Reparative and Regenerative Effects of Mesenchymal Stromal Cells—Promising Potential for Kidney Transplantation?

Mesenchymal stromal cells (MSCs) possess reparative, regenerative and immunomodulatory properties. The current literature suggests that MSCs could improve kidney transplant outcome via immunomodulation. In many clinical domains, research has also focussed on the regenerative and reparative effects o...

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Detalles Bibliográficos
Autores principales: Pool, Merel, Leuvenink, Henri, Moers, Cyril
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770554/
https://www.ncbi.nlm.nih.gov/pubmed/31540361
http://dx.doi.org/10.3390/ijms20184614
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author Pool, Merel
Leuvenink, Henri
Moers, Cyril
author_facet Pool, Merel
Leuvenink, Henri
Moers, Cyril
author_sort Pool, Merel
collection PubMed
description Mesenchymal stromal cells (MSCs) possess reparative, regenerative and immunomodulatory properties. The current literature suggests that MSCs could improve kidney transplant outcome via immunomodulation. In many clinical domains, research has also focussed on the regenerative and reparative effects of therapies with MSCs. However, in the field of transplantation, data on this subject remain scarce. This review provides an overview of what is known about the regenerative and reparative effects of MSCs in various fields ranging from wound care to fracture healing and also examines the potential of these promising MSC properties to improve the outcome of kidney transplantations.
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spelling pubmed-67705542019-10-30 Reparative and Regenerative Effects of Mesenchymal Stromal Cells—Promising Potential for Kidney Transplantation? Pool, Merel Leuvenink, Henri Moers, Cyril Int J Mol Sci Review Mesenchymal stromal cells (MSCs) possess reparative, regenerative and immunomodulatory properties. The current literature suggests that MSCs could improve kidney transplant outcome via immunomodulation. In many clinical domains, research has also focussed on the regenerative and reparative effects of therapies with MSCs. However, in the field of transplantation, data on this subject remain scarce. This review provides an overview of what is known about the regenerative and reparative effects of MSCs in various fields ranging from wound care to fracture healing and also examines the potential of these promising MSC properties to improve the outcome of kidney transplantations. MDPI 2019-09-18 /pmc/articles/PMC6770554/ /pubmed/31540361 http://dx.doi.org/10.3390/ijms20184614 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pool, Merel
Leuvenink, Henri
Moers, Cyril
Reparative and Regenerative Effects of Mesenchymal Stromal Cells—Promising Potential for Kidney Transplantation?
title Reparative and Regenerative Effects of Mesenchymal Stromal Cells—Promising Potential for Kidney Transplantation?
title_full Reparative and Regenerative Effects of Mesenchymal Stromal Cells—Promising Potential for Kidney Transplantation?
title_fullStr Reparative and Regenerative Effects of Mesenchymal Stromal Cells—Promising Potential for Kidney Transplantation?
title_full_unstemmed Reparative and Regenerative Effects of Mesenchymal Stromal Cells—Promising Potential for Kidney Transplantation?
title_short Reparative and Regenerative Effects of Mesenchymal Stromal Cells—Promising Potential for Kidney Transplantation?
title_sort reparative and regenerative effects of mesenchymal stromal cells—promising potential for kidney transplantation?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770554/
https://www.ncbi.nlm.nih.gov/pubmed/31540361
http://dx.doi.org/10.3390/ijms20184614
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