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Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance

Glioblastoma (GBM) is the most common and aggressive primary brain tumor and is nearly universally fatal. Targeted therapy and immunotherapy have had limited success in GBM, leaving surgery, alkylating chemotherapy and ionizing radiation as the standards of care. Like most cancers, GBMs rewire metab...

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Detalles Bibliográficos
Autores principales: Zhou, Weihua, Wahl, Daniel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770393/
https://www.ncbi.nlm.nih.gov/pubmed/31450721
http://dx.doi.org/10.3390/cancers11091231
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author Zhou, Weihua
Wahl, Daniel R.
author_facet Zhou, Weihua
Wahl, Daniel R.
author_sort Zhou, Weihua
collection PubMed
description Glioblastoma (GBM) is the most common and aggressive primary brain tumor and is nearly universally fatal. Targeted therapy and immunotherapy have had limited success in GBM, leaving surgery, alkylating chemotherapy and ionizing radiation as the standards of care. Like most cancers, GBMs rewire metabolism to fuel survival, proliferation, and invasion. Emerging evidence suggests that this metabolic reprogramming also mediates resistance to the standard-of-care therapies used to treat GBM. In this review, we discuss the noteworthy metabolic features of GBM, the key pathways that reshape tumor metabolism, and how inhibiting abnormal metabolism may be able to overcome the inherent resistance of GBM to radiation and chemotherapy.
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spelling pubmed-67703932019-10-30 Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance Zhou, Weihua Wahl, Daniel R. Cancers (Basel) Review Glioblastoma (GBM) is the most common and aggressive primary brain tumor and is nearly universally fatal. Targeted therapy and immunotherapy have had limited success in GBM, leaving surgery, alkylating chemotherapy and ionizing radiation as the standards of care. Like most cancers, GBMs rewire metabolism to fuel survival, proliferation, and invasion. Emerging evidence suggests that this metabolic reprogramming also mediates resistance to the standard-of-care therapies used to treat GBM. In this review, we discuss the noteworthy metabolic features of GBM, the key pathways that reshape tumor metabolism, and how inhibiting abnormal metabolism may be able to overcome the inherent resistance of GBM to radiation and chemotherapy. MDPI 2019-08-23 /pmc/articles/PMC6770393/ /pubmed/31450721 http://dx.doi.org/10.3390/cancers11091231 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhou, Weihua
Wahl, Daniel R.
Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance
title Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance
title_full Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance
title_fullStr Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance
title_full_unstemmed Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance
title_short Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance
title_sort metabolic abnormalities in glioblastoma and metabolic strategies to overcome treatment resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770393/
https://www.ncbi.nlm.nih.gov/pubmed/31450721
http://dx.doi.org/10.3390/cancers11091231
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