells

Anticancer therapies reportedly promote pro-survival autophagy in cancer cells that confers drug resistance, rationalizing the concept to combine autophagy inhibitors to increase their therapeutic potential. We previously identified that MPT0L145 is a PIK3C3/FGFR inhibitor that not only increases au...

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Detalles Bibliográficos
Autores principales: Chen, Chun-Han, Hsieh, Tsung-Han, Lin, Yu-Chen, Liu, Yun-Ru, Liou, Jing-Ping, Yen, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770340/
https://www.ncbi.nlm.nih.gov/pubmed/31514441
http://dx.doi.org/10.3390/cancers11091345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770340/
https://www.ncbi.nlm.nih.gov/pubmed/31514441
http://dx.doi.org/10.3390/cancers11091345

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