New Thalidomide-Resembling Dicarboximides Target ABC50 Protein and Show Antileukemic and Immunomodulatory Activities

We identified novel dicarboximides that were selectively cytotoxic towards human leukemia cells. Using chemical and biological methods, we characterized the biological activity, identified cellular protein targets and defined the mechanism of action of the test dicarboximides. The reported IC(50) va...

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Detalles Bibliográficos
Autores principales: Cieślak, Marcin, Kaźmierczak-Barańska, Julia, Królewska-Golińska, Karolina, Napiórkowska, Mariola, Stukan, Iga, Wojda, Urszula, Nawrot, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770581/
https://www.ncbi.nlm.nih.gov/pubmed/31487824
http://dx.doi.org/10.3390/biom9090446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770581/
https://www.ncbi.nlm.nih.gov/pubmed/31487824
http://dx.doi.org/10.3390/biom9090446

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