Cargando…

Adipose Mesenchymal Extracellular Vesicles as Alpha-1-Antitrypsin Physiological Delivery Systems for Lung Regeneration

Accumulating evidence shows that Mesenchymal Stem/Stromal Cells (MSCs) exert their therapeutic effects by the release of secretome, made of both soluble proteins and nano/microstructured extracellular vesicles (EVs). In this work, for the first time, we proved by a proteomic investigation that adipo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bari, Elia, Ferrarotti, Ilaria, Di Silvestre, Dario, Grisoli, Pietro, Barzon, Valentina, Balderacchi, Alice, Torre, Maria Luisa, Rossi, Rossana, Mauri, Pierluigi, Corsico, Angelo Guido, Perteghella, Sara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770759/ https://www.ncbi.nlm.nih.gov/pubmed/31450843 http://dx.doi.org/10.3390/cells8090965

Ejemplares similares

COVID-19 infection in severe Alpha 1-antitrypsin deficiency: Looking for a rationale
por: Ferrarotti, I., et al.
Publicado: (2021)

Molecular diagnosis of alpha1‐antitrypsin deficiency: A new method based on Luminex technology
por: Ottaviani, Stefania, et al.
Publicado: (2020)

Improving the Laboratory Diagnosis of M-like Variants Related to Alpha1-Antitrypsin Deficiency
por: Barzon, Valentina, et al.
Publicado: (2022)

Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use
por: Bari, Elia, et al.
Publicado: (2020)

Case-finding for alpha1-antitrypsin deficiency in Kazakh patients with COPD
por: Zhumagaliyeva, Ardak, et al.
Publicado: (2017)

Mesenchymal Stromal Cell Secretome for Post-COVID-19 Pulmonary Fibrosis: A New Therapy to Treat the Long-Term Lung Sequelae?
por: Bari, Elia, et al.
Publicado: (2021)

Update on α(1)-antitrypsin deficiency
por: Ferrarotti, Ilaria, et al.
Publicado: (2018)

The Importance of N186 in the Alpha-1-Antitrypsin Shutter Region Is Revealed by the Novel Bologna Deficiency Variant
por: Ronzoni, Riccardo, et al.
Publicado: (2021)

Alpha 1 antitrypsin to treat lung disease in alpha 1 antitrypsin deficiency: recent developments and clinical implications
por: Chapman, Kenneth R, et al.
Publicado: (2018)

Pilot Production of Mesenchymal Stem/Stromal Freeze-Dried Secretome for Cell-Free Regenerative Nanomedicine: A Validated GMP-Compliant Process
por: Bari, Elia, et al.
Publicado: (2018)

New Patient-Centric Approaches to the Management of Alpha-1 Antitrypsin Deficiency
por: Chorostowska-Wynimko, Joanna, et al.
Publicado: (2020)

Bacterial load and inflammatory response in sputum of alpha-1 antitrypsin deficiency patients with COPD
por: Balbi, Bruno, et al.
Publicado: (2019)

Silk Fibroin Bioink for 3D Printing in Tissue Regeneration: Controlled Release of MSC extracellular Vesicles
por: Bari, Elia, et al.
Publicado: (2023)

Alternative transcripts of the SERPINA1 gene in alpha-1 antitrypsin deficiency
por: Matamala, Nerea, et al.
Publicado: (2015)

Clinical manifestations in patients with PI*MM(Malton) genotypes. A matter still unsolved in alpha‐1 antitrypsin deficiency
por: Aiello, Marina, et al.
Publicado: (2020)

How Can We Improve the Detection of Alpha1-Antitrypsin Deficiency?
por: Ferrarotti, Ilaria, et al.
Publicado: (2015)

Alpha-1 Antitrypsin Screening in a Selected Cohort of Patients Affected by Chronic Pulmonary Diseases in Naples, Italy
por: Annunziata, Anna, et al.
Publicado: (2021)

Clinical manifestations of a new alpha‐1 antitrypsin genetic variant: Q0parma
por: Aiello, Marina, et al.
Publicado: (2022)

Screening for Alpha 1 antitrypsin deficiency in Tunisian subjects with obstructive lung disease: a feasibility report
por: Denden, Sabri, et al.
Publicado: (2009)

Exome Sequencing Reveals Immune Genes as Susceptibility Modifiers in Individuals with α(1)-Antitrypsin Deficiency
por: Rigobello, Chiara, et al.
Publicado: (2019)

Trojan-horse silk fibroin nanocarriers loaded with a re-call antigen to redirect immunity against cancer
por: Bari, Elia, et al.
Publicado: (2023)

The role of bronchial epithelial cells in the pathogenesis of COPD in Z-alpha-1 antitrypsin deficiency
por: Pini, Laura, et al.
Publicado: (2014)

The pathological Trento variant of alpha‐1‐antitrypsin (E75V) shows nonclassical behaviour during polymerization
por: Miranda, Elena, et al.
Publicado: (2017)

Biohybrid Bovine Bone Matrix for Controlled Release of Mesenchymal Stem/Stromal Cell Lyosecretome: A Device for Bone Regeneration
por: Bari, Elia, et al.
Publicado: (2021)

Severe alpha-1 antitrypsin deficiency in composite heterozygotes inheriting a new splicing mutation QO(Madrid)
por: Lara, Beatriz, et al.
Publicado: (2014)

Mineralization of alpha-1-antitrypsin inclusion bodies in Mmalton alpha-1-antitrypsin deficiency
por: Callea, Francesco, et al.
Publicado: (2018)

Long-term effect of α(1)-antitrypsin augmentation therapy on the decline of FEV(1) in deficient patients: an analysis of the AIR database
por: Schouten, Iris G.M., et al.
Publicado: (2021)

Sericin/crocetin micro/nanoparticles for nucleus pulposus cells regeneration: An “active” drug delivery system
por: Bari, Elia, et al.
Publicado: (2023)

Three New Alpha1-Antitrypsin Deficiency Variants Help to Define a C-Terminal Region Regulating Conformational Change and Polymerization
por: Fra, Anna M., et al.
Publicado: (2012)

Three-Dimensional Bioprinted Controlled Release Scaffold Containing Mesenchymal Stem/Stromal Lyosecretome for Bone Regeneration: Sterile Manufacturing and In Vitro Biological Efficacy
por: Bari, Elia, et al.
Publicado: (2022)

Gene therapy for alpha 1-antitrypsin deficiency with an oxidant-resistant human alpha 1-antitrypsin
por: Sosulski, Meredith L., et al.
Publicado: (2020)

Alpha-1 Antitrypsin as a Therapeutic Agent for Conditions not Associated with Alpha-1 Antitrypsin Deficiency
por: Wanner, Adam
Publicado: (2015)

Alpha-1 antitrypsin deficient individuals have circulating extracellular vesicles with profibrogenic cargo
por: Khodayari, Nazli, et al.
Publicado: (2020)

The Genes–Stemness–Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints
por: Stella, Giulia M., et al.
Publicado: (2023)

Growth Factors Delivery System for Skin Regeneration: An Advanced Wound Dressing
por: Nardini, Marta, et al.
Publicado: (2020)

Krüppel-like zinc finger proteins in end-stage COPD lungs with and without severe alpha1-antitrypsin deficiency
por: Koczulla, A-Rembert, et al.
Publicado: (2012)

Safety and efficacy of alpha-1-antitrypsin augmentation therapy in the treatment of patients with alpha-1-antitrypsin deficiency
por: Petrache, Irina, et al.
Publicado: (2009)

Equine Mesenchymal Stem/Stromal Cells Freeze-Dried Secretome (Lyosecretome) for the Treatment of Musculoskeletal Diseases: Production Process Validation and Batch Release Test for Clinical Use
por: Mocchi, Michela, et al.
Publicado: (2021)

Structural characterization and conformational dynamics of alpha-1 antitrypsin pathogenic variants causing alpha-1-antitrypsin deficiency
por: Shaik, Noor Ahmad, et al.
Publicado: (2022)

Genetic and Serum Screening for Alpha-1-Antitrypsin Deficiency in Adult Patients with Cystic Fibrosis: A Single-Center Experience
por: Amati, Francesco, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_d3ldu4rmmo7bqv7k4q2mlquqai