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Interstitial Flow Recapitulates Gemcitabine Chemoresistance in A 3D Microfluidic Pancreatic Ductal Adenocarcinoma Model by Induction of Multidrug Resistance Proteins

Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most lethal cancers due to a high chemoresistance and poor vascularization, which results in an ineffective systemic therapy. PDAC is characterized by a high intratumoral pressure, which is not captured by current 2D and 3D in vitro models. Here,...

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Detalles Bibliográficos
Autores principales:	Kramer, Bart, de Haan, Luuk, Vermeer, Marjolein, Olivier, Thomas, Hankemeier, Thomas, Vulto, Paul, Joore, Jos, Lanz, Henriëtte L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770899/ https://www.ncbi.nlm.nih.gov/pubmed/31546820 http://dx.doi.org/10.3390/ijms20184647

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