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The Cynomolgus Macaque MHC Polymorphism in Experimental Medicine

Among the non-human primates used in experimental medicine, cynomolgus macaques (Macaca fascicularis hereafter referred to as Mafa) are increasingly selected for the ease with which they are maintained and bred in captivity. Macaques belong to Old World monkeys and are phylogenetically much closer t...

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Autores principales: Shiina, Takashi, Blancher, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770713/
https://www.ncbi.nlm.nih.gov/pubmed/31455025
http://dx.doi.org/10.3390/cells8090978
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author Shiina, Takashi
Blancher, Antoine
author_facet Shiina, Takashi
Blancher, Antoine
author_sort Shiina, Takashi
collection PubMed
description Among the non-human primates used in experimental medicine, cynomolgus macaques (Macaca fascicularis hereafter referred to as Mafa) are increasingly selected for the ease with which they are maintained and bred in captivity. Macaques belong to Old World monkeys and are phylogenetically much closer to humans than rodents, which are still the most frequently used animal model. Our understanding of the Mafa genome has progressed rapidly in recent years and has greatly benefited from the latest technical advances in molecular genetics. Cynomolgus macaques are widespread in Southeast Asia and numerous studies have shown a distinct genetic differentiation of continental and island populations. The major histocompatibility complex of cynomolgus macaque (Mafa MHC) is organized in the same way as that of human, but it differs from the latter by its high degree of classical class I gene duplication. Human polymorphic MHC regions play a pivotal role in allograft transplantation and have been associated with more than 100 diseases and/or phenotypes. The Mafa MHC polymorphism similarly plays a crucial role in experimental allografts of organs and stem cells. Experimental results show that the Mafa MHC class I and II regions influence the ability to mount an immune response against infectious pathogens and vaccines. MHC also affects cynomolgus macaque reproduction and impacts on numerous biological parameters. This review describes the Mafa MHC polymorphism and the methods currently used to characterize it. We discuss some of the major areas of experimental medicine where an effect induced by MHC polymorphism has been demonstrated.
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spelling pubmed-67707132019-10-30 The Cynomolgus Macaque MHC Polymorphism in Experimental Medicine Shiina, Takashi Blancher, Antoine Cells Review Among the non-human primates used in experimental medicine, cynomolgus macaques (Macaca fascicularis hereafter referred to as Mafa) are increasingly selected for the ease with which they are maintained and bred in captivity. Macaques belong to Old World monkeys and are phylogenetically much closer to humans than rodents, which are still the most frequently used animal model. Our understanding of the Mafa genome has progressed rapidly in recent years and has greatly benefited from the latest technical advances in molecular genetics. Cynomolgus macaques are widespread in Southeast Asia and numerous studies have shown a distinct genetic differentiation of continental and island populations. The major histocompatibility complex of cynomolgus macaque (Mafa MHC) is organized in the same way as that of human, but it differs from the latter by its high degree of classical class I gene duplication. Human polymorphic MHC regions play a pivotal role in allograft transplantation and have been associated with more than 100 diseases and/or phenotypes. The Mafa MHC polymorphism similarly plays a crucial role in experimental allografts of organs and stem cells. Experimental results show that the Mafa MHC class I and II regions influence the ability to mount an immune response against infectious pathogens and vaccines. MHC also affects cynomolgus macaque reproduction and impacts on numerous biological parameters. This review describes the Mafa MHC polymorphism and the methods currently used to characterize it. We discuss some of the major areas of experimental medicine where an effect induced by MHC polymorphism has been demonstrated. MDPI 2019-08-26 /pmc/articles/PMC6770713/ /pubmed/31455025 http://dx.doi.org/10.3390/cells8090978 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shiina, Takashi
Blancher, Antoine
The Cynomolgus Macaque MHC Polymorphism in Experimental Medicine
title The Cynomolgus Macaque MHC Polymorphism in Experimental Medicine
title_full The Cynomolgus Macaque MHC Polymorphism in Experimental Medicine
title_fullStr The Cynomolgus Macaque MHC Polymorphism in Experimental Medicine
title_full_unstemmed The Cynomolgus Macaque MHC Polymorphism in Experimental Medicine
title_short The Cynomolgus Macaque MHC Polymorphism in Experimental Medicine
title_sort cynomolgus macaque mhc polymorphism in experimental medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770713/
https://www.ncbi.nlm.nih.gov/pubmed/31455025
http://dx.doi.org/10.3390/cells8090978
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