Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer

Reprogrammed glucose metabolism is one of the hallmarks of cancer, and increased expression of key glycolytic enzymes, such as pyruvate kinase M2 (PKM2) and lactate dehydrogenase A (LDHA), has been associated with poor prognosis in various malignancies. Targeting these enzymes could attenuate aerobi...

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Detalles Bibliográficos
Autores principales: Mohammad, Goran Hamid, Vassileva, Vessela, Acedo, Pilar, Olde Damink, Steven W. M., Malago, Massimo, Dhar, Dipok Kumar, Pereira, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770573/
https://www.ncbi.nlm.nih.gov/pubmed/31527446
http://dx.doi.org/10.3390/cancers11091372

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