Cargando…

Using an Overlapping Time Interval Strategy to Study Diagnostic Instability in Mild Cognitive Impairment Subtypes

(1) Background: Mild cognitive impairment (MCI) is a diagnostic label in which stability is typically low. The aim of this study was to examine temporal changes in the diagnosis of MCI subtypes by using an overlapping-time strategy; (2) Methods: The study included 435 participants aged over 50 years...

Descripción completa

Detalles Bibliográficos
Autores principales: Facal, David, Guàrdia-Olmos, Joan, Pereiro, Arturo X., Lojo-Seoane, Cristina, Peró, Maribel, Juncos-Rabadán, Onésimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770378/
https://www.ncbi.nlm.nih.gov/pubmed/31546979
http://dx.doi.org/10.3390/brainsci9090242
_version_ 1783455458355314688
author Facal, David
Guàrdia-Olmos, Joan
Pereiro, Arturo X.
Lojo-Seoane, Cristina
Peró, Maribel
Juncos-Rabadán, Onésimo
author_facet Facal, David
Guàrdia-Olmos, Joan
Pereiro, Arturo X.
Lojo-Seoane, Cristina
Peró, Maribel
Juncos-Rabadán, Onésimo
author_sort Facal, David
collection PubMed
description (1) Background: Mild cognitive impairment (MCI) is a diagnostic label in which stability is typically low. The aim of this study was to examine temporal changes in the diagnosis of MCI subtypes by using an overlapping-time strategy; (2) Methods: The study included 435 participants aged over 50 years with subjective cognitive complaints and who completed at least one follow-up evaluation. The probability of transition was estimated using Bayesian odds ratios; (3) Results: Within the different time intervals, the controls with subjective cognitive complaints represented the largest proportion of participants, followed by sda-MCI at baseline and in the first five intervals of the follow-up, but not in the last eight intervals. The odds ratios indicated higher odds of conversion to dementia in sda-MCI and mda-MCI groups relative to na-MCI (e.g., interval 9–15 months—sda-MCI OR = 9 and mda-MCI OR = 3.36; interval 27–33—sda-MCI OR = 16 and mda-MCI = 5.06; interval 42–48—sda-MCI OR = 8.16 and mda-MCI = 3.45; interval 45–51—sda-MCI OR = 3.31 and mda-MCI = 1); (4) Conclusions: Notable patterns of instability consistent with the current literature were observed. The limitations of a prospective approach in the study of MCI transitions are discussed.
format Online
Article
Text
id pubmed-6770378
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-67703782019-10-30 Using an Overlapping Time Interval Strategy to Study Diagnostic Instability in Mild Cognitive Impairment Subtypes Facal, David Guàrdia-Olmos, Joan Pereiro, Arturo X. Lojo-Seoane, Cristina Peró, Maribel Juncos-Rabadán, Onésimo Brain Sci Article (1) Background: Mild cognitive impairment (MCI) is a diagnostic label in which stability is typically low. The aim of this study was to examine temporal changes in the diagnosis of MCI subtypes by using an overlapping-time strategy; (2) Methods: The study included 435 participants aged over 50 years with subjective cognitive complaints and who completed at least one follow-up evaluation. The probability of transition was estimated using Bayesian odds ratios; (3) Results: Within the different time intervals, the controls with subjective cognitive complaints represented the largest proportion of participants, followed by sda-MCI at baseline and in the first five intervals of the follow-up, but not in the last eight intervals. The odds ratios indicated higher odds of conversion to dementia in sda-MCI and mda-MCI groups relative to na-MCI (e.g., interval 9–15 months—sda-MCI OR = 9 and mda-MCI OR = 3.36; interval 27–33—sda-MCI OR = 16 and mda-MCI = 5.06; interval 42–48—sda-MCI OR = 8.16 and mda-MCI = 3.45; interval 45–51—sda-MCI OR = 3.31 and mda-MCI = 1); (4) Conclusions: Notable patterns of instability consistent with the current literature were observed. The limitations of a prospective approach in the study of MCI transitions are discussed. MDPI 2019-09-19 /pmc/articles/PMC6770378/ /pubmed/31546979 http://dx.doi.org/10.3390/brainsci9090242 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Facal, David
Guàrdia-Olmos, Joan
Pereiro, Arturo X.
Lojo-Seoane, Cristina
Peró, Maribel
Juncos-Rabadán, Onésimo
Using an Overlapping Time Interval Strategy to Study Diagnostic Instability in Mild Cognitive Impairment Subtypes
title Using an Overlapping Time Interval Strategy to Study Diagnostic Instability in Mild Cognitive Impairment Subtypes
title_full Using an Overlapping Time Interval Strategy to Study Diagnostic Instability in Mild Cognitive Impairment Subtypes
title_fullStr Using an Overlapping Time Interval Strategy to Study Diagnostic Instability in Mild Cognitive Impairment Subtypes
title_full_unstemmed Using an Overlapping Time Interval Strategy to Study Diagnostic Instability in Mild Cognitive Impairment Subtypes
title_short Using an Overlapping Time Interval Strategy to Study Diagnostic Instability in Mild Cognitive Impairment Subtypes
title_sort using an overlapping time interval strategy to study diagnostic instability in mild cognitive impairment subtypes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770378/
https://www.ncbi.nlm.nih.gov/pubmed/31546979
http://dx.doi.org/10.3390/brainsci9090242
work_keys_str_mv AT facaldavid usinganoverlappingtimeintervalstrategytostudydiagnosticinstabilityinmildcognitiveimpairmentsubtypes
AT guardiaolmosjoan usinganoverlappingtimeintervalstrategytostudydiagnosticinstabilityinmildcognitiveimpairmentsubtypes
AT pereiroarturox usinganoverlappingtimeintervalstrategytostudydiagnosticinstabilityinmildcognitiveimpairmentsubtypes
AT lojoseoanecristina usinganoverlappingtimeintervalstrategytostudydiagnosticinstabilityinmildcognitiveimpairmentsubtypes
AT peromaribel usinganoverlappingtimeintervalstrategytostudydiagnosticinstabilityinmildcognitiveimpairmentsubtypes
AT juncosrabadanonesimo usinganoverlappingtimeintervalstrategytostudydiagnosticinstabilityinmildcognitiveimpairmentsubtypes