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Noncanonical Ion Channel Behaviour in Pain

Ion channels contribute fundamental properties to cell membranes. Although highly diverse in conductivity, structure, location, and function, many of them can be regulated by common mechanisms, such as voltage or (de-)phosphorylation. Primarily considering ion channels involved in the nociceptive sy...

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Autores principales: Ciotu, Cosmin I., Tsantoulas, Christoforos, Meents, Jannis, Lampert, Angelika, McMahon, Stephen B., Ludwig, Andreas, Fischer, Michael J.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770626/
https://www.ncbi.nlm.nih.gov/pubmed/31540178
http://dx.doi.org/10.3390/ijms20184572
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author Ciotu, Cosmin I.
Tsantoulas, Christoforos
Meents, Jannis
Lampert, Angelika
McMahon, Stephen B.
Ludwig, Andreas
Fischer, Michael J.M.
author_facet Ciotu, Cosmin I.
Tsantoulas, Christoforos
Meents, Jannis
Lampert, Angelika
McMahon, Stephen B.
Ludwig, Andreas
Fischer, Michael J.M.
author_sort Ciotu, Cosmin I.
collection PubMed
description Ion channels contribute fundamental properties to cell membranes. Although highly diverse in conductivity, structure, location, and function, many of them can be regulated by common mechanisms, such as voltage or (de-)phosphorylation. Primarily considering ion channels involved in the nociceptive system, this review covers more novel and less known features. Accordingly, we outline noncanonical operation of voltage-gated sodium, potassium, transient receptor potential (TRP), and hyperpolarization-activated cyclic nucleotide (HCN)-gated channels. Noncanonical features discussed include properties as a memory for prior voltage and chemical exposure, alternative ion conduction pathways, cluster formation, and silent subunits. Complementary to this main focus, the intention is also to transfer knowledge between fields, which become inevitably more separate due to their size.
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spelling pubmed-67706262019-10-30 Noncanonical Ion Channel Behaviour in Pain Ciotu, Cosmin I. Tsantoulas, Christoforos Meents, Jannis Lampert, Angelika McMahon, Stephen B. Ludwig, Andreas Fischer, Michael J.M. Int J Mol Sci Review Ion channels contribute fundamental properties to cell membranes. Although highly diverse in conductivity, structure, location, and function, many of them can be regulated by common mechanisms, such as voltage or (de-)phosphorylation. Primarily considering ion channels involved in the nociceptive system, this review covers more novel and less known features. Accordingly, we outline noncanonical operation of voltage-gated sodium, potassium, transient receptor potential (TRP), and hyperpolarization-activated cyclic nucleotide (HCN)-gated channels. Noncanonical features discussed include properties as a memory for prior voltage and chemical exposure, alternative ion conduction pathways, cluster formation, and silent subunits. Complementary to this main focus, the intention is also to transfer knowledge between fields, which become inevitably more separate due to their size. MDPI 2019-09-15 /pmc/articles/PMC6770626/ /pubmed/31540178 http://dx.doi.org/10.3390/ijms20184572 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ciotu, Cosmin I.
Tsantoulas, Christoforos
Meents, Jannis
Lampert, Angelika
McMahon, Stephen B.
Ludwig, Andreas
Fischer, Michael J.M.
Noncanonical Ion Channel Behaviour in Pain
title Noncanonical Ion Channel Behaviour in Pain
title_full Noncanonical Ion Channel Behaviour in Pain
title_fullStr Noncanonical Ion Channel Behaviour in Pain
title_full_unstemmed Noncanonical Ion Channel Behaviour in Pain
title_short Noncanonical Ion Channel Behaviour in Pain
title_sort noncanonical ion channel behaviour in pain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770626/
https://www.ncbi.nlm.nih.gov/pubmed/31540178
http://dx.doi.org/10.3390/ijms20184572
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