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Ultra-Mutation in IDH Wild-Type Glioblastomas of Patients Younger than 55 Years is Associated with Defective Mismatch Repair, Microsatellite Instability, and Giant Cell Enrichment

Background: Glioblastomas (GBMs) are classified into isocitrate dehydrogenase (IDH) mutants and IDH wild-types (IDH-wt). This study aimed at identifying the mutational assets of IDH-wt GBMs in patients aged 18–54 years for which limited data are available. Methods: Sixteen IDH-wt GBMs from adults &l...

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Detalles Bibliográficos
Autores principales:	Barresi, Valeria, Simbolo, Michele, Mafficini, Andrea, Piredda, Maria Liliana, Caffo, Maria, Cardali, Salvatore Massimiliano, Germanò, Antonino, Cingarlini, Sara, Ghimenton, Claudio, Scarpa, Aldo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770353/ https://www.ncbi.nlm.nih.gov/pubmed/31480372 http://dx.doi.org/10.3390/cancers11091279

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