Cargando…

Expression of Renin-Angiotensin System Components in the Taste Organ of Mice

The systemic renin-angiotensin system (RAS) is an important regulator of body fluid and sodium homeostasis. Angiotensin II (AngII) is a key active product of the RAS. We previously revealed that circulating AngII suppresses amiloride-sensitive salt taste responses and enhances the responses to sweet...

Descripción completa

Detalles Bibliográficos
Autores principales: Shigemura, Noriatsu, Takai, Shingo, Hirose, Fumie, Yoshida, Ryusuke, Sanematsu, Keisuke, Ninomiya, Yuzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770651/
https://www.ncbi.nlm.nih.gov/pubmed/31546789
http://dx.doi.org/10.3390/nu11092251
_version_ 1783455525729468416
author Shigemura, Noriatsu
Takai, Shingo
Hirose, Fumie
Yoshida, Ryusuke
Sanematsu, Keisuke
Ninomiya, Yuzo
author_facet Shigemura, Noriatsu
Takai, Shingo
Hirose, Fumie
Yoshida, Ryusuke
Sanematsu, Keisuke
Ninomiya, Yuzo
author_sort Shigemura, Noriatsu
collection PubMed
description The systemic renin-angiotensin system (RAS) is an important regulator of body fluid and sodium homeostasis. Angiotensin II (AngII) is a key active product of the RAS. We previously revealed that circulating AngII suppresses amiloride-sensitive salt taste responses and enhances the responses to sweet compounds via the AngII type 1 receptor (AT1) expressed in taste cells. However, the molecular mechanisms underlying the modulation of taste function by AngII remain uncharacterized. Here we examined the expression of three RAS components, namely renin, angiotensinogen, and angiotensin-converting enzyme-1 (ACE1), in mouse taste tissues. We found that all three RAS components were present in the taste buds of fungiform and circumvallate papillae and co-expressed with αENaC (epithelial sodium channel α-subunit, a salt taste receptor) or T1R3 (taste receptor type 1 member 3, a sweet taste receptor component). Water-deprived mice exhibited significantly increased levels of renin expression in taste cells (p < 0.05). These results indicate the existence of a local RAS in the taste organ and suggest that taste function may be regulated by both locally-produced and circulating AngII. Such integrated modulation of peripheral taste sensitivity by AngII may play an important role in sodium/calorie homeostasis.
format Online
Article
Text
id pubmed-6770651
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-67706512019-10-30 Expression of Renin-Angiotensin System Components in the Taste Organ of Mice Shigemura, Noriatsu Takai, Shingo Hirose, Fumie Yoshida, Ryusuke Sanematsu, Keisuke Ninomiya, Yuzo Nutrients Article The systemic renin-angiotensin system (RAS) is an important regulator of body fluid and sodium homeostasis. Angiotensin II (AngII) is a key active product of the RAS. We previously revealed that circulating AngII suppresses amiloride-sensitive salt taste responses and enhances the responses to sweet compounds via the AngII type 1 receptor (AT1) expressed in taste cells. However, the molecular mechanisms underlying the modulation of taste function by AngII remain uncharacterized. Here we examined the expression of three RAS components, namely renin, angiotensinogen, and angiotensin-converting enzyme-1 (ACE1), in mouse taste tissues. We found that all three RAS components were present in the taste buds of fungiform and circumvallate papillae and co-expressed with αENaC (epithelial sodium channel α-subunit, a salt taste receptor) or T1R3 (taste receptor type 1 member 3, a sweet taste receptor component). Water-deprived mice exhibited significantly increased levels of renin expression in taste cells (p < 0.05). These results indicate the existence of a local RAS in the taste organ and suggest that taste function may be regulated by both locally-produced and circulating AngII. Such integrated modulation of peripheral taste sensitivity by AngII may play an important role in sodium/calorie homeostasis. MDPI 2019-09-19 /pmc/articles/PMC6770651/ /pubmed/31546789 http://dx.doi.org/10.3390/nu11092251 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shigemura, Noriatsu
Takai, Shingo
Hirose, Fumie
Yoshida, Ryusuke
Sanematsu, Keisuke
Ninomiya, Yuzo
Expression of Renin-Angiotensin System Components in the Taste Organ of Mice
title Expression of Renin-Angiotensin System Components in the Taste Organ of Mice
title_full Expression of Renin-Angiotensin System Components in the Taste Organ of Mice
title_fullStr Expression of Renin-Angiotensin System Components in the Taste Organ of Mice
title_full_unstemmed Expression of Renin-Angiotensin System Components in the Taste Organ of Mice
title_short Expression of Renin-Angiotensin System Components in the Taste Organ of Mice
title_sort expression of renin-angiotensin system components in the taste organ of mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770651/
https://www.ncbi.nlm.nih.gov/pubmed/31546789
http://dx.doi.org/10.3390/nu11092251
work_keys_str_mv AT shigemuranoriatsu expressionofreninangiotensinsystemcomponentsinthetasteorganofmice
AT takaishingo expressionofreninangiotensinsystemcomponentsinthetasteorganofmice
AT hirosefumie expressionofreninangiotensinsystemcomponentsinthetasteorganofmice
AT yoshidaryusuke expressionofreninangiotensinsystemcomponentsinthetasteorganofmice
AT sanematsukeisuke expressionofreninangiotensinsystemcomponentsinthetasteorganofmice
AT ninomiyayuzo expressionofreninangiotensinsystemcomponentsinthetasteorganofmice