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Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma

Background: Local recurrence after radiotherapy for T2 glottic carcinoma remains an issue and identifying patients at risk for relapse is, therefore, important. This study aimed to assess the oncological outcomes and prognostic factors in a consecutive series of patients treated with radiotherapy fo...

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Autores principales: Hendriksma, Martine, van Ruler, Marc A.P., Verbist, Berit M., de Jong, Martin A., Langeveld, Ton P.M., van Benthem, Peter Paul G., Sjögren, Elisabeth V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770714/
https://www.ncbi.nlm.nih.gov/pubmed/31500162
http://dx.doi.org/10.3390/cancers11091319
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author Hendriksma, Martine
van Ruler, Marc A.P.
Verbist, Berit M.
de Jong, Martin A.
Langeveld, Ton P.M.
van Benthem, Peter Paul G.
Sjögren, Elisabeth V.
author_facet Hendriksma, Martine
van Ruler, Marc A.P.
Verbist, Berit M.
de Jong, Martin A.
Langeveld, Ton P.M.
van Benthem, Peter Paul G.
Sjögren, Elisabeth V.
author_sort Hendriksma, Martine
collection PubMed
description Background: Local recurrence after radiotherapy for T2 glottic carcinoma remains an issue and identifying patients at risk for relapse is, therefore, important. This study aimed to assess the oncological outcomes and prognostic factors in a consecutive series of patients treated with radiotherapy for T2N0 glottic carcinoma. Methods: Patients with T2N0 glottic carcinoma treated with radiotherapy were included in this retrospective study. Five- and ten-year local control (LC), overall survival (OS), disease-specific survival (DSS), and laryngeal preservation (LP) rates were calculated with the Kaplan–Meier method. The impact of prognostic variables was evaluated with the log-rank test. Results: Ninety-four patients were included for analysis. LC, OS, DSS, and LP rates were 70.5, 63.7, 86.0, and 74.7%, respectively at five years and 65.8, 41.0, 75.6, and 72.4% at 10 years. In total, 46 scans were included in the analyses. Vertical involvement of the anterior commissure on imaging showed a significant impact on LC. Conclusions: In accordance with previously described surgical risk factors, we identified vertical involvement of the anterior commissure on imaging as a prognostic factor for radiation failure.
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spelling pubmed-67707142019-10-30 Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma Hendriksma, Martine van Ruler, Marc A.P. Verbist, Berit M. de Jong, Martin A. Langeveld, Ton P.M. van Benthem, Peter Paul G. Sjögren, Elisabeth V. Cancers (Basel) Article Background: Local recurrence after radiotherapy for T2 glottic carcinoma remains an issue and identifying patients at risk for relapse is, therefore, important. This study aimed to assess the oncological outcomes and prognostic factors in a consecutive series of patients treated with radiotherapy for T2N0 glottic carcinoma. Methods: Patients with T2N0 glottic carcinoma treated with radiotherapy were included in this retrospective study. Five- and ten-year local control (LC), overall survival (OS), disease-specific survival (DSS), and laryngeal preservation (LP) rates were calculated with the Kaplan–Meier method. The impact of prognostic variables was evaluated with the log-rank test. Results: Ninety-four patients were included for analysis. LC, OS, DSS, and LP rates were 70.5, 63.7, 86.0, and 74.7%, respectively at five years and 65.8, 41.0, 75.6, and 72.4% at 10 years. In total, 46 scans were included in the analyses. Vertical involvement of the anterior commissure on imaging showed a significant impact on LC. Conclusions: In accordance with previously described surgical risk factors, we identified vertical involvement of the anterior commissure on imaging as a prognostic factor for radiation failure. MDPI 2019-09-06 /pmc/articles/PMC6770714/ /pubmed/31500162 http://dx.doi.org/10.3390/cancers11091319 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hendriksma, Martine
van Ruler, Marc A.P.
Verbist, Berit M.
de Jong, Martin A.
Langeveld, Ton P.M.
van Benthem, Peter Paul G.
Sjögren, Elisabeth V.
Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma
title Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma
title_full Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma
title_fullStr Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma
title_full_unstemmed Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma
title_short Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma
title_sort survival and prognostic factors for outcome after radiotherapy for t2 glottic carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770714/
https://www.ncbi.nlm.nih.gov/pubmed/31500162
http://dx.doi.org/10.3390/cancers11091319
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