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Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma
Background: Local recurrence after radiotherapy for T2 glottic carcinoma remains an issue and identifying patients at risk for relapse is, therefore, important. This study aimed to assess the oncological outcomes and prognostic factors in a consecutive series of patients treated with radiotherapy fo...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770714/ https://www.ncbi.nlm.nih.gov/pubmed/31500162 http://dx.doi.org/10.3390/cancers11091319 |
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author | Hendriksma, Martine van Ruler, Marc A.P. Verbist, Berit M. de Jong, Martin A. Langeveld, Ton P.M. van Benthem, Peter Paul G. Sjögren, Elisabeth V. |
author_facet | Hendriksma, Martine van Ruler, Marc A.P. Verbist, Berit M. de Jong, Martin A. Langeveld, Ton P.M. van Benthem, Peter Paul G. Sjögren, Elisabeth V. |
author_sort | Hendriksma, Martine |
collection | PubMed |
description | Background: Local recurrence after radiotherapy for T2 glottic carcinoma remains an issue and identifying patients at risk for relapse is, therefore, important. This study aimed to assess the oncological outcomes and prognostic factors in a consecutive series of patients treated with radiotherapy for T2N0 glottic carcinoma. Methods: Patients with T2N0 glottic carcinoma treated with radiotherapy were included in this retrospective study. Five- and ten-year local control (LC), overall survival (OS), disease-specific survival (DSS), and laryngeal preservation (LP) rates were calculated with the Kaplan–Meier method. The impact of prognostic variables was evaluated with the log-rank test. Results: Ninety-four patients were included for analysis. LC, OS, DSS, and LP rates were 70.5, 63.7, 86.0, and 74.7%, respectively at five years and 65.8, 41.0, 75.6, and 72.4% at 10 years. In total, 46 scans were included in the analyses. Vertical involvement of the anterior commissure on imaging showed a significant impact on LC. Conclusions: In accordance with previously described surgical risk factors, we identified vertical involvement of the anterior commissure on imaging as a prognostic factor for radiation failure. |
format | Online Article Text |
id | pubmed-6770714 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67707142019-10-30 Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma Hendriksma, Martine van Ruler, Marc A.P. Verbist, Berit M. de Jong, Martin A. Langeveld, Ton P.M. van Benthem, Peter Paul G. Sjögren, Elisabeth V. Cancers (Basel) Article Background: Local recurrence after radiotherapy for T2 glottic carcinoma remains an issue and identifying patients at risk for relapse is, therefore, important. This study aimed to assess the oncological outcomes and prognostic factors in a consecutive series of patients treated with radiotherapy for T2N0 glottic carcinoma. Methods: Patients with T2N0 glottic carcinoma treated with radiotherapy were included in this retrospective study. Five- and ten-year local control (LC), overall survival (OS), disease-specific survival (DSS), and laryngeal preservation (LP) rates were calculated with the Kaplan–Meier method. The impact of prognostic variables was evaluated with the log-rank test. Results: Ninety-four patients were included for analysis. LC, OS, DSS, and LP rates were 70.5, 63.7, 86.0, and 74.7%, respectively at five years and 65.8, 41.0, 75.6, and 72.4% at 10 years. In total, 46 scans were included in the analyses. Vertical involvement of the anterior commissure on imaging showed a significant impact on LC. Conclusions: In accordance with previously described surgical risk factors, we identified vertical involvement of the anterior commissure on imaging as a prognostic factor for radiation failure. MDPI 2019-09-06 /pmc/articles/PMC6770714/ /pubmed/31500162 http://dx.doi.org/10.3390/cancers11091319 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hendriksma, Martine van Ruler, Marc A.P. Verbist, Berit M. de Jong, Martin A. Langeveld, Ton P.M. van Benthem, Peter Paul G. Sjögren, Elisabeth V. Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma |
title | Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma |
title_full | Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma |
title_fullStr | Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma |
title_full_unstemmed | Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma |
title_short | Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma |
title_sort | survival and prognostic factors for outcome after radiotherapy for t2 glottic carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770714/ https://www.ncbi.nlm.nih.gov/pubmed/31500162 http://dx.doi.org/10.3390/cancers11091319 |
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