Novel Locus Associated with Symmetrical Lupoid Onychodystrophy in the Bearded Collie

Symmetrical lupoid onychodystrophy (SLO) is characterized by inflammation of the nail bed and nail sloughing that causes affected dogs considerable pain. Disease etiology remains unclear, although an autoimmune component is suspected. A genome-wide association study on Bearded Collies revealed regio...

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Autores principales: Gershony, Liza C., Belanger, Janelle M., Hytönen, Marjo K., Lohi, Hannes, Oberbauer, Anita M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770358/
https://www.ncbi.nlm.nih.gov/pubmed/31443497
http://dx.doi.org/10.3390/genes10090635
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author Gershony, Liza C.
Belanger, Janelle M.
Hytönen, Marjo K.
Lohi, Hannes
Oberbauer, Anita M.
author_facet Gershony, Liza C.
Belanger, Janelle M.
Hytönen, Marjo K.
Lohi, Hannes
Oberbauer, Anita M.
author_sort Gershony, Liza C.
collection PubMed
description Symmetrical lupoid onychodystrophy (SLO) is characterized by inflammation of the nail bed and nail sloughing that causes affected dogs considerable pain. Disease etiology remains unclear, although an autoimmune component is suspected. A genome-wide association study on Bearded Collies revealed regions of association on canine chromosomes (CFA) 12 and 17. The large region of association on CFA12 likely consists of two smaller linked regions, both of which are also linked to the dog leukocyte antigen (DLA) class II genes. Dogs homozygous for the alternate allele at the top CFA12 SNP also carried two DLA class II risk haplotypes for SLO, and this locus explained most of the increased risk for disease seen throughout the CFA12 region of association. A stronger peak was seen on CFA17 when analysis was done solely on dogs that carried DLA class II risk haplotypes for SLO. The majority of SLO dogs carried a homozygous alternate genotype on CFA12 and at least one CFA17 risk haplotype. Our findings offer progress toward uncovering the genetic basis of SLO. While the contribution of the CFA17 region remains unclear, both CFA12 and CFA17 regions are significantly associated with SLO disease expression in the Bearded Collie and contain potential candidate genes for this disease.
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spelling pubmed-67703582019-10-30 Novel Locus Associated with Symmetrical Lupoid Onychodystrophy in the Bearded Collie Gershony, Liza C. Belanger, Janelle M. Hytönen, Marjo K. Lohi, Hannes Oberbauer, Anita M. Genes (Basel) Article Symmetrical lupoid onychodystrophy (SLO) is characterized by inflammation of the nail bed and nail sloughing that causes affected dogs considerable pain. Disease etiology remains unclear, although an autoimmune component is suspected. A genome-wide association study on Bearded Collies revealed regions of association on canine chromosomes (CFA) 12 and 17. The large region of association on CFA12 likely consists of two smaller linked regions, both of which are also linked to the dog leukocyte antigen (DLA) class II genes. Dogs homozygous for the alternate allele at the top CFA12 SNP also carried two DLA class II risk haplotypes for SLO, and this locus explained most of the increased risk for disease seen throughout the CFA12 region of association. A stronger peak was seen on CFA17 when analysis was done solely on dogs that carried DLA class II risk haplotypes for SLO. The majority of SLO dogs carried a homozygous alternate genotype on CFA12 and at least one CFA17 risk haplotype. Our findings offer progress toward uncovering the genetic basis of SLO. While the contribution of the CFA17 region remains unclear, both CFA12 and CFA17 regions are significantly associated with SLO disease expression in the Bearded Collie and contain potential candidate genes for this disease. MDPI 2019-08-22 /pmc/articles/PMC6770358/ /pubmed/31443497 http://dx.doi.org/10.3390/genes10090635 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gershony, Liza C.
Belanger, Janelle M.
Hytönen, Marjo K.
Lohi, Hannes
Oberbauer, Anita M.
Novel Locus Associated with Symmetrical Lupoid Onychodystrophy in the Bearded Collie
title Novel Locus Associated with Symmetrical Lupoid Onychodystrophy in the Bearded Collie
title_full Novel Locus Associated with Symmetrical Lupoid Onychodystrophy in the Bearded Collie
title_fullStr Novel Locus Associated with Symmetrical Lupoid Onychodystrophy in the Bearded Collie
title_full_unstemmed Novel Locus Associated with Symmetrical Lupoid Onychodystrophy in the Bearded Collie
title_short Novel Locus Associated with Symmetrical Lupoid Onychodystrophy in the Bearded Collie
title_sort novel locus associated with symmetrical lupoid onychodystrophy in the bearded collie
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770358/
https://www.ncbi.nlm.nih.gov/pubmed/31443497
http://dx.doi.org/10.3390/genes10090635
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