Cargando…

The Diagnostic Significance of PDGF, EphA7, CCR5, and CCL5 Levels in Colorectal Cancer

In this study, we compared the levels of C-C chemokine receptor type 5 (CCR5), C-C motif chemokine ligand 5 (CCL5), platelet-derived growth factor (PDGF), and EphrinA7 (EphA7) in patients with colorectal carcinoma and healthy controls in order to investigate the significance and usability of these p...

Descripción completa

Detalles Bibliográficos
Autores principales: Üçüncü, Muhammed, Serilmez, Murat, Sarı, Murat, Bademler, Süleyman, Karabulut, Senem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770732/
https://www.ncbi.nlm.nih.gov/pubmed/31505877
http://dx.doi.org/10.3390/biom9090464
_version_ 1783455547792556032
author Üçüncü, Muhammed
Serilmez, Murat
Sarı, Murat
Bademler, Süleyman
Karabulut, Senem
author_facet Üçüncü, Muhammed
Serilmez, Murat
Sarı, Murat
Bademler, Süleyman
Karabulut, Senem
author_sort Üçüncü, Muhammed
collection PubMed
description In this study, we compared the levels of C-C chemokine receptor type 5 (CCR5), C-C motif chemokine ligand 5 (CCL5), platelet-derived growth factor (PDGF), and EphrinA7 (EphA7) in patients with colorectal carcinoma and healthy controls in order to investigate the significance and usability of these potential biomarkers in early diagnosis of colorectal cancer. The study included 70 colorectal carcinoma patients and 40 healthy individuals. The CCR5, CCL5, PDGF, and EphA7 levels were measured using ELISA in blood samples. PDGF-BB, EphA7, CCR5, and CCL5 levels of the patients with colorectal carcinoma were significantly higher compared to the control group (p < 0.001 for each comparison). Our logistic regression analysis (the area under the curve was 0.958) supports the notion that PDGF-BB, EphA7, and CCL5 are potential biomarkers for the diagnosis of colon cancer. The sensitivity, specificity, and positive and negative predictive values were found to be 87.9%, 87.5%, 92.1%, and 81.4%, respectively. To our knowledge, this is the first study that investigates the relationship between colorectal carcinoma and the four biomarkers CCL5, CCR5, PDGF, and EphA7. The significantly elevated levels of all these parameters in the patient group compared to the healthy controls indicate that they can be used for the early diagnosis of colorectal carcinoma.
format Online
Article
Text
id pubmed-6770732
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-67707322019-10-30 The Diagnostic Significance of PDGF, EphA7, CCR5, and CCL5 Levels in Colorectal Cancer Üçüncü, Muhammed Serilmez, Murat Sarı, Murat Bademler, Süleyman Karabulut, Senem Biomolecules Article In this study, we compared the levels of C-C chemokine receptor type 5 (CCR5), C-C motif chemokine ligand 5 (CCL5), platelet-derived growth factor (PDGF), and EphrinA7 (EphA7) in patients with colorectal carcinoma and healthy controls in order to investigate the significance and usability of these potential biomarkers in early diagnosis of colorectal cancer. The study included 70 colorectal carcinoma patients and 40 healthy individuals. The CCR5, CCL5, PDGF, and EphA7 levels were measured using ELISA in blood samples. PDGF-BB, EphA7, CCR5, and CCL5 levels of the patients with colorectal carcinoma were significantly higher compared to the control group (p < 0.001 for each comparison). Our logistic regression analysis (the area under the curve was 0.958) supports the notion that PDGF-BB, EphA7, and CCL5 are potential biomarkers for the diagnosis of colon cancer. The sensitivity, specificity, and positive and negative predictive values were found to be 87.9%, 87.5%, 92.1%, and 81.4%, respectively. To our knowledge, this is the first study that investigates the relationship between colorectal carcinoma and the four biomarkers CCL5, CCR5, PDGF, and EphA7. The significantly elevated levels of all these parameters in the patient group compared to the healthy controls indicate that they can be used for the early diagnosis of colorectal carcinoma. MDPI 2019-09-09 /pmc/articles/PMC6770732/ /pubmed/31505877 http://dx.doi.org/10.3390/biom9090464 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Üçüncü, Muhammed
Serilmez, Murat
Sarı, Murat
Bademler, Süleyman
Karabulut, Senem
The Diagnostic Significance of PDGF, EphA7, CCR5, and CCL5 Levels in Colorectal Cancer
title The Diagnostic Significance of PDGF, EphA7, CCR5, and CCL5 Levels in Colorectal Cancer
title_full The Diagnostic Significance of PDGF, EphA7, CCR5, and CCL5 Levels in Colorectal Cancer
title_fullStr The Diagnostic Significance of PDGF, EphA7, CCR5, and CCL5 Levels in Colorectal Cancer
title_full_unstemmed The Diagnostic Significance of PDGF, EphA7, CCR5, and CCL5 Levels in Colorectal Cancer
title_short The Diagnostic Significance of PDGF, EphA7, CCR5, and CCL5 Levels in Colorectal Cancer
title_sort diagnostic significance of pdgf, epha7, ccr5, and ccl5 levels in colorectal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770732/
https://www.ncbi.nlm.nih.gov/pubmed/31505877
http://dx.doi.org/10.3390/biom9090464
work_keys_str_mv AT ucuncumuhammed thediagnosticsignificanceofpdgfepha7ccr5andccl5levelsincolorectalcancer
AT serilmezmurat thediagnosticsignificanceofpdgfepha7ccr5andccl5levelsincolorectalcancer
AT sarımurat thediagnosticsignificanceofpdgfepha7ccr5andccl5levelsincolorectalcancer
AT bademlersuleyman thediagnosticsignificanceofpdgfepha7ccr5andccl5levelsincolorectalcancer
AT karabulutsenem thediagnosticsignificanceofpdgfepha7ccr5andccl5levelsincolorectalcancer
AT ucuncumuhammed diagnosticsignificanceofpdgfepha7ccr5andccl5levelsincolorectalcancer
AT serilmezmurat diagnosticsignificanceofpdgfepha7ccr5andccl5levelsincolorectalcancer
AT sarımurat diagnosticsignificanceofpdgfepha7ccr5andccl5levelsincolorectalcancer
AT bademlersuleyman diagnosticsignificanceofpdgfepha7ccr5andccl5levelsincolorectalcancer
AT karabulutsenem diagnosticsignificanceofpdgfepha7ccr5andccl5levelsincolorectalcancer