Second Generation mTOR Inhibitors as a Double-Edged Sword in Malignant Glioma Treatment

Glioblastomas (GBs) frequently display activation of the epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR). mTOR exists as part of two multiprotein complexes, mTOR complex 1 (mTORC1) and 2 (mTORC2). In GBs, mTORC1 inhibitors such as rapamycin have performed poorly in c...

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Detalles Bibliográficos
Autores principales: Heinzen, Dennis, Divé, Iris, Lorenz, Nadja I., Luger, Anna-Luisa, Steinbach, Joachim P., Ronellenfitsch, Michael W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770420/
https://www.ncbi.nlm.nih.gov/pubmed/31510109
http://dx.doi.org/10.3390/ijms20184474

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