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Anti-Inflammatory and Antinociceptive Activity of Pollen Extract Collected by Stingless Bee Melipona fasciculata
The stingless bee, Melipona fasciculata Smith (Apidae, Meliponini), is a native species from Brazil. Their products have high biotechnological potential, however there are no studies about the biological activities of pollen collected by M. fasciculata. In this context, the present study investigate...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770349/ https://www.ncbi.nlm.nih.gov/pubmed/31547230 http://dx.doi.org/10.3390/ijms20184512 |
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author | Lopes, Alberto Jorge Oliveira Vasconcelos, Cleydlenne Costa Pereira, Francisco Assis Nascimento Silva, Rosa Helena Moraes Queiroz, Pedro Felipe dos Santos Fernandes, Caio Viana Garcia, João Batista Santos Ramos, Ricardo Martins da Rocha, Cláudia Quintino Lima, Silvia Tereza de Jesus Rodrigues Moreira Cartágenes, Maria do Socorro de Sousa Ribeiro, Maria Nilce de Sousa |
author_facet | Lopes, Alberto Jorge Oliveira Vasconcelos, Cleydlenne Costa Pereira, Francisco Assis Nascimento Silva, Rosa Helena Moraes Queiroz, Pedro Felipe dos Santos Fernandes, Caio Viana Garcia, João Batista Santos Ramos, Ricardo Martins da Rocha, Cláudia Quintino Lima, Silvia Tereza de Jesus Rodrigues Moreira Cartágenes, Maria do Socorro de Sousa Ribeiro, Maria Nilce de Sousa |
author_sort | Lopes, Alberto Jorge Oliveira |
collection | PubMed |
description | The stingless bee, Melipona fasciculata Smith (Apidae, Meliponini), is a native species from Brazil. Their products have high biotechnological potential, however there are no studies about the biological activities of pollen collected by M. fasciculata. In this context, the present study investigated the chemical composition, anti-oxidant, anti-inflammatory, and analgesic activities of hydroethanolic pollen extracts collected by M. fasciculata in three cities in Maranhão State, Brazil. We verified the antioxidant activity of the extracts and inhibitory activity against the cyclooxygenase enzyme using in vitro assays and in allowed to select the extract with higher efficiency to be used on in vivo assays. In these trials, the selected extract showed high anti-inflammatory activity as well as nociceptive effects at central and peripheral level, suggesting that this extract acts on inhibition of histamine release and decreased synthesis of prostaglandins and the in-silico study suggested that polyphenols and acids fatty acids in the extract may be associated with these activities. The results of the present study report the high biological potential of pollen extract and we conclude that the pollen collected by M. fasciculata can be considered as the object of research for new pharmacological alternatives. |
format | Online Article Text |
id | pubmed-6770349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67703492019-10-30 Anti-Inflammatory and Antinociceptive Activity of Pollen Extract Collected by Stingless Bee Melipona fasciculata Lopes, Alberto Jorge Oliveira Vasconcelos, Cleydlenne Costa Pereira, Francisco Assis Nascimento Silva, Rosa Helena Moraes Queiroz, Pedro Felipe dos Santos Fernandes, Caio Viana Garcia, João Batista Santos Ramos, Ricardo Martins da Rocha, Cláudia Quintino Lima, Silvia Tereza de Jesus Rodrigues Moreira Cartágenes, Maria do Socorro de Sousa Ribeiro, Maria Nilce de Sousa Int J Mol Sci Article The stingless bee, Melipona fasciculata Smith (Apidae, Meliponini), is a native species from Brazil. Their products have high biotechnological potential, however there are no studies about the biological activities of pollen collected by M. fasciculata. In this context, the present study investigated the chemical composition, anti-oxidant, anti-inflammatory, and analgesic activities of hydroethanolic pollen extracts collected by M. fasciculata in three cities in Maranhão State, Brazil. We verified the antioxidant activity of the extracts and inhibitory activity against the cyclooxygenase enzyme using in vitro assays and in allowed to select the extract with higher efficiency to be used on in vivo assays. In these trials, the selected extract showed high anti-inflammatory activity as well as nociceptive effects at central and peripheral level, suggesting that this extract acts on inhibition of histamine release and decreased synthesis of prostaglandins and the in-silico study suggested that polyphenols and acids fatty acids in the extract may be associated with these activities. The results of the present study report the high biological potential of pollen extract and we conclude that the pollen collected by M. fasciculata can be considered as the object of research for new pharmacological alternatives. MDPI 2019-09-12 /pmc/articles/PMC6770349/ /pubmed/31547230 http://dx.doi.org/10.3390/ijms20184512 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lopes, Alberto Jorge Oliveira Vasconcelos, Cleydlenne Costa Pereira, Francisco Assis Nascimento Silva, Rosa Helena Moraes Queiroz, Pedro Felipe dos Santos Fernandes, Caio Viana Garcia, João Batista Santos Ramos, Ricardo Martins da Rocha, Cláudia Quintino Lima, Silvia Tereza de Jesus Rodrigues Moreira Cartágenes, Maria do Socorro de Sousa Ribeiro, Maria Nilce de Sousa Anti-Inflammatory and Antinociceptive Activity of Pollen Extract Collected by Stingless Bee Melipona fasciculata |
title | Anti-Inflammatory and Antinociceptive Activity of Pollen Extract Collected by Stingless Bee Melipona fasciculata |
title_full | Anti-Inflammatory and Antinociceptive Activity of Pollen Extract Collected by Stingless Bee Melipona fasciculata |
title_fullStr | Anti-Inflammatory and Antinociceptive Activity of Pollen Extract Collected by Stingless Bee Melipona fasciculata |
title_full_unstemmed | Anti-Inflammatory and Antinociceptive Activity of Pollen Extract Collected by Stingless Bee Melipona fasciculata |
title_short | Anti-Inflammatory and Antinociceptive Activity of Pollen Extract Collected by Stingless Bee Melipona fasciculata |
title_sort | anti-inflammatory and antinociceptive activity of pollen extract collected by stingless bee melipona fasciculata |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770349/ https://www.ncbi.nlm.nih.gov/pubmed/31547230 http://dx.doi.org/10.3390/ijms20184512 |
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