Cargando…
The Diagnostic Significance of PDGF, EphA7, CCR5, and CCL5 Levels in Colorectal Cancer
In this study, we compared the levels of C-C chemokine receptor type 5 (CCR5), C-C motif chemokine ligand 5 (CCL5), platelet-derived growth factor (PDGF), and EphrinA7 (EphA7) in patients with colorectal carcinoma and healthy controls in order to investigate the significance and usability of these p...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770732/ https://www.ncbi.nlm.nih.gov/pubmed/31505877 http://dx.doi.org/10.3390/biom9090464 |
_version_ | 1783455547792556032 |
---|---|
author | Üçüncü, Muhammed Serilmez, Murat Sarı, Murat Bademler, Süleyman Karabulut, Senem |
author_facet | Üçüncü, Muhammed Serilmez, Murat Sarı, Murat Bademler, Süleyman Karabulut, Senem |
author_sort | Üçüncü, Muhammed |
collection | PubMed |
description | In this study, we compared the levels of C-C chemokine receptor type 5 (CCR5), C-C motif chemokine ligand 5 (CCL5), platelet-derived growth factor (PDGF), and EphrinA7 (EphA7) in patients with colorectal carcinoma and healthy controls in order to investigate the significance and usability of these potential biomarkers in early diagnosis of colorectal cancer. The study included 70 colorectal carcinoma patients and 40 healthy individuals. The CCR5, CCL5, PDGF, and EphA7 levels were measured using ELISA in blood samples. PDGF-BB, EphA7, CCR5, and CCL5 levels of the patients with colorectal carcinoma were significantly higher compared to the control group (p < 0.001 for each comparison). Our logistic regression analysis (the area under the curve was 0.958) supports the notion that PDGF-BB, EphA7, and CCL5 are potential biomarkers for the diagnosis of colon cancer. The sensitivity, specificity, and positive and negative predictive values were found to be 87.9%, 87.5%, 92.1%, and 81.4%, respectively. To our knowledge, this is the first study that investigates the relationship between colorectal carcinoma and the four biomarkers CCL5, CCR5, PDGF, and EphA7. The significantly elevated levels of all these parameters in the patient group compared to the healthy controls indicate that they can be used for the early diagnosis of colorectal carcinoma. |
format | Online Article Text |
id | pubmed-6770732 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67707322019-10-30 The Diagnostic Significance of PDGF, EphA7, CCR5, and CCL5 Levels in Colorectal Cancer Üçüncü, Muhammed Serilmez, Murat Sarı, Murat Bademler, Süleyman Karabulut, Senem Biomolecules Article In this study, we compared the levels of C-C chemokine receptor type 5 (CCR5), C-C motif chemokine ligand 5 (CCL5), platelet-derived growth factor (PDGF), and EphrinA7 (EphA7) in patients with colorectal carcinoma and healthy controls in order to investigate the significance and usability of these potential biomarkers in early diagnosis of colorectal cancer. The study included 70 colorectal carcinoma patients and 40 healthy individuals. The CCR5, CCL5, PDGF, and EphA7 levels were measured using ELISA in blood samples. PDGF-BB, EphA7, CCR5, and CCL5 levels of the patients with colorectal carcinoma were significantly higher compared to the control group (p < 0.001 for each comparison). Our logistic regression analysis (the area under the curve was 0.958) supports the notion that PDGF-BB, EphA7, and CCL5 are potential biomarkers for the diagnosis of colon cancer. The sensitivity, specificity, and positive and negative predictive values were found to be 87.9%, 87.5%, 92.1%, and 81.4%, respectively. To our knowledge, this is the first study that investigates the relationship between colorectal carcinoma and the four biomarkers CCL5, CCR5, PDGF, and EphA7. The significantly elevated levels of all these parameters in the patient group compared to the healthy controls indicate that they can be used for the early diagnosis of colorectal carcinoma. MDPI 2019-09-09 /pmc/articles/PMC6770732/ /pubmed/31505877 http://dx.doi.org/10.3390/biom9090464 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Üçüncü, Muhammed Serilmez, Murat Sarı, Murat Bademler, Süleyman Karabulut, Senem The Diagnostic Significance of PDGF, EphA7, CCR5, and CCL5 Levels in Colorectal Cancer |
title | The Diagnostic Significance of PDGF, EphA7, CCR5, and CCL5 Levels in Colorectal Cancer |
title_full | The Diagnostic Significance of PDGF, EphA7, CCR5, and CCL5 Levels in Colorectal Cancer |
title_fullStr | The Diagnostic Significance of PDGF, EphA7, CCR5, and CCL5 Levels in Colorectal Cancer |
title_full_unstemmed | The Diagnostic Significance of PDGF, EphA7, CCR5, and CCL5 Levels in Colorectal Cancer |
title_short | The Diagnostic Significance of PDGF, EphA7, CCR5, and CCL5 Levels in Colorectal Cancer |
title_sort | diagnostic significance of pdgf, epha7, ccr5, and ccl5 levels in colorectal cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770732/ https://www.ncbi.nlm.nih.gov/pubmed/31505877 http://dx.doi.org/10.3390/biom9090464 |
work_keys_str_mv | AT ucuncumuhammed thediagnosticsignificanceofpdgfepha7ccr5andccl5levelsincolorectalcancer AT serilmezmurat thediagnosticsignificanceofpdgfepha7ccr5andccl5levelsincolorectalcancer AT sarımurat thediagnosticsignificanceofpdgfepha7ccr5andccl5levelsincolorectalcancer AT bademlersuleyman thediagnosticsignificanceofpdgfepha7ccr5andccl5levelsincolorectalcancer AT karabulutsenem thediagnosticsignificanceofpdgfepha7ccr5andccl5levelsincolorectalcancer AT ucuncumuhammed diagnosticsignificanceofpdgfepha7ccr5andccl5levelsincolorectalcancer AT serilmezmurat diagnosticsignificanceofpdgfepha7ccr5andccl5levelsincolorectalcancer AT sarımurat diagnosticsignificanceofpdgfepha7ccr5andccl5levelsincolorectalcancer AT bademlersuleyman diagnosticsignificanceofpdgfepha7ccr5andccl5levelsincolorectalcancer AT karabulutsenem diagnosticsignificanceofpdgfepha7ccr5andccl5levelsincolorectalcancer |