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BACE1 Inhibition Using 2’-OMePS Steric Blocking Antisense Oligonucleotides
Amyloid beta-peptide is produced by the cleavage of amyloid precursor protein by two secretases, a β-secretase, beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) and a γ-secretase. It has been hypothesised that partial inhibition of BACE1 in individuals with a high risk of developing Alz...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770983/ https://www.ncbi.nlm.nih.gov/pubmed/31547430 http://dx.doi.org/10.3390/genes10090705 |